Journal of Medical Sciences1682-44741812-5727Asian Network for Scientific Information10.3923/jms.2001.193.199Majid KhanGul WazirFarmanull ZhuJia-bi 4200114The objective of this study was to investigate the influence of temperature on the
optimization process of the formation of inclusion complexes, preparation and
characterization of inclusion complexes between ibuprofen (IBF) and β-cyclodextrin (β-CD), and the evaluation of different complexation methods.
Inclusion complexes in the solid powdered forms were prepared by homogenous
coprecipitation-evaporation (CE), coprecipitation-centrifugation (CC), spray
drying (SD), and freeze drying (FD) methods. Scanning electron microscopy
(SEM), differential scanning calorimetry (DSC), x-ray diffractometry and I R
absorption spectroscopy were exploited to characterize the solid complexes. In
vitro dissolution experiments were conducted in distilled water using the USP
XXII paddle method. The f2-metric technique was employed for the determination
of equivalency between the dissolution profiles through multiple linear regression
computer soft ware program. Temperature was found to have an important role in
the optimization process of the complex formation. A marked difference in the
properties of the complexes was observed due to their methods of preparation. In
general, the solubility and dissolution rates of the complexes formed were greatly
enhanced over that of the physical mixture, which, in turn, could demonstrate
higher dissolution rates than those displayed by the pure drug. The freeze drying
method was found to provide with the highest dissolution rates among the
methods used in this investigation.]]>Amdidoch, D., H. Darrouzet, D. Duchene and M.C. Poelmano,198954175179Boymond, C. and H. Redolphi,19942021832193Cramar, F., W. Saenger and H.C. Spatz,19671a. The formation of inclusion compounds of α-cyclodextrin in aqueous solutions. Thermodynamics and kinetics.]]>891420Green, A.R., E.S. Mullar and J.K. Guillory,199180186189Higuchi, T. and K.A. Connors, 19654212217Hasegawa, A., R. Kawamura, H. Nakagawa and I. Sugimoto,19863421832190Moore, J.W. and H.H. Flanner,1996206474Labenderia, J.J.T., M.E. Lopez, L.S. Penin and J.L.V. Jato,1993in vitro dissolution behavior.]]>39255259Loftsson, T., T.K. Guomundsdottir and H. Frioriksdottir,199622401405McDonald, C., L. Palmer and M. Boddy,19962210251029Najib, N. and M. Suleiman,19851121692181Nakai, Y.,19861210171039Nagarsenkar, M.S. and H. Shenai,199622987992Puglisi, G., N.A. Santagati, R. Pignatello, C. Ventura and F.A. Bottino et al.,199016395413Palmieri, G.F., P. Wehrle and A. Stamm,199319875885Peri, D., C.M. Wyandt, R.W. Cleary, A.H. Hickal and A.B. Jones,19942014011410Szejtli, J.,1982pp: 95pp: 95Sanghavi, N.M., K.B. Choudhari, R.S. Matharu and L. Viswanathan,199319701712Sherif, I., F. Badawy, A.L. Marshall, M.M. Ghorab and C.M. Adeyeye,199622959966Vromans, H., A.C. Eissens and C.F. Lerk,198935250255