Research Journal of Microbiology1816-4935xxxx-xxxxScience International10.3923/jm.2011.310.321IbrahimMohammed A. MakkiyaAdil 4201164There is increasing evidence on the association of chronic bacterial infections with development of various types of cancers. Bacterial infections are involved in the processes and mechanisms leading to chronic inflammations, these are shown to cause molecular genomic damage and alterations which lead to transformation of normal cells to malignant cells. Moreover carcinogenic bacterial metabolites and toxins were found associated with development of various types of cancers. Furthermore recent findings are relating specific bacterial infections and inflammations with aberration of genomic DNA methylation. This article reviews various aspects which link chronic bacterial infections with chronic inflammations, development of cancers and their influence on aberration of genomic DNA methylation.]]>Alikhani, M.Y., N. Sadeghifard, S. Farajnia, M. Hajia, M.M. Aslani and A.R. Zamani,2007Helicobacter pylorifrom gastric biopsy specimens.]]>1041564159Allavena, P., C. Garlanda, M.G. Borrello, A. Sica and A. Mantovani,200818310Balkwill, F. and A. Mantovani,2001357539545Bobetsis, Y.A., S.P. Barros, D.M. Lin, J.R. Weidman and D.C. Dolinoy et al.,200786169174Browne, M. and T.M. Healy,19821517578Bouvard, V., R. Baan, K. Straif, Y. Grosse and B. Secretan et al.,200910321322Caygill, C.P., M. Braddick, M.J. Hill, R.L. Knowles and J.C. Sharp,19954187193Chiba, T., H. Marusawa, H. Seno and N. Watanabe,2008Helicobacter pylori infection.]]>2311751181Coussens, L.M. and Z. Werb,2002420860867Crowe, S.E.,2005213238Di Napoli, A., R. Petrino, M. Boero, D. Bellis and L. Chiandussi,1992Helicobacter pylori.]]>45796798Dore, M.P., G. Realdi, D. Mura, D.Y. Graham and A.R. Sepulveda,20024716381643Enroth, H., W. Kraaz, L. Engstrand, O. Nyren and T. Rohan,2000Helicobacter pylori strain types and risk of gastric cancer: A case-control study.]]>9981985Falsafi, T., R. Favaedi, F. Mahjoub and M. Najafi,2009Helicobacter pylori infection in children.]]>15484488Ferreccio, C., A. Rollan, P.R. Harris, C. Serrano and A. Gederlini et al.,2007Helicobacter pylori infection in a high-prevalence country.]]>16662667Grahn, N., M. Hmani-Aifa, K. Fransen, P. Soderkvist and H.J. Monstein,20055410311035Guarner, J., N. Kalach, Y. Elitsur and S. Koletzko,2010Helicobacter pylori diagnostic tests in children: Review of the literature from 1999 to 2009.]]>1691525Hamad, A.W.R., M.A. Ibrahim, S.I. Al-Mohtasib and K.N. Al-Kobasi,200941623Hirayama, K. and J. Rafter,199976391394Hodge, D.R., W. Xiao, P.A. Clausen, G. Heidecker, M. Szyf and W.L. Farrar,20012763950839511Hodge, D.R., B. Peng, J.C. Cherry, E.M. Hurt and S.D. Fox et al.,20056546734682Huang, S., J.Y. Li, J. Wu, L. Meng and C.C. Shou,20017266269Ibrahim, M.A., N. Saleh, K.M. Mousawy, N. Al-Hmoud, E. Archoukieh, H.W. Al-Obaide and M.M. Al-Obaidi,200943541Ibrahim, M.A.,20109459468Ibrahim, M.A.,20106188201Ibrahim, M.A., N. Saleh, E. Archoukieh, H.W. Al-Obaide, M.M. Al-Obaidi and H.M. Said,201061926Ibrahim, M.A., N.M. Saleh, M.M. Al-Obaidi and E. Archoukieh,20102010pp: 6670Khedmat, H., M. Amini, A.M. Jafari, F.N. Afshar and M.J. Soltanpoor et al.,2007In vitro susceptibility testing of Helicobacter pylori to metronidazole, amoxicillin, tetracycline and ciprofloxacin in Iran.]]>2947953Kiehlbauch, J., R.V. Tauxe, C.N. Baker and I.K. Wachsmuth,1994Helicobacter cinaedi associated bacteremia and cellulitis in immunocompromised patients.]]