Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2001.327.333Fayyaz KhanMuhammad Farid KhanMohammad AshfaqMuhammad KhanGul Majid 5200115The objective of this investigation was to synthesize and characterize some
substitutive derivatives of Tranexamic Acid (TA) and their copper (II) complexes.
N-Phthaloyltranexamic Acid (A-1), N-Acetyltranexamic Acid (A-2), Di-Tranexamate Diaquo Copper (II) (C-1), Di-N-Phthaloyltranexamate Diaquo
Copper (II) (C-2) and Di-N-Acetyltranexamate Diaquo Copper (II) (C-3) were
synthesized, using novel and reproducible procedures. These compounds were
characterized by exploiting the techniques such as Fourier Transform Infra Red
(FTIR) Spectroscopy, Mass Spectroscopy (MS) and FT 1H NMR. Different
methods, reported in the literature, have successfully been applied for qualitative
and structural characterization of these compounds. C-1 showed unidentate
bonding of carboxylic group to copper (II) while C-2 and C-3 indicated bidentate
bonding of carboxylate group to copper (II).]]>Ahmad, B.U.D., M.A. Malana, N.H. Rama and M.T. Hussain,200022151154Anthony, J.H., W.G. Petter and R.T. Austin,19885th Edn.,pp: 1230-1231pp: 1230-1231Daidone, G., D. Raffa, S. Plescia, M. Matera, A. Caruso, V. Leone and M. Amico-Roxas,198944465473Rich, D.H., P.D. Gesellchen, A. Tong, Al Cheung and C.K. Buckner,19751810041010Fahmy, H.H. and W. El-Eraki,200124171179Khan, G.M., K.A. Javid and M.F. Khan,1997284551Khan, G.M., K.A. Javid and M.F. Khan,199728301304Nakanishi, A.,19995th Edn.,pp: 139-144pp: 139-144Pang, H., J.R. Zhang, X. Shuai and J.H. Wang,19987110111Pavia, D.L., G.M. Lampman and G.S. Kriz,1979pp: 157pp: 157Rao, C.M., A. Kumar and D.R. Kulkarni,199888273278