Journal of Food Resource Science2224-3550xxxx-xxxxAsian Network for Scientific Information10.3923/jfrs.2015.10.16TianJing XinWang KaiMa Shu-guangFang 1201541Multiple Strains of lactic acid bacterial, Lactobacillus acidophilus LA85, Lactobacillus plantarum Lp90, Bifidobacterium longum BL21 and Bifidobacterium lactis BLa80 exhibit probiotic potential as antiallergy agents, both in vitro and in vivo. Although, some lactic acid bacteria have exhibit probiotic effect, as new strains, their safety still requires evaluation when isolated from infant faeces or pickled cabbage. The safety and toxicology evaluation of this Lactic Acid Bacterial (LAB) powder was subject to a bacterial reverse mutation assay and a short-term oral toxicity study. The LAB powder product exhibited mutagenic potential in Salmonella Typhimurium strains TA97, TA98, TA100 and TA102 (with or without metabolic activation). In the short-term oral toxicity study, rats received a normal dosage of 70 mg kg1 day1 (approximately CFU kg1 day1) or a high dosage of 700 mg kg1 day1 (approximately CFU kg1 day1 ) for 30 days. The result of 30 days feed test indicated that rat growth in good condition, including behaviour, growth, feed and water consumption, haematology, clinical chemistry indices, organ weights or histopathologic analysis of the rats. These studies have demonstrated that the consumption of multiple bacterial strains (LA85, Lp90, BL21, BLa80) is not associated with any signs of mutagenicity of S. typhimurium or toxicity in rats, even after consuming large quantities of bacteria.]]>Donohue, D.C.,200615563569De Flora, S., A. Camoirano, F. D'Agostini and R. Balansky,1992267183192Salminen, S., A. von Wright, L. Morelli, P. Marteau and D. Brassart et al.,19984493106Jones, M.L., C.J. Martoni, S. Tamber, M. Parent and S. Prakash,2012Lactobacillus reuteri NCIMB 30242 in a yogurt formulation: A randomized, placebo-controlled, double-blind study.]]>5022162223Hudault, S., V. Lievin, M.F. Bernet-Camard and A.L. Servin,1997in vitro and in vivo by Lactobacillus casei (strain GG) against Salmonella typhimurium C5 infection.]]>63513518Meng, Z., G. Cheng and M. Liu,1993Lactobacillus and People Health.]]>Coconnier, M.H., V. Lievin, E. Hemery and A.L. Servin,1998Helicobacter infection in vitro and in vivo by the human Lactobacillus acidophilus strain LB.]]>8645734580Follmann, W. and S. Lucas,2003in vitro mutagenicity test system.]]>77298304Hirose, Y., S. Murosaki, Y. Yamamoto, K. Muroyama, Y. Miwa, A. Fujishima and B. Lynch,2009Lactobacillus plantarum L-137.]]>54214220Zhang, M.S., I.S. Bang and C.B. Park,2012Periploca sepium bge. In bacterial reverse mutation (ames) test, chromosomal aberration and micronucleus test in mice.]]>2012Tsai, C.C., M.H. Chen, T.H. Liu, C.G. Chau, L.T. Chang and H.Y. Tsen,2004Lactobacillus acidophilus LAP5 in a 28-day feeding study in Wistar rats.]]>24268280Tsai, C.C., T.H. Liu, M.H. Chen, C.C. Tsai and H.Y. Tsen,2004Enterococcus faecium strain TM39 in vitro and in vivo.]]>4216011609Szabo, N.J., L.C. Dolan, G.A. Burdock, T. Shibano and S. Sato et al.,2011Lactobacillus pentosus strain b240.]]>49251258Swendseid, M.E.,19871987pp: 205211