Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2006.225.228Sharifi-MoodBatool MoghaddamSmail Sanei-SalehiMasoud EshghiPayman KhosraviSoheila KhaliliManijeh 2200662The aim of this study was to determine the seroprevalence of hepatitis C, hepatitis B and HIV infections in hemophilics. Seventy four hemophilic patients (62 male, 12 female, mean age 13 years, range 3-19 years) of registered hemophilics, from March 1986 to Oct 2005, in Zahedan, a city in Sistan and Baluchestan province (Southeast of Iran), were enrolled in this study and evaluated for hepatitis C virus. (HCV-Ab) hepatitis B surface antigen (HBsAg) and HIV-Ab. Serological tests for HIV, HBsAg and HCV were done by ELISA(Sorin Bio medika Kit). Positive samples for HCV were also confirmed by western blot. Out of 62 men with hemophilia, 23 cases (37%) were positive for HCV-Ab. All women with hemophilia were antibody negative. There was a significant difference between sex and seropositivity for HCV-Ab (p = 0.007). Among hemophilics, 35 cases were from persian race and 39 cases were from Baluch race. HCV-Ab was positive in seventeen cases of Persian race and six cases from Baluch race. There was, also significant difference between race and seropositivity (p = 0.003). Seropositivity for HCV-Ab correlated with the time of treatment (before or after 1996s) with clotting factors (p = 0.05). Among 74 cases with hemophilia, 3 cases (2 male and one female) were HBsAg positive (4%) and there was no significant difference between sex and having a positive HBsAg (p = 0.8). Out of 35 persian patients, 2 cases were HBsAg positive. Only one case from Baluch patients had a positive test for HbsAg. there was no significant difference between positive test for HBsAg and race (p = 0.2). Also, there was no correlation between the time of treatment (before or after the 1996s) and positive test for HbsAg (p = 0.47). Anybody of our patients had a positive test for HIV-Ab. Upon the results emerged from this study, we recommend that all hemophilics should be evaluated for HCV and HBV infections but evaluation for HIV infection is not necessary.]]>Alter, H.J., R.H. Purcell, J.W. Shih, J.C. Melpolder, M. Houghton, Q.L. Choo and G. Kuo,198932114941500CDC.,199241228231CDC.,199443347, 353356Alter, M.J.,199515514CDC.,199726597599Bray, G.L., E.D. Gomperts, S. Courter, R. Gruppo and E.M. Gordon et al.,19948324282835Goedert, J.J., M.E. Eyster, M.M. Ledreman, T. Mandalaki and P. De Moerloose et al.,2002515841589Kasper, C.K. and J.M. Lusher,199333422434Kazimierska, E. and J. Gorski,19892189194Lawrence, J.R.,199468S21S24Lobato, M.N., M.J. Oxtoby, L. Augustyniak, M.B. Caldwell, S.D. Wiley and R.J. Simonds,199617721725Makris, M., F.E. Preston, D.R. Triger, J.C. Underwood, Q.L. Choo, G. Kuo and M. Houghton,199033511171119Matania, T., M.S. Triemstra, R. Frits and M.D. Rosendaal C. Smit, H.M. Van der Ploeg and E. Briet,199511823827Mauser-Bunschoten, E.P., D. Bresters, A.A. Drimmelen, G. Roosendaal, H.T.M. Cuypers et al.,199545241246Rosenberg, P.S. and J.J. Goedert,199817155168Smith, P.S. and P.H. Levine,198474616617Troisi, C.L., F.B. Hollinger, W.K. Hoots, C. Contant and J. Gill et al.,199381412418CDC.,1996452929