Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2008.239.243GhazaviA. MosayebiG. MashhadiE. Shariat-ZadehM.A. RafieiM. 3200883This study was planned to determine the levels of uric
acid (UA) and CRP at preeclampsia and their association with the severity
of the disease. In a cross-sectional, case-control study we measured UA
and CRP levels in blood samples from 46 women with preeclampsia, 23 normal
pregnant women and 23 non pregnant women matched for age, BMI, parity
and gestational age were measured. Twenty three patients had developed
severe and 23 mild preeclampsia. UA and CRP were measured by enzymatic
method and enzyme-linked immunosorbent assay, respectively. Roc curve
was used to determine the optimal cutoff value. Results showed CRP and
UA concentrations were higher in Preeclamptic group (33.77 ±25.97,
5.93 ±0.75) compared with normal pregnant group (17.31 ±19.54,
5.47 ±0.41). CRP levels were also significantly elevated in women
with severe preeclampsia compared to those mild preeclampsia (42.26 ±24.04,
16.81 ±22.03). Determination of serum CRP levels may be used as
marker for the severity of preeclampsia. We also suggest that serum UA
level of 5.5 mg dL-1 is best cutoff point for the diagnosis
of preeclampsia.]]>Acien, P., G. Lloret and M. Lloret,199032229235American College of Obstetricians and Gynecologists,199621918Belo, L., A. Santos-Silva and M. Caslake,200322129141Boneu, B., A.S.P. Fournie, H. Grandjean, R. Bierme and J. Pontonnier,1980118594Dekker, G.A. and B.M. Sibai,1991165160172Du Clos, T.W.,199623253260Fay, R.A.,199030141142Frenkel, Y., G. Barkai, S. Mashiach, E. Dolev, R. Zimlichman and M. Weiss,199177689691Funai, E.F., Y. Friedlander, O. Paltiel, E. Tiram, X. Xue, L. Deutsch and S. Harlap,200516206215Jeyabalan, A. and K.P. Conrad,2007124252437Hill, L.M.,197853743751Kharb, S., N. Gulati, V. Singh and G.P. Singh,199846238240Kumar, A., B.K. Ghosh and N.S. Murthy,2005595763Lancet, M. and I.L. Fisher,195663116119Myatt, L. and M. Miodovnik,1999234557Okerengwo, A.A., A.I. Williams and P.A. Ibeziako,199033121125Ray, J., K. Vasishta, S. Kaur, S. Majumdar and H. Sawhney,199966245250Redman, C.W., L.G. Beilin, J. Bonnar and R.H. Wilkinson,1976113701373Redman, C.W.,198732151160Redman, C.W., G.P. Sacks and I.L. Sargent,1999180499506Sanchez-Ramos, L., S. Sandroni, F.J. Andres and A.M. Kaunitz,199177510513Teran, E., C. Escudero, W. Moya, M. Flores, P. Vallance and P. Lopez-Jaramillo,200175243249Tjoa, M.L, J.M.G. Van Vugt, A.T.J.J. GO, M.A. Blankenstein, C.B.M. Oudejans and I.J. Van Wijk,2003592937Ustun, Y., Y. Engin-Ustun and M. Kamaci,2005121154158Vickers, M., I. Ford and R. Morrison,20039011921197Yoshimura, A., T. Ideura, S. Iwasakis and S. Koshikawa,199016216391640