Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2008.469.476F. IbrahimFakhry M. DrazHossam H. Al SherbeniHend 5200885The study aimed to assess serum levels of vascular endothelial growth
factor (VEGF) in patients with systemic lupus erythematosus (SLE) and
to elucidate its correlation with clinical features, laboratory parameters
and the disease activity in addition to the effect of SLE activity on
hemoglobin dielectric properties. We studied 30 female patients with SLE
and 10 healthy female controls. Disease activity was evaluated by SLE
disease activity index (SLEDAI) score. Laboratory investigations included
complete blood count, erythrocyte sedimentation rate (ESR), urine analysis,
24 h total urinary protein, serum creatinine, ANA, anti-DNA, complement
component C3, lupus anticoagulant and VEGF as well as dielectric
relative permittivity (ε′) and conductivity (σ) of hemoglobin
(Hb) were examined in the range of frequency from 20 to 100 kHz. Serum
levels of VEGF were significantly increased in SLE patients (501±120.5
pg mL-1) when compared with controls (65±22.3 pg mL-1)
(p<0.001). VEGF serum levels were significantly increased in patients
having renal involvement than those without (p<0.001). SLEDAI score
was positively correlated to VEGF serum level (r = 0.81, p<0.0001).
The dielectric results indicated that the studied hemoglobin (Hb) has
a dielectric dispersion in the frequency range used. The increase in the
electrical conductivity and relaxation time for SLE patients (non-renal)
and SLE patients (renal) indicates pronounced changes in the molecular
structure of Hb of these patients. The data support the conclusion that
VEGF may be relevant to SLE pathogenesis. Its concentration seems to be
a marker of SLE activity. SLE may alter dielectric properties of Hb and
that probably affected cell to cell communication. VEGF in combination
with dielectric dispersion of Hb could help in SLE monitoring and planning
of treatment.]]>Avihingsanon, Y., P. Phumesin, T. Benjachat, S. Akkasilpa, V. Kittikowit, K. Praditpornsilpa, J. Wongpiyabavorn, S. Eiam-Ong, T. Hemachudha, K. Tungsanga and N. Hirankarn,200669747753Blau, H.M. and A. Banfi,20017532534Bombardier, C., D. Gladman, B. Urowitz, D. Caron and C.H. Chang,199235630640Bowers, L.D.,198026551554Brown, L.F., B. Berse, K. Tognazzi, E.J. Manseau, L. Van de Water, D.R. Senger, H.F. Dvorak and S. Rosen,19924214571461Campbell, N.A.,19964th Edn.pp: 140-158.pp: 140-158.Cole, K.S. and R H. Cole,19419303341Clancy, R., G. Marder, V. Martin, H.M. Belmont, S.B. Abramson and J. Buyon,20014412031208Dvorak, H.F., M. Detmar, K.P. Claffey, J.A. Nagy, L. Van de Water and D.R. Senger,1995107233235Ferrara, N.,199977527543Folkman, J.,199512730Foster, K. and H. Schwan,19951995pp: 25-102pp: 25-102Fuhrmann-Benzakein, E., M.N. Ma, L. Rubbia-Brandt, G. Mentha, D. Ruefenacht, A.P. Sappino and M.S. Pepper,2000854045Gabriel, C., S. Gabriel and E. Corthout,19964122312249Ghannam, M., R. El-Gebaly, M. Gabern and A. Fadel,2002in vivo studies).]]>21255268Grant, E.H.,19831st Edn.,Honkanen, E.O., A.M. Teppo and C. Gronhagen-Riska,20005723432349Houck, K.A., N. Ferrara, J. Winer, G. Cachianes, B. Li and D.W. Leung,1991518061814Ibrahim, F.F., M.M. Ghannam and F.M. Ali,200224779790Ibrahim, F.F., M.M. Sayed, H.A. El-garem and M.M. Ghannam,200876672Iruel-Arispe, L., K. Gordon, C. Hugo, A.M. Duijvestijn, K.P. Claffey, M. Reilly, W.G. Couser, C.E. Alpers and R.J. Johnson,199514717151727Johnson, A.M.,19931172931Josko, J., B. Gwozdz, H. Jedrzejewska-Szypulka and S. Hendryk,2000610471052Kadono, T., K. Kikuchi, M. Kubo, M. Fujimoto and K. Tamaki,199635392397Kikuchi, K., M. Kubo, T. Kadono, N. Yazawa, H. Ihn and K. Tamaki,199813910491451Lahita, R.G.,20044th Edn.,Matsumoto, T. and L. Claesson-Welsh,20012001re21re21McAlindon, T.,200012104112Navarro, C., L. Candia-Zuniga, L.H. Silveira, V. Ruiz, M. Gaxiola, M.C. Avila and M.C. Amigo,2002112124Noguchi, K., N. Yoshikawa, S. Ito-Kariya, Y. Inoue, Y. Hayashi, H. Ito, H. Nakamura and K. Iisjima,1998918151825Ostendorf, T., U. Kunter, F. Eitner, A. Loos and H. Regele et al.,1999165 mediates glomerular endothelial repair.]]>104913923Paleolog, E.M.,199635917919Plate, K.H. and P.C. Warnke,199735365372Polk, C.,199228279289Polk, C. and E. Postow,19962nd Edn.,pp: 25-102pp: 25-102Risau, W.,1997386671674Robak, E., A. Wozniacka, A. Sysa-Jedrzejewska, H. Stepien and T. Robak,200211348355Robak, E., A. Sysa-Jedrzejewska and T. Robak,200312293298Schiffenbauer, J., B. Hahn, M.H. Weisman and L.S. Simon,20045024152422Sezer, O., C. Jakob, J. Eucker, K. Niemoller, F. Gatz, K. Wernecke and K. Possinger,2001668388Shulman, K., S. Rosen, K. Tognazzi, E.J. Manseau and L.F. Brown,19967661666Tan, E.M., A.S. Cohen and J.F. Fries,19822512711277Thomas, K.A.,1996271603606Trivelli, L.A., H.M. Ranney and H.T. Lai,1971284353357Yancopoulos, G.D., S. Davis, N.W. Gale, J.S. Rudge, S.J. Wiegand and J. Holash,2000407242248