Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2008.216.221VasudevanR. IsmailPatimah StanslasJohnson ShamsudinNorashikin 3200883The objective of this study is to determine the association
between the C-511T polymorphism of Interleukin -1 β gene in T2DM
with or without hypertension in Malaysian population. A total of 175 subjects
were recruited for this study. Genotyping of C-511T variant was performed
by Hot-start PCR-RFLP analysis. The frequency for CC, TC and TT genotypes
of C-511T variant in IL-1 β gene was 25.45, 40 and 34.55% in T2DM,
25, 51.67 and 23.33% in T2DM with hypertension and 21.66, 36.67 and 41.67%
respectively found in controls (p>0.05). This study suggests that there
was no significant difference in the genotypic distribution of C-511T
polymorphism of IL-1 β gene between T2DM and controls. Therefore,
C-511T variant in IL-1 β gene polymorphism is not considered an independent
risk factor or not a predictor for T2DM in Malaysian population.]]>Achyut, B.R., A. Srivastava, S. Bhattacharya and B. Mittal,2007377163169American Diabetes Association,2002257477Anuradha, S., V. Radha, R. Deepa, T. Hansen, B. Carstensen and O. Pedersen20052824302435Bidwell, J., L. Keen, G. Gallacher, R. Kimberly and T. Huizinga et al.,19991319Chou, H.T., C.H. Tsai, W.C. Chen and F.J. Tsai,200546397406Diabetes, National Health and Morbidity Survey, 19961996Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Hollegaard, M.V. and J.L. Bidwell,20067269276Ismail, I.S., W. Nazaimoon, W. Muhamad, R. Letchuman, M. Singaraveloo, F.L. Hew, C. Shuguna and B.A.K. Khalid,200118501508Joachim, S., K. Anja and M. Matthias,200352812817Kristiansen, O.P., F. Pociot, J. Johannesen, R. Bergholdt, C.A. Dinarello, L. Nerup and T. Mandrup-Poulsen,200012171175Laakso, M., S. Lehto, I. Penttila and K. Pyorala,19938814211430Loughrey, B.V., A.P. Maxwell, D.G. Fogarty, D. Middleton and J.C. Harron et al.,199810984988Mandrup-Poulsen, T., U. Zumsteg, J. Reimers, F. Pociot and L. Morch et al.,19935185191McCarthy, M.I.,2004133341Mohamad, M., F. Arshad, M.I. Mohd Noor and R. Ali,19976203206Shafie, O., I. Fatanah and D. Noor Azah,20043612Persu, A.,200624443445Samanta, A., A.C. Burden and B. Fent,19877416Tuttle, H.A., G. Davis-Gorman, S. Goldman, J.G. Copelandm and P.F. McDonagh,200418343351Turner, R.C., H. Millns, H.A. Neil, I.M. Stratton, S.E. Manley, D.R. Matthews and R.R. Holman,1998316823828Vohnout, B., A. Di Castelnuovo, R. Trotta, A. D'Orazi, G. Panniteri, A.Montali, M.B. Donati, M, Arca, L. Iacoviello,2003885460