Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2007.31.41El-SayedHamda Hussein Amin HusseinNadia Yousef GhanemLobna Megeed LotfyAbeya Abdel Raouf RaafatManar Abdel 1200771The prevalence of cryoglobulinemia (CG) in Hepatitis C Virus (HCV) infection with and without superimposed renal failure is an acknowledged finding. This study chose to investigate some immunological and hematological features dictated by CG and End-stage Renal Disease (ESRD) onto the disease course and progression in a total of 47 HCV cases classified into a hemodialysis (HD, 25 cases) and non-HD (NHD, 22 cases) groups. Further subgrouping according to presence or absence of cryoglobulins (Cgs) was done. The battery of investigations included platelet count, estimation of prothrombin INR, HCV RNA, Cgs, Autoantibodies Namely Antinuclear (ANA), anti-smooth muscle (ASMA) and antimitochondrial (AMA), markers of complement (c) activation (C3, C4, C3d), immunoglobulins (Ig) G and M, in addition to flow cytometry for B-cell separation and detection of CD81 and CD5 positive cells. We came to the conclusion that HCV patients on HD had lower viremia levels and more impaired immune status than those with normal renal function. CG when present manipulated the immune system further and was correlated to most of the immunological (RF, autoantibodies, C4, C3d and IgM) and hematological (platelets and INR) markers. Overexpression of CD81 and CD5 was observed particulary in Cg positive cases, thus necessitating follow-up for fear of potential lymphotransformation.]]>Agarwal, N., R. Handa, S.K. Acharya, J.P. Wali, A.K. Dinda and P. Aggarwal,2001113170174Almirall, J., M.J. Amengua, T. Lopez, X. Andreu and J. Oristrell et al.,200222531539Alvarez, F., P.A. Berg, F.B. Bianchi, L. Bianch and A.K. Burroughs et al.,199931229938Balabanova, R.M., E.V. Shekshina and L.V. Kozlov,2004767477Balwani, F., Y. Zaidi and G.N. Kakepoto,20045420022006Cacoub, P., F.L. Fabiani, L. Musset, M. Perrin and L. Frangeul et al.,199496124132Cacoub, P., C. Renou, E. Rosenthal, P. Cohen and I. Loury et al.,200074756Cicardi, M., D. Cesana, E. Del-Ninno E. Pappalardo, E. Silin, A. Agostoni and M. Colombo,20007138143Curry, M.P., L. Golden-Mason and N. Nolan,20015+ B cells is associated with mild disease in chronic HCV infection.]]>32121125Dammacco, F. and D. Sansonno,199287352356Dammacco, F., D. Sansonno, C. Piccoli, V. Racanelli, F.P. D'Amore and G. Lauletta,200020143157Dimitrakopoulos, A.N., T. Kordossis, A. Hatzakis and H.M. Moutsopoulos,1999130226230Dominguez, J.H. and E. Sha,200266976Fabris, P., G. Tositti, M.T. Giordani L. Romano and C. Betterle et al.,200369339343Ferri, C., F. Caracciolo, A.L. Zignego, L. La-Civita and M. Monti et al.,199488392394Ferri, C., A.L. Zignego and S.A. Piler,20025413Fozzato, G., C. Mazzaro, M. Crovatto, M.L. Modolo and S. Ceselli et al.,19948430473053Franzin, F., D.G. Efremov and G. Pozzato,199590548552Gaafar, M., S. Lashin and M. Negm,200416655668Gad, A., Tanaka-Eijt, A. Matsumoto, A. El-Hamid and K. Serwah et