Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2008.540.546Agyei-FrempongM.T. FrempongN.Y.F. AboahK. BoatengK.A. 6200886This study sought to find the correlation between Free to TPSA (F/T PSA)
ratio and the histological grades of prostate cancer. Among 120 selected
from both in-patients and out-patient clinic of the urology unit, 51 underwent
tissue biopsies within six months of their PSA measurements using enzyme
immunoassay. The F/T PSA ratios of patients with prostate cancer were
compared to those with BPH, using the students` t-test. Correlation between
histology grades and F/T PSA ratios was calculated by the Pearson test
and linear regression. Receiver Operating Characteristic (ROC) curves
were generated from sensitivities and specificities of various F/T PSA
ratios, FPSA and TPSA levels. The F/T PSA ratio was significantly lower
in the group of patients with prostate cancer (PCa) (0.118 ± 0.0043)
compared to BPH (0.302 ± 0.0179, p<0.0001). There was also an
inverse correlation between F/T PSA ratios and aggressiveness of histology
grades (r^{2} = 0.76, p<0.0001), that is, the higher the histology
grade, the lower the F/T PSA ratio. The best accuracy was obtained with
F/T PSA ratio cut-off at 0.15, with specificity of 87.50% and sensitivity
of 100%. The use of the F/T PSA ratio improves PSA-based differential
diagnoses of prostate cancer in patients and can also lead to more specific
identification of potentially curable prostate cancer and reduce unnecessary
prostate biopsies.]]>Arthur, F.K.N., F.A. Yeboah, M. Adu-Frimpong, E.E. Sedudzi and K.A. Boateng,2006Badoe, E.A., E.Q. Archampong and J.T. da Rocha-Afodu, 2000Benson, M.C., I.S. Whang, A. Pantuck, K. Ring and S.A. Kaplan et al.,1992Bjork, T., A. Bjartell, P.A. Abrahamson, S. Hulkko and A. di Sant'Agnese et al.,1994Bostwick, D.G., W.H. Cooner, L. Denis, G.W. Jones and P.T. Scardino et al.,1990Catalona, W.J., D.S. Smith, R.L. Wolfert, T.J. Wang and H.G. Rittenhouse et al.,1995Christensson, A., T. Bjork, O. Nilsson, U. Dahlen and M.T. Matikainen et al., 1993Christensson, A., C.B. Laurell and H. Lilja,1990Filella, X., J. Alcover, R. Molina, A. Rodriguez and P. Carretero et al.,1997Leers, M.P.G., M. Nap, R. Herwig, K. Delaere and F. Nauwelaers,2008Li, W., Y. Ren, V. Mee and P.Y. Wong,1999Lilja, H., A. Christensson, U. Dahlen, M.T. Matikainen and O. Nilsson et al.,1991Malarkey, M.L. and M.E. McMorrow,2000Mcneill, S.A. and T.B. Hargreave,2000Nelson, W.G., A.M. DeMarzo and W.B. Isaacs,2003Oesterling, J.E.,1991Stamey, T.A., N. Yang, A.R. Hay, J.E. McNeal and F.S. Freiha et al.,1987Steinberg, D.M., J. Sauvageot, S. Piantadosi and J.I. Epstein,1997Toubert, M.E., J. Guillet, M. Chiron, P. Meria and C. Role et al.,1996Van Iersel, M.P., W.P.J. Witjes, C.M.G. Thomas, M.F.G. Segers and G.O.N. Oosterhof et al., 1996Stenman, U.H., J. Leinonen, H. Alfthan, S. Rannikko and K. Tuhkanen et al.,1991