Research Journal of Microbiology1816-4935xxxx-xxxxScience International10.3923/jm.2007.524.529 Lactobacillus acidophilus and Lactobacillus bulgaricus Isolated from Iranian Yoghurt on 2-Nitrofluorene]]>MobarezAshraf MohabatiDoustReza HosseiniHassanZuhair MohamadKamaliSaminea 6200726The antimutagenic activity of Lactobacillus bulgaricus and acidophilus to potent mutagen, 2-nitrofluorene was examined by the modified Ames test using Salmonella typhimurium TA100. The results showed that the supernatants, heat killed cells and viable cells of Lactobacilli, preincubated with mutagenic factor such as 2-nitrofluorene, displayed characteristic antimutagenic activities. L. bulgaricus and L. acidophilus cells showed 98 and 64% antimutagenic activity against 2-nitrofluorene, respectively. Antimutagenic activities of Lactobacilli were higher than their supernatants. All the strains, heated for 15 min at 100°C, antimutagenic activities were reduced by 36-47%.]]>El-Gawad, A.I.A., E.M. El-Sayed, S.A. Hafez, H.M. El-Zeini and F.A. Saleh,2004in vitro and in vivo in a mouse tumour model.]]>928186Asahara, N., X.B. Zhang and Y. Ohta,199258395401Brady, L.J., D.D. Gallaher and F.F. Busta,2000130410S414SDe-Moreno-de-LeBlanc, A. and G. Perdigon,2005291524Femia, A.P., C. Luceri, P. Dolara, A. Giannini and A. Biggeri et al.,2002L. rhamnosus and B. lactis on azoxymethane induced colon carcinogenesis in rats.]]>2319531960Goldin, B.R. and S.L. Gorbach,1980L. acidophilus dietary supplements on DMH induced intestinal cancer in rats.]]>64263265Haza, A.I., A. Zabala, N. Arranz and P. Mrales,2005Lactobacillus salivarius strain of human origin.]]>11251259Hsieh, M.L. and C.C. Chou,20061114347Marona, D. and G. Pedrigon,20041096104Lidbeck, A., E. Overvik, J. Raftar, C.E. Nord and J.A. Gustafsson,1992Lactobacillus acidophilus supplements, on mutagen excretion in feces and urine in humans.]]>55967Maron, D.M. and B.N. Ames,1983Salmonella mutagenicity test.]]>113173215Nadathur, S.R., S.G. Gould and A.T. Bakalinsky,1995334213224Nadathur, S.R., J.R. Carney, S.J. Gould and A.T. Balkalinsky,1996359179189Norat, T. and E. Riboli,200357117Parvez, S., K.A. Malik, S.A. Kang and H.Y. Kim,200610011711185Scheepers, P.T., M.M. Straetemans, J.P. Koopman and R.P. Bos,19941023941Perdigon, G., A.M. de LeBlanc, J. Valdez and M. Rachid,200256S65S68Pool, Z.B., C. Neudeker, I. Domizlaff, S. Ji and U. Schillinger et al.,1996Lactobacillus and Bifidobactrium mediated antigenotoxicity in colon of rats.]]>26365380Rachid, M.M., N.M. Gobbato, J.C. Valdez, H.H. Vitalone and G. Perdigon,200215209216Rhee, C.H. and H.D. Park,2001Lactobacillus plantarum KLAB21.]]>334213224Lo, P.R., R. Chuiyu, C.C. Chou and Y.H. Tsai,2002Bifidobacteria against Banzo (a) Pyrene.]]>94148153Wollowski, I., A.T. Balkalinsky, C. Neudecker and B.L. Pool-Zobel,19991297782Zhang, X.B. and Y. Ohta,19907327022710