Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2005.181.185RezaeeAbbas AnsariMajid ShahporiReza 3200553The efficacy of co-trimazine was studied in vitro in mouse macrophages infected with Brucella abortus. The macrophages first were allowed to phagocytes the Brucella abortus. After uptake period, extra cellular bacteria were removed by gentamicin. The bacteria were able to grow in the cells with an apparent multiplication rate of about 90min. Bactericidal activity was measured after treatment of the macrophages with co-trimazine. Co-trimazine showed a bactericidal effect at MIC concentration used, (6.32 mg L-1 trimethoprim and 8.19 mg L-1 sulphadiazine) and a total killing of intracellular bacteria at concentrations of 9.33 mg L-1 trimethoprim and 12.46 mg L-1 sulphadiazine). Results of the study show that co-trimazine was effective on intracellular Brucella abortus.]]>Tabrizi, S.N. and R.M. Robins-Browne,1993158201206Al-Nasser, A., A. Al-Aska, S. Al-Balla, I.A. Al-Mofleh, M. Al-Sekait and O.S. Hassan,199911245245Phillipon, M., M.G. Plommet, A. Kazmierczak and J.L. Marly,1999136481488Pong, A.J. and S. Bradley,200113711737Wormser, G.P., G.T. Keusch, R.C. Heel,198224459518Rezaee A. and Q. Behzadiannejad,2002Listeria monocytogenes in cyclosporin a treated mice.]]>2209212Richards, R.M.E., J.Z. Xing and D.W. Gregory,199536607618Vladoianu, I.R., H.R. Chang and J.C. Pechere,1990Salmonella typhi and Salmonella typhimurium: Bacteria survival within macrophages of murine and human origin.]]>828390Shasha, B., R. Lang and E. Rubinstein,199433545551Lang, R., B. Shasha and E. Rubinstein,19933723332336Ural, O.,20016511Martin, I., E.G. Sanchez and L. Martinez,1999In vitro activities of six new fluoroquinolones against Brucella melitensis.]]>43194195Rodriguez, J.A.G., J.L.B. Munoz, M.J. Fresnadillo and I. Trujillano,1993In vitro activities of new macrolides and rifapentine against Brucella sp.]]>37911913Brogen, R.N. and D.H. Peters,199448599616Mayer, L. and P. Keen,1989Staphylococcus aureus.]]>24709718Prokesch, R.C. and W.L. Hand,198221373380Young, E.J.,20002000pp: 2921-2926pp: 2921-2926