Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2004.170.175HafforAl-Said 2200442Obstructive sleep apnea (OSA) relates to cardiovascular diseases. This study
evaluated oxygenation and the ventilatory responses to hypercapnea in OSA in
whom cardiac output is elevated. Sleep studies were conducted using CASE system.
From an arterial line, blood pressure was monitored directly by blood pressure
transducer and blood samples were drawn from the same arterial line for arterial
blood gases (ABG) analysis. Cardiac output was calculated by the indirect Ficks`
method. Gas exchange measures were determined using automatic Douglas Bag System
in which expired gases were analyzed online using mass spectrometer (Perkin
Elmer-1100). Ventilation was recorded continuously by mass flow meter (TSI).
Results of sleep studies indicated that the average obstructive
apnea index was 74%. During wake state, the average cardiac output
was 9.86 LPM, alveolo-arterial PO2 differences (A-a PO2)
was 18.82 Torr and normalized VE was 3X for each level of CO2. At
maximum respiratory response PaCO2 was elevated reflecting increased
capacity for CO2 stores leading to increased CO2 load
on the lungs. Present data indicated that significant obstructive sleep apnea
occurs in adult in whom cardiac output, heart rate and blood pressure were elevated
during day time. Based on the results of the present study it can be concluded
that OSA is considered a risk factor for heart diseases.]]>Dempsey, J.A.,19979912Haffor, A.S.A. and J.G. Nail,198821101109Chen, L., A.L. Sica and S.M. Scharf,19948612361246Fung, J.W., T. Li, D.K. Choy, G. Yip, F.S. Ko, J.E. Sanderson and D.S.C. Hui,200221422429Kales, A., R.J. Cadieux, L.C. Shaw, A. Vela-Bueno and E.O. Bixler et al.,198432410051008Koskenvuo, M., J. Kaprio, T. Telakivi, M. Partinen, K. Heikkila and S. Sarna,19872941619Fletcher, E.C.,199598118128Phillipson, E.,199332812711273Hla, K.M., T.B. Young, T. Bidwell, M. Palta, J.B. Skatrud and J. Dempsey,1994120382388Fogel, R.B., A. Malhotra, G. Pillar, S.D. Pittman, A. Dunaif and D.P. White,20018611751180Motta, H., C. Guilleminault, J.S. Schroeder and W.C. Dement,197889454458Haffor, A.S.A., R.L. Bartels, R.L. Hamlin, T.E. Kirby and A.L. Kunze,1987958190Fletcher, E.C., J. Lesske, W. Qian, C.C. Miller and T. Unger,199219555561Bender, P.R., B. Groves, R.E. McCullough, R.G. McCullough and S.Y. Hoang et al.,19986525922597Ringler, J., B.C. Basner, R. Shannon, R. Schwartzstein, H. Manning, S.E. Weinberger and J.W. Weis,19906921432148Brooks, D., R.L. Horner, L.F. Kozar, T.K. Waddell, C.L. Render and E.A. Phillipson,19968110121018O'Donnell, CP., A.R. Schwartz, P.L. Smith, J.L. Robotham, R.S itzgerald and M. Shirahata,199615417631770Phillipson, E.A., E. Murphy and L.F. Kozar,197640688693Robotham, J.L., J. Rabson, S. Permutt and B. Bromberger-Barnea,19794712951303Scharf, S.M., R. Brown, N. Saunders and L.H. Green,197947582590Tarasiuk, A. and S.M. Scharf,1993148323329Davenport, P.W., F.J. Thompson, R.L. Reep and A.N. Freed,1985328150153Issa, F.G., S.G. McNamara and C.E. Sullivan,19876218321836Gandevia, S.C. and G. Macefield,198977203214Gleeson, K., C.W. Zwillich and D.P. White,1990142295300Kimoff, R.J., H. Makino, R. Horner, L.F. Kozar, F. Lue, A.S. Slutsky and E.A. Phillipson,19947618101817O'Donnell, C.P., E.D. King, A.R. Schwartz, J.L. Robotham and P.L. Smith,19947718191828He, J., M.H. Kryger, F.J. Zorick, W. Conway and T. Roth,19881914Williams, A.J., D. Houston, S. Finberg, C. Lam, J.L. Kinney and S. Santiago,19855510191022Hirshkowitz, M., I. Karacan, A. Gurakar and R.L. Williams,198912223232Chin, K., K. Shimizu, T. Nakamura, N. Narai and H. Masuzaki et al.,1999100706712O'Donnell, C.P., C.G. Tankersley, V.P. Polotsky, A.R. Schwartz and P.L. Smith,2000119163170Burack, B.,1984107543548Grunstein, R., I. Wilcox, T.S. Yang, Y. Gould and J. Hedner,199317533540National Commission on Sleep Disorders Research (NCSDR),1993pp: 302pp: 302