Research Journal of Microbiology1816-4935xxxx-xxxxScience International10.3923/jm.2012.227.234Amycolatopsis mediterranei]]>ManikyamA. NaseeruddinShaik SateeshL. VenkateshwarS. RaoL. Venkateswar 4201274Application of rifamycin as a broad spectrum antibiotic, due to its demand and high consumption is increasing in human therapy. Continuous efforts are being made to produce it in a cheaper way using different available raw materials. In the present study, agroindustrial residual products like cereal bran were screened for the production of rifamycin SV with Amycolatopsis mediterranei by solid state fermentation. Optimization of various cultural and physiological parameters using cereal bran was carried out in conventional method by one parameter at a time method. The results indicated that at 90% initial moisture level and optimum cultural conditions, the production of rifamycin SV was higher with finger millet bran as substrate and showed a yield of 246 mg/100 gds while using glucose as a carbon source. This study confirms that cereal bran can perform as well solid substrate comprising of available nutrients along with a suitable carbon source for various antibiotic and metabolite fermentations thereby decreasing the production costs.]]>Abd-Aziz, S., L.G.A. Ong, M.A. Hassan and M.I.A. Karim,2008Aspergillus niger FTCC 5003 using palm kernel cake as carbon source.]]>3297307Bussari, B., P.S. Saudagar, N.S. Shaligram, S.A. Survase and R.S. Singhal,2008Streptomyces clavuligerus NT4 using solid-state fermentation.]]>354958El-Enshasy, H.A., U.I. Beshay, A.I. El-Diwany, H.M. Omar, A.G.E. El-Kholy and R. El-Najar,2007713811389Ghisalba, O., J.A.L. Auden, T. Schupp and J. Nuesch,19841984pp: 281-327pp: 281-327Ghosh, P.K.,1992343242Holker, U., M. Hofer and J. Lenz,200464175186Jin, Z.H., J.P. Lin and P.L. Cen,2004Amycolatoposis mediterranei.]]>515901596Krishna, P.S.M., G. Venkateswarlu and L.V. Rao,1999Amycolatopsis mediterranei MTCC17.]]>20741743Lal, R. and S. Lal,199416211216Lotfy, W.A.,2007Acremonium chrysogenum grown on beet molasses: Optimization of process parameters through statistical experimental designs.]]>2112Maggi, N., C.R. Pasqualucci, R. Ballota and P. Sensi,196611285292Mahalaxmi, Y., T. Sathish, C. Subba Rao and R.S. Prakasham,2010Amycolatopsis sp. RSP 3 under SSF.]]>454753Nagavalli, M.,2009Amycolatopsis mediterranei (NCIM 5008).]]>2009Nisha, A.K. and K. Ramasamy,2008Tolypocladium inflatum (ATCC 34921).]]>7357359Oppolzer, W. and V. Prelog,19735622872314Oshoma, C.E. and M.J. Ikenebomeh,2005Aspergillus niger biomass from rice bran.]]>43236Pandey, A. and C.R. Soccol,199841379390Pasqualucci, C.R., V. Vigevani, P. Radaelli and G.G. Gallo,197059685687Rinehart, K.L. and L.S. Shield,197633231307Sayyad, S.A., B.P. Panda, S. Javed and M. Ali,2007Monascus purpureus MTCC 369 under submerged fermentation using Plackett-Burman design.]]>2601605Sensi, P. and J.E. Thiemann,196762159Sepkowitz, K.A., J. Rafalli, L. Riley, T.E. Kien and D. Armstrong,19958180199Singh, P., N. Nigam and A. Pandey,2009pp: 129-146pp: 129-146Singh, R., V. Kapoor and V. Kumar,2011Streptomyces sp. MSC702 (MTCC 10772).]]>3540553Soliman, H.M., A.D.A. Sherief and A.B. EL-Tanash,2012Aspergillus niger and Trichoderma viride using some agriculture residues.]]>74657Vastrad, B.M. and S.E. Neelagund,20113104111Venkateswarlu, G., P.S.M. Krishna and L.V. Rao,1999Amycolatopsis mediterranei (MTCC14).]]>202730Vohra, R.M. and S. Dube,1989477463466Raja, A. and P. Prabakarana,201117584