al.,200370594599Hausfater, P., P. Cacoub, E. Rosenthal, N. Bernard and V. Loustaud-Ratti et al.,200064107111Idilman, R., A. Colantoni, N. De-Maria, S. Alkan, S. Nand and D.H. Van-Thiel,200411302309Kayali, Z., V.E. Buckwold, B. Zimmerman and W.N. Schmidt,200236978985Kwok, S. and R. Higuchi,1989339237238Liakina, V., A. Speiciene and J. Naraskevicene,20028CR31CR36Lunel, F., I. Musset, P. Cacoub, L. Frangeul and P. Cresta et al.,199410612911300McCarty, G.A., D.W. Valencia and M.J. Fritzler,1984McMurray, R.W.,199824353374Misiani, R., P. Bellavita and D. Fenili,1992117573577Nishiyama, Y., A. Schimatsu, M. Arakawa, M. Nagao and A. Saito et al.,20014911391145O'Garra, A., R. Chang and N. Go,199222711717Okuda, K., O. Yokosuka and Y. Otake,199813248252Okudo, M., H. Hayashi, K. Yokozeki and Y. Irie,1996347909910Peano, G., G. Menardi, A. Ponzetto and L.M. Fenoglio,199415427332736Pereira, B.V.G. and A.S. Levey,199751981999Pesanti, E.L.,200115813832Pers, J.O., C. Jamin, F. Prendine-Hug, P. Lydyard and P. Youinou,19993239245Persico, M., F.A. De-Marino, D.I. giacomo, G. Russo and E. Persico et al.,200398884888Pertosa, G., G. Grandaliano, L. Gesualdo and F.P. Schen,200076S104S111Pietrogrande, M., M. Corona, S. Milani, A. Rosti, M. Ramella and G. Tordato,199513S109S113Pileri, P., Y. Uematsu, S. Campognol, G. Galli and F. Falugi et al.,1998282938941Ramos, C.M., L.J. Jara, F. Medina, J. Rosas and J. Calvo-Alen et al.,2005257549557Rehermann, B.,200020127141Rieu, V., P. Cohen, M.H. Andre, L. Mouthon and P. Godmer et al.,200241290300Shirin, H., Y. Awni, P. Petchenko, Z. Krepel, R. Bruck and D. Meytes,200242427Sasso, E.H.,2000153040Schmidt, W.N., J.T. Stapleton, D.R. LaBrecque, F.A. Mitros and P.A. Kirby et al.,200031737744Schott, P., H. Hartmen and G. Ramadori,20011612751285Siagris, D., C. Labropoulou-Karatza, M. Christofidin G. Dimitrios and T. Konstantinos et al.,200315133137Silverman, L.M., R.H. Christenson and G.H Grant,19861986pp: 572-573pp: 572-573Simarro, M., C. Pelassy, J. Calvo, L. Places, C. Aussel and F. Lozano,199715943074315Tanako, K., T. Aiyama, J. Imai, Y. Morishita, T. Fukatsu and S. Kakumu,19959018471852Tillman, H.L. and A. Schwartz,20034410981106Tornita, N., F. Kodama, M. Takabayashi, T. Kawano and S. Yamaji et al.,20034411591164Toubi, E., A. Kessel, L. Goldstein, G. Slobodin, E. Sabo, Z. Shmuel and E. Zuckerman,200134774780Valentini, G., A. Mantelli, M. Persico, C. Tuccillo and G. Del-Vecchio-Blanco et al.,1999177579Weiner, S.M., T. Berg, H. Berthold, S. Weber and T. Peters et al.,199829375385Weng, W. and S. Levy,20034411131120Wu, M.J., K.H. Shu, C.H. Cheng, C.H. Chen and J.D. Lian,2000355257Zabek, J., J. Kosowska and J. Cianciara,200155459464Zahran, N.M., A.M. Amer and M.A. El-Mansy,200126945962Zehender, G., C. De Maddatena, G. Monti, M. Ballare and F. Saccardo et al.,1995135S87S90Zignego, A.L., C. Ferri, C. Giannini, M. Monti and L. La-Civita et al.,19961243134Zuckerman, E. and T. Zuckerman,200215119125Zuckerman, E., G. Slobodin, A. Kessel, E. Sabo, D. Yeshurun, K. Halas and E. Toubi,2002128353358