Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2002.77.81HannaLaila S. IbrahimIbrahim I. MekyNefissa H. MattaTahany F. 2200222This study was performed to analyze the effect of menopause and osteoporosis on some hormone and biochemical markers of bone turnover. Eleven young adult premenopausal women (mean age 27.3 ± 0.9 years); 26 premenopausal women (mean age 41.5 ± 0.7 years); 17 perimenopausal women (mean age 48.8 ± 0.7 years); 26 postmenopausal women (mean age, 56.2 ± 2.4 years, menopause duration, 9.7 ± 1.9 years); and 11 postmenopausal osteoporotic women (mean age 73.7 ± 2.3 years, menopause duration, more than 15 years) were recruited for this study. Serum was assayed for estradiol (E2) follicle stimulating and luteinizing hormones (FSH and LH), insulin-like growth hormone factor-1 (IGF-1), total alkaline phosphatase (TALP) and osteocalcin or bone galacto-protein (BGP). The obtained data indicated that the measurements of E2 , FSH and LH are closely correlated with the bone formation markers IGF-1 and TALP. IGF-1, TALP and BGP are proved to have a good performance for bone formation in the increased bone turnover status.]]>Adashi, E.Y., C.E. Resnick, A.J. D'Ercole, M.E. Svoboda and J.J. van Wyk,19856400420Bahn, A.K.,1972Bauer, D.C., C. Rosen, J. Cauley and S.R. Cummings,199823561562Christiansen, C., B.J. Riis and P. Rodbro,199013540Christiansen, C., B.J. Riis and P. Rodbro,19871611051108Cole, H.W., S. Chandrasekhar, H.M. Hsuing, M.L. Heiman and M. Sato,19942) and raloxifene in the ovariectomized (OVX) rat are dependent on an intact pituitary.]]>95758Cummings, S.R., W.S. Browner, D. Bauer, K. Stone, K. Ensrud, S. James and B. Ettinger,1998339733738Delmas, P.D.,19929159S63SEriksen, E.F., D.S. Colvard, N.J. Berg, M.L. Graham, K.G. Mann, T.C. Spelsberg and L. Riggs,19882418486Eriksen, G.F., V.G. Garzo and D.A. Magoffin,198969716724Greendale, G.A., S. Delstein and E.B. Connor,19971218331843Greendale, G.A. and H.L. Judd,199341426436Gurlek, A. and O. Gediko,200124408414Heaney, R.P., R.R. Recker and P.D. Saville,197892964970Ho, K.Y., W.S. Evans, R.M. Blizzard, J.D. Veldhuis and G.R. Merrian et al.,1987645158Hsu, C.J. and J.M. Hammond,1987in vitro.]]>120198207Jilka, R.L., G. Hangoc, G. Girasole, G. Passeri and D.C. Williams et al.,19922578891Kassem, M., L.J.M. Melton III and B.L. Riggs,19961996pp: 691-702pp: 691-702Keen, R.W., T. Nguyen, R. Sobnack, L.A. Perry, P.W. Thompson and T.D. Spector,19966399406Kurland, E.S., F. Chan, D. Vereault, C.J. Rosen and J.P. Bilezikian,19961113231324Langlois, J.A., C.J. Rosen, M. Visser, M.T. Hannan, T. Harris, P.W.F. Wilson and D.P. Kiel,19988342574262Lian, J.B. and C.M. Gundberg,1988226267291Manolagas, S.G. and R.L. Jilka,1995332305311Ohishi, T., M. Takahashi, K. Kushida, K. Yamazaki, H. Hoshino, A. Kitazawa and T. Inoue,199824259267Oursler, M.J., C. Cortese, P. Keeting, M. Anderson, S.K. Bonde, B.L. Riggs and B.L. Spelsberg,199112933133320Pacifici, R., J.L. Vannice, L. Rifas and R.B. Kimble,19937711351141Reed, M.J., L. Topping, N.G. Coldham, A. Purolit, M.W. Ghilchik and V.H.T. James,199344589596Rosen, C.J.,19994513841390Rosen, C.J. and C. Conover,19978239193922Wand, J.S., J.R. Green, R. Hesp, J.N. Bradbeer and P.N. Sambrook et al.,199217361375Watts, N.B.,19994513591368