Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2006.838.842Plasmodium berghei berghei Infection in Mice]]>OreagbaA.I. AshorobiR.B. 5200665The present study was conducted to evaluate the antiplasmodial activity of retinol on chloroquine-sensitive Plasmodium berghei berghei infection in mice. Albino mice weighing 18-25 g where treated with retinol (50-200 mg kg-1) in a set of experiments to investigate chemotherapeutic and prophylactic effect against Plasmodium bergheiberghei infection in mice. Treatment in one of the chemotherapeutic groups continued throughout the study period. Retinol demonstrated a mild dose dependent schizontocidal effect on early and established infection. This effect became stronger on chronic administration but it also produced toxic manifestations and eventual death in most of the animals. Retinol also demonstrated a prophylactic effect by significantly delaying the onset of infection. The repository activity of retinol was however lower than that of the standard drug (Pyrimethamine-1.2 mg kg/day). Retinol possesses antiplasmodial activity especially during chronic administration thus suggesting that it might have a role in malaria control. Further studies in the area of its structural activity relationships are needed to justify this assertion.]]>Bendich, A. and L. Langseth, 198949358371Binka, F.N., D.A. Ross, S.S. Morris, B.R. Kirkwood and P. Arthur et al.,199561853859Collins, M.D., C.I. Eckhoff, G. Bochert and H. Nau,199266652659Dal-Pizzol, F., F. Klamt, M.S. Benfato, E.A. Bernard and J.C. Moreira,2001344395404Das, B.S., D.I. Thurnham and D.B. Das,19966494100Davis, T.M.E., T.S. Skinner-Adams and J. Beilby,1998In vitro growth inhibition of Plasmodium falciparum by retinol at concentrations present in normal human serum.]]>69111119Filteau, S.M., S.S. Morris and R.A. Abbott,199358192197Galan, P., C. Samba, R. Luzeau and O. Amedee-Manesme,199060224228Hamzah, J., T.S. Skinner-Adams and T.M.E. Davis,2003In vitro antimalarial activity of retinoids and the influence of selective retinoic acid receptor antagonists. ]]>87345353Hamzah, J., T.M.E. Davis, T.S. Skinner-Adams and J. Beilbyb,2004Plasmodium falciparum in vitro.]]>107136144Knight, D.J. and W. Peters,198074393404Krishnan, S., A.D. Krishnan, A.S. Mustafa, G.P. Talwar and V. Ramalingaswami,1976Plasmodium berghei.]]>106784791Levander, O.A. and A.L. Ager,1993107S95S106Mangelsdorf, D.J., E.S. Ong, J.A. Dyck and R.M. Evans,1990345224229McGilvray, I.D., L. Serghides, A. Kapus, O.D. Rotstein and K.C. Kain,2000Plasmodium falciparum-parasitized erythrocytes: A role for CD36 in malarial clearance.]]>9632313240Muller, S., E. Liebau, R.D. Walter and R.L. Krauth-Siegel,200319320328Murata, M. and S. Kawanishi,200027520032008Peters, W.,1965Plasmodium berghei Vincke and Lips, 1948. I. Chloroquine resistance.]]>178089Ryley, J.F. and W. Peters,197084209222Samba, D.C., L.K. Basco, F. Bleiberg-Daniel, D. Lemmonier and J. Le Bras,1992in vitro development of Plasmodium falciparum.]]>6299100Schwartz, J.L.,199612612211227Schwarz, K.B., J.M. Cox, S. Sharma, L. Clement and J. Humphrey et al.,199725408414Serghides, L. and K.C. Kain,2002Falciparum malaria.]]>35914041406Shankar, A.H., B. Genton, R.D. Semba, M.Baisor, J. Paino and S. Tarnja,1999P. falciparum in young children in Papua Guinea: A randomised trial.]]>354203209Sibmooh, N.B., I.P. Pipitaporn, J. Wilairutl, R. Dangdoungjai, R.U. Looareesuiwan and L.T. Antharaksri,20002312751280Skinner-Adams, T., H. Barret and T.M.E. Davies,1999in vitro of vitamin A (retinol) in combination with novel and established antimalarial drugs.]]>93550551Sommer, A., J. Kartz and K.P. West,19961st Edn.pp: 19-250pp: 19-250Stoltzfns, R.R., F. Julal, P.N. Haevy and M.C. Nesheim,198911920302037Wiegand, U.W., S. Hartmann and H. Hummler,199868411416Semba, R.D. and M.W. Bloem,2001