Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2016.65.711]]>AlthnaianThnaian 32016163Because of AFB1 effects on antioxidant enzyme activities and gene expression in kidneys have not been completely elucidated, the current study was designed to investigate the histopathological picture and activities and gene expression of antioxidant enzymes in kidneys of rats. Therefore, 20 rats were randomly divided into two equal groups. Rats in the first group served as control whereas rats in the second group received single i.p., dose of AFB1 (3 mg kg1 b. wt.). Kidney damage and oxidative stress were observed in AFB1-intoxicated rats as indicated by a significant elevation in thiobarbituric acid reactive substances (TBARS), reduction of reduced glutathione (GSH) concentration, reduction in the activities of antioxidant enzymes namely catalase (CAT), total superoxide dismutase (SOD), glutathione peroxidase (GPX) and glutathione-s-transferase (GST) and down-regulation of gene expression of these antioxidant enzymes compare to control. Kidney sections of rats intoxicated with AFB1 showed swelling and vacuolar cytoplasm of distal tubules and desquamated distal tubular cells. In conclusion, AFB1 may exert its toxicity to kidney tissues by induction of lipid peroxidation and inactivation and down-regulation of gene expression of antioxidant enzymes.]]>Abdulmajeed, N.A.,20111 induced renal and cardiac damage.]]>4110Ahmad, H., J. Tian, J. Wang, M.A. Khan, Y. Wang, L. Zhang and T. Wang,20126071117120Al-Ghasham, A., H.S. Ata, S. El-Deep, A.R. Meki and S. Shehada,2008Nigella sativa on Aflatoxin B1 toxicity.]]>22644Al-Habib, M.F.M., A.A. Jaffar and H.H. Abdul-Ameer,20071-induced kidney damage in rats.]]>49147150Antonyak, H., C. Olijnyk, N. Koval, R. Fedyakov, M. Dosviadchynska, I. Panchuk and B. Chekh,2015694148Antunes, N.L., M.M. Souweidane, E. Li, M.K. Rosenblum and P.G. Steinherz,200226305308Atessahin, A., I. Karahan, S. Yilmaz, A.O. Ceribasi and I. Princci,200348637642Bancroft, J.D. and M. Gamble,20025th Edn.,Pages: 796Pages: 796Busby, W. and G. Wogan,19841984pp: 954-1136pp: 954-1136Choi, J.J., B.S. Moffett, E.J. McDade and D.L. Palazzi,201130347349Choy, W.N.,19931 and its implications to quantitative cancer-risk assessment.]]>296181198Deabes, M.M., H.R. Darwish, K.B. Abdel-Aziz, I.M. Farag, S.A. Nada and N.S. Tawfek,2012Lactobacillus rhamnosus GG on aflatoxins-induced toxicities in male albino mice.]]>2132140Devendran, G. and U. Balasubramanian,201116169El‐Bahr, S.M.,20151.]]>29134140El-Bahr, S.M., M.A. Embaby, A.A. Al-Azraqi, A.M. Abdelghany, Y.A. Hussein, F.A. Hizab and T.A. Althnaian,20151-induced toxicity in rats: A biochemical and histopathological study.]]>56372El-Demerdash, F.M., M.I. Yousef, F.S. Kedwany and H.H. Baghdadi,20044215631571El-Mahalaway, A.M.,2015860196030Fetaih, H.A., A.A. Dessouki and A.S. Tahan,20151 on pregnant rats.]]>3145153Goto, T., D.T. Wicklow and Y. Ito,19966240364038Gupta, R. and V. Sharma,2011Tinospora cordifolia root extract on histopathological and biochemical changes induced by aflatoxin-B1 in mice kidney.]]>189498Hassan, A.M., S.H. Abdel-Aziem, A.A. El-Nekeety and M.A. Abdel-Wahhab,2015Panax ginseng extract modulates oxidative stress, DNA fragmentation and up-regulate gene expression in rats sub chronically treated with aflatoxin B1 and fumonisin B1.]]>67861871Kamdem, L., