Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2004.246.251MackayGillian M. M. ForrestCaroline GouldStuart R. W. StoneTrevor 4200444Kynurenines are tryptophan metabolites which include an agonist (quinolinic acid) and an antagonist (kynurenic acid) at glutamate receptors on intrinsic myenteric neurons. We have reported raised kynurenine and kynurenic acid in patients with inflammatory bowel disease, raising the possibility of using drugs to modulate the pathway. We have now measure etc. Despite a significant difference in the colitis activity index between active and remission phases, there were no significant differences in the levels of neopterin, kynurenines or lipid peroxidation products. Thus, a change in immune status may not be involved in the transition from active disease to remission, nutritional or endocrine factors may be important. The kynurenine pathway does not appear to be an appropriate target for drug development in this condition.]]>Altindag, Z.Z., G. Sahin, F. Inanici and Z. Hascelik,199818107111Fuchs, D., G. Weiss G. Reibnegger and H. Wachter,199229307341Kullich, W.,199312387391Satoh, T., L. Morris-Brown, W.A. Blattner, E.M. Maloneyb and C.C. Kurman et al.,199888176182Espey, M.G., O.N. Chernyshev, J.F. Reinhard, M.A.A. Namboodiri and A.C. Colton,19978431434Heyes, M.P., K. Saito and S.P. Markey,1992283633635Liu, M.T., J.D. Rothstein, M.D. Gershon and A.L. Kirchgessner,19971747644784Sinsky, M. and J. Donnerer,1998258109112Moroni, F., S. Luzzi, S. Franchi-Micheli and L. Ziletti,1986685762Shannon, H.E. and B.D. Sawyer,1989251518523Luzzi, S., S. Zilletti, S. Franchi-Micheli, A.M. Gori and F. Moroni,19989512711277Moroni, F., D.E. Pellegrini-Giampietro and M. Alesiani,1989163123126Perkins, M.N. and T.W. Stone,1982247184187Stone, T.W.,199345309379Stone, T.W. and L.G. Darlington,20021609620Forrest, C.M., P. Youd, A. Kennedy, S.R. Gouldb, L.G. Darlingtonb and T.W. Stone,20029436442Walmsley, R.S., R.C. Ayres, R.E. Pounder and R.N. Allan,1998432932Anonymous,199346198200Westergren, A.,192154247282Stone, T.W., G.M. Mackay, C.M. Forrest, C.M. Forrest, C.J. Clark and L. Gail Darlington,200341852859Herve, C., P. Beyne, H. Jamault and E. Delacoux,1996675157161Shibata, K.,1988430376380Niederweiser, D., D. Fuchs, A. Hausen, G. Judmaier, G. Reibnegger, H. Wachter and C. Huber,1985170320326Granditsch, G., D. Fuchs and A. Hausen,199022327Judmaier, G., P. Meyersbach, G. Weiss, H. Wachter and G. Reibnegger,199388706711Konecny, M., J. Ehrmann and J. Bartek,19961404748Duclos, B., J.M. Reimund, J.M. Lang, G. Coumaros and P. Chamouard et al.,1990142227Prior, C., R. Bollbach and D. Fuchs,19861551121Nielsen, O.H., B. Vainer, S.M. Madsen, J.B. Seidelin and N.H. Heegaard,200095359367Koch, T.R., L.X. Yuan, S.J. Stryker, P. Ratliff, G.L. Telford and E.C. Opara,20004518141819Stone, T.W.,200164185218Stone, T.W. and M.N. Perkins,198172411412Reis, H.J., A.R. Massensini, M.A.M. Prado, R.S. Gomezt, M.V. Gomez and M.A. Romano-Silv2000101237242Ren, J., H.Z. Hu, S. Liu and J.D. Wood,19991030453048