Research Journal of Microbiology1816-4935xxxx-xxxxScience International10.3923/jm.2010.44.49Streptococcus sp.]]>RajaA. PrabakaranP. GajalakshmiP. 1201051The objective of this study is to isolate and screen new antibiotic producing psychrophilic Actinomycetes and to find out their antimicrobial activity against Streptococcus by agar well diffusion method. The antibacterial activities of isolated actinomycetes were found against S. mutans and S. oralis. A total Six Actinomycetes were isolated from the soil sample through crowded plate technique were subjected to primary screening and identified as Intrasporangium sp., Dactyl sporangium sp., Micromonospora sp., Streptoverticilium sp. and two Streptomyces sp. The bacterial species were isolated from fifty of tooth samples which are collected from the dental hospital and identified as S. mutans and S.oralis. The identification of test pathogenic bacteria is confirmed by hemolytic activity on blood agar plates and biochemical tests. The test organism S. mutans is highly sensitive to Dactylsporangium sp. and the S. oralis sensitive to streptomyces. The Dactylsporangium sp. produce pertinacious substance which is responsible for antimicrobial activity. Other strains are producing non pertinacious substance. This is the first time we report that the species other than Streptomyces showed antibacterial activity against streptococcus associated with dental disease.]]>Bachmann, S.L. and A.J. McCarthy,1991Thermomonospora fusca.]]>5721212130Berdy, J.,200558126Charan, R.D., G. Schlingmann, J. Janso, V. Bernan, X. Feng and G.T. Carter,2004Micromonospora sp.]]>6714311433Cowen, L.E.,20086187198Hopwood, D.A., M.J. Buttner, M.J. Bibb, T. Kieser and K.K. Charter,20001142Kubo, I., H. Muroi and M. Himejima,1993Streptococcus mutans of mate tea flavor components.]]>41107111Law, V., W.K. Seow and G. Townsen,20075293100NCCLS-National Committee for Clinical Laboratory Standards,1999Moncheva, P., S. Tishkov, N. Dimitrova, V. Chipeva, S.A. Nikolova and N. Bogatzevska,20023314Rogers, A.H.,2008Wells, S.J., J. O'Sullivan, C. Aklonis, H.A. Ax and A.A. Tymiak et al.,1992Dactylosporangium sp.]]>4518921898Shirling, E.B. and D. Gottlieb,1966Streptomyces species.]]>16313340Staneck, J.L. and G.N. Roberts,197428226231Strohl, W.R.,20042004pp: 336-355pp: 336-355Nakazawa, Y., M. Uchino, Y. Sagane, H. Sato and K. Takano,20091644348Hancock, R.E.W.,200762828Zamanian, S., G.H. Shahidi Bonjar and I. Saadoun,2005Streptomyces plicatus (strain 101) against Erwinia carotovora from Iran.]]>4114120Kawato, M. and R.A. Shinobu,19598114114Pearson and Carol,20082008Taechowisan, T., A. Sitthipanya, A. Wanbanjob and P. Tantiwachwuttikul,2008Streptomyces sp. ST8 on the growth, adherence and glucosyltransferase of Streptococcus mutans.]]>84351