Journal of Environmental Science and Technology1994-78872077-2181Asian Network for Scientific Information10.3923/jest.2020.131.138KusriniIna SamsudinMohamad BrotoPrihatin KumorowulanSuryati SupadmiSri Dwi LaksonoAgung 32020133Background and Objective: Iodine excess is a risk factor in thyroid dysfunction. The purpose of the study was to identify the prolonged effect of iodine excess on thyroid dysfunction in areas with high iodine on natural resources in Indonesia. Materials and Methods: A cross-sectional study was conducted in two districts. This study included 500 School-Aged Children (SAC) 06-12 years of age for 25 clusters in each district, were included in this study. Logistic regression was performed to estimate the risk of thyroid dysfunction. Results: Demak and Grobogan were classified as iodine excess area with Median Urine Iodine Concentration (MUIC) is 446, 453 μg L1, iodine water at 112.3, 414.5 ppb. Profile thyroid dysfunction was described as subclinical hypothyroidism, 31.5, 36.3%, secondary hypothyroidism, 25.5, 6.9%, respectively. While autoimmune thyroiditis was not shown, overt and subclinical hyperthyroidism was found in Grobogan only 0.4;1.4%. Excess iodine raises the risk of subclinical hypothyroidism, Adjusted Odd Ratio (AOR): 1.97 (CI:1.1-3.4) and secondary hypothyroidism, AOR: 2.44 (CI:1.5-3.9). Conclusion: Subclinical hypothyroidism is the most prevalent thyroid disease in iodine excess area due to elevated iodine in groundwater.]]>Vanderpump, M.,201414s7s11WHO,20073rd Edn.,Pages: 99Pages: 99Zimmermann, M.B. and K. Boelaert,20153286295Tenpenny, K., C. Trent, P. Sutherland, L. Van Middlesworth, B. Williams-Cleaves and L. Braverman,200915298301Kučera, J.,20092009pp: 15-27pp: 15-27Rasmussen, L.B., L. Ovesen, I. Bülow, T. Jørgensen, N. Knudsen, P. Laurberg and H. Perrild,2002876169Fuge, R.,1996113201211Sack, J., I. Kaiserman, T. Tulchinsky, G. Harel and R. Gutekunst,201113185190Tang, Q., Q. Xu, F. Zhang, Y. Huang and J. Liu et al.,2013135117123Rosenthal, E. and A. Mates,19861591600Duan, L., W. Wang, Y. Sun and C. Zhang,20162016Farebrother, J., M.B. Zimmermann, F. Abdallah, V. Assey and R. Fingerhut et al.,20182811981210Roti, E. and E.D. Uberti,200411493500Konno, N., H. Makita, K. Yuri, N. Iizuka and K. Kawasaki,199478393397Health M of, National Institute Health Research And Development M of H.,20072007Kusrini, I.,M. Samsudin, M. Musoddaq, S. Purwoko and B. Budiman,2018177584Levy, P.S. and S. Lemeshow,20084th Edn.,Pages 576Pages 576Yang, F., Z. Shan, X. Teng, Y. Li and H. Guan et al.,2007156403408Nagataki, S.,200818667668Katagiri, R., X. Yuan, S. Kobayashi and S. Sasaki,20172017Pearce, E.N., A.R. Gerber, D.B. Gootnick, L.K. Khan, R. Li, S. Pino and L.E. Braverman,20028754995502Lv, S., L. Xie, D. Xu, Y. Wang, L. Jia and Y. Du,201652296304Bürgi, H.,201024107115Leung, A.M. and L.E. Braverman,201410136142Wolff, J. and I. Chaikoff,194842468471Eng, P.H.K., G.R. Cardona, S.L. Fang, M. Previti and S. Alex et al.,199914034043410Rasmussen, L.B., L. Ovesen, I. Bülow, T. Jorgensen, N. Knudsen, P. Laurberg and H. Perrild,20027610691076Zimmermann, M.B., I. Aeberli, M. Andersson, V. Assey and J.A.J. Yorg et al.,20139812711280Prakash R.,200582708709Zimmermann, M.B., Y. Ito, S.Y. Hess, K. Fujieda and L. Molinari,200581840844Zhao, J., P. Wang, L. Shang, K.M. Sullivan, H.F. Van Der and G. Maberly,20009016331635Luo, Y., A. Kawashima, Y. Ishido, A. Yoshihara and K. Oda et al.,2014151289512912Burek, C.L. and M.V. Talor,200933183189Teng, X., Z. Shan, W. Teng, C. Fan, H. Wang and R. Guo,200995159Suzuki, H., T. Higuchi, K. Sawa, S. Ohtaki and Y. Horiuchi,196550161176Sawa, K.,196541633642,583Koukkou, E.G., N.D. Roupas and K.B. Markou,2017108136146Xu, C., F. Wu, C. Mao, X. Wang and T. Zheng et al.,2016755057Hemminki, K., X. Li, J. Sundquist and K. Sundquist,201034J307J313Stanbury, J.B., A.E. Ermans, P. Bourdoux, C. Todd and E. Oken et al.,1998883100Budiman, B. and D. Widagdo,2006301324