>1219093Kumar, S., S. Kumar and S. Kumar,200693633639Kung, I.T., I.O. Lui, S.L. Loke, M.A. Khin, C.K. Mok, W.K. Lam and S.Y. So,19859391400Kuper, H., H.O. Adami and D. Trichopoulos,2000248171183Lax, A.J.,20053343349Lazcano-Ponce, E.C., J.F. Miquel, N. Munoz, R. Herrero and C. Ferrecio et al.,200151349364Lijinsky, W.,197656772Maeda, H. and T. Akaike,199863854865Mager, D.L.,200641414Mantovani, A.,201010369373Mantovani, A., C. Garlanda and P. Allavena,201042161170Mantovani, A., B. Savino, M. Locati, L. Zammataro, P. Allavena and R. Bonecchi,2010212739Moghaddam, M.N. and M.N. Moghaddam,2008Helicobacter pylori clinical isolates in a hospital in Iran and protein pattern of two strains showing differences in susceptibility.]]>8466469Mueller, M.M.,200642735744Nguyen, I.S., J. Biarc, A. Pini, F. Gosse and S. Richert et al.,2006Streptococcus infantarius and colonic cancer: Identification and purification of cell wall proteins putatively involved in colorectal inflammation and carcinogenesis in rats.]]>1289257261Orlicek, S.L., D.F. Welch and T.L. Kuhls,1993Helicobacter cinaedi in a neonate.]]>31569571Ohshima, H. and H. Bartsch,1994305253264Parsonnet, J.,1995103263268Payne, R.J., M.A. Nowak and B.S. Blumberg,1992159215240Pisani, P., D.M. Parkin, N. Munoz and J. Ferlay,19976387400Ponzetto, A., R. Pellicano, N. Leone, M.A. Cutufia and F. Turrini et al.,200054275277Robbins, S., V.P. Chuang and T. Hersh,1988Salmonella typhus.]]>83675678Rollins, B.J.,200642760767Rosin, M.P., S. Saad el Din Zaki, A.J. Ward and W.A. Anwar,1994305283292Sadeghifard, N., M.M. Aslani and A. Ghasemi,2006Helicobacter pylori.]]>611461149Salaspuro, M.P.,200340183208Saleh, N., M.A. Ibrahim, E. Archoukieh, A. Makkiya, M. Al-Obaidi and H. Alobydi,20109170175Samaras, V., P.I. Rafailidis, E.G. Mourtzoukou, G. Peppas and M.E. Falagas,20104267281Sasazuki, S., M. Inoue, M. Iwasaki, T. Otani and S. Yamamoto et al.,2006Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: A nested case-control study.]]>1513411347Schetter, A.J., N.H.H. Heegaard and C.C. Harris,2010313749Schottenfeld, D. and J. Beebe-Dimmer,2006566983Schwartz, L., J. Balosso, F. Baillet, B. Brun, J.P. Amman and A.J. Sasco,200258340346Shacter, E. and S.A. Weitzman,200216217226Shukla, V.K., H. Singh, M. Pandey, S.K. Upadhyay and G. Nath,200045900903Shin, C.M., N. Kim, Y. Jung, J.H. Park and G.H. Kang et al.,2010Helicobacter pylori infection in aberrant DNA methylation along multistep gastric carcinogenesis.]]>10113371346Snyder, D.L., M. Pollard, B.S. Wostmann and P. Luckert,199045B52B58Stanley, J., D. Linton, A.P. Burnens, F.E. Dewhirst and S.L. On et al.,1994Helicobacter pullorum sp. nov.-genotype and phenotype of a new species isolated from poultry and from human patients with gastroenteritis.]]>14034413449Stenvinkel, P., M. Karimi, S. Johansson, J.Axelsson and M. Suliman et al.,2007261488499Stutes, M., S. Tran and S. DeMorrow,20071364656469Suzuki, H., M. Toyota, Y. Kondo and Y. Shinomura,20095125569Taylor, D.N. and M.J. Blaser,1991Helicobacter pylori infection.]]>134259Vakevainen, S., S. Mentula, H. Nuutinen, K.S. Salmela, H. Jousimies-Somer, M. Farkkila and M. Salaspuro,200237648655Valle, J., K. Seppala, P. Sipponen and T.U. Kosunen,1991Helicobacter pylori, a morphometric study.]]>2610571065Van der Auwera, I., C. Bovie, C. Svensson, R. Limame and X.B. Trinh et al.,2009822522259Zur Hausen, H.,2006Streptococcus bovis: Causal or incidental involvement in cancer of the colon.]]>1191112Winter, S., C. Loddenkemper, A. Aebischer, K. Rabel and K. Hoffmann et al.,2010Helicobacter pylori-induced inflammation.]]>8811691180Wistuba, I.I. and A.F. Gazdar,20044695 706