Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2004.110.114Catha edulis
Forsk) Extracts on Human T Lymphoblastoid Cell Line]]>BarkwanS.S. BarnettC.R. BarnettY.A. TomkinsP.T. FokunangC.N. 2200442This paper reports on an investigation of the cytotoxic and genotoxic potential of khat extract using a human T lymphoblastoid cell line (CEM). Exponentially growing CEM cells were cultured for 12 h in the presence of khat extract (0-2000 μg ml-1). Statistically significant, dose-dependent increases in; CEM cell death at dose (> 400 μg ml-1), in DNA damage at dose (>200 μg ml-1) and in micronuclei frequency, at dose (>200 μg ml-1) were observed. The genetic damage effects of khat extract on human cell line observed in this study could serve as a major contribution towards the understanding and creating of awareness of an increased risk of cancer amongst long-term khat consumers.]]>Kalix, P.,198415179187Kalix, P. and O. Braenden,198537149164Al-Meshal, I.A., M. Tariq, N.S. Parmer and A.M. Ageel,198517379380Kabarity, A. and G. Malallah,1980Allium cepa root tips.]]>45733738Al-Meshal, I.,1987Catha edulis (Khat), on the meristematic region of Allium cepa root tips.]]>25451454Kamel, A.H., E.E.S. Hussain and E.M. Hammouda,1967366263Halbach, H.,1972322129De Hondt, H.A., A.M. Fahmy and S.A. Abdelbaset,19846851860Soufi, H.E., M. Kameswaran and T. Malatani,1991105643645Foley, G.E. and H. Lazarus,1967in vitro of continuos culture of human lymphoblasts (CCRE-CEM) to chemotherapeutic agents.]]>16659674Barnett, Y.A., L.A. Brennan, F. O'Farrell, B.M. Hannigan .199537273281Fenech, M. and A.A. Morely,19851472936Gunaid, A.A., A.A. Sumairi, R.G. Shidrawi, A. Al-Hanaki and M. Al-Haimi et al.,199571409410Islam, M.W., A.O. Al-Shabanah, M.M. Al-Harbi and A.N.M. Al-Gharably,1994Catha edulis Forsk) in rats]]>175168Al-Ahdal, M.N., T.J. McGarry and M.A. Hannan,1988Catha edulis) extract on cultured mammalian cells: Effects on macromolecule biosynthesis.]]>204317322Reed, J.D.,19957315161528Sakagam, H., N. Kuribayashi, M. Inda, T. Sakagam and M. Takeda et al.,19951521212128Casalini, C., M. Lodovici, C. Briani, G. Paganelli, S. Remy, V. Cheynier and P. Dolara,199938190195Warner, T.E. and E.A. Azen,19882699102O'Gara, R. and C. Lee,197146131131O'Gara, R. 19682822722272Morton, J.F.,199259739765Chung, K.T., T.Y. Wong, C.I. Wei, Y.W. Huang and Y. Lin,199838421464Sharma, D.,199997360364Zheng, G.Q.,1994Artemisia annua.]]>605457Tariq, M., I.A. Al-Mesheal, N.S. Parmars, A.M. Ageel and S. Qureshi,1986Catha edulis) in Swiss Albino mice.]]>5381382Drake, P.H.,1988331532533Morton, J.F.,19791979pp: 129137Singh, N.P., M.T. McCoy, R.R. Tice and E.L. Schneider,1988175184191