Research Journal of Microbiology1816-4935xxxx-xxxxScience International10.3923/jm.2015.377.384Neurospora crassa from Machilipatnam Sea Water]]>KumarK. Ashok GousiaS.K. LathaJ. Naveena Lavanya 82015108The aim of present study is to study the anti-bacterial and fungal activities of Neurospora crassa, which is isolated from the marine sample collected from Machilipatnam coast of Andhra Pradesh, India. The fungus was isolated on PDA Media amended with chloramphenicol. Fungus was identified as, N. crassa by morphological and microscopic observations. Isolated fungus was inoculated into liquid medium for secondary metabolites production. Crude extract is characterized for biological activities. The TLC is performed to identify and purify the sub fractions in the extract. The same were tested against different pathogenic bacteria and fungi to determine the antibacterial and anti fungal activities. The study revealed that, among the fungal species used Neurospora crassa was found to be active against all bacterial and fungal strains tested. The collected crude extract of N. crassa showed 24 mm diameter zone against Aspergillus flavus, at concentration of 200 μg and the best activity was observed at a concentration of 200 μg against E. coli and Streptococci which showed 18 mm diameter. The TLC Neurospora crassa crude extract revealed 7 fractions. The selected organism which produces the compounds contains the biological activities, which include, anti-bacterial and anti fungal activities. Hence, we conclude that the compounds have high efficiency of anti microbial activity, which needs extensive attention in terms of new therapy. Neurospora crassa may lead to the discovery of pharmaceutically valuable products.]]>Anupama, M., T.V. Kumar and J.N.L. Latha,2014Neurospora crassa from marine water.]]>52226Awaad, A.S., A.J.A. Nabilah and M.E. Zain,2012Aspergillus terreus isolated from desert soil.]]>2618721877Coleman, J.J., S. Ghosh, I. Okoli and E. Mylonakis,20112011Blunt, J.W., B.R. Copp, M.H.G. Munro, P.T. Northcote and M.R. Prinsep,200421149Dreyfuss, M.M. and I.H. Chapela,19941994pp: 49-80pp: 49-80Samuel, P., L. Prince and P. Prabakaran,201118694Jensen, P.R. and W. Fenical,20002000pp: 6-29pp: 6-29Suseela, L., M. Anupama, B. Prudhvilal, T.V. Narasaiah and J.N.L. Latha,20145559565Hina, M.I., S. Dhanapal and D.S. Sekar,2015212Holler, U., A.D. Wright, G.F. Matthee, G.M. Konig, S. Draeger, H.J. Aust and B. Schulz,200010413541365Perkins, D.D. and R.H. Davis,2000Neurospora species for academic and commercial uses.]]>6651075109Yu, J.H. and N. Keller,200543437458Namikoshi, M., K. Akano, H. Kobayashi, Y. Koike, A. Kitazawa, A.B. Rondonuwu and S.B. Pratasik,2002881520Osherov, N. and G.S. May,2001199153160Rashmi, K., J.N.L. Latha, T.N. Sowjanya, P. Kiranmayi, M.V. Enugopal, C.P.S. Menon and P.M. Mohan,20038516721674Farag, R.S., Z.Y. Daw, F.M. Hevedi and G.S.A. El-Baroty,198952665667Zain, M.E., A.S. Awaad, A.A. Razak, D.J. Maitland, N.E. Khamis and M.A. Sakhawy,2009Aureobasidium pullulans isolated from Egyptian soil and their biological activity.]]>515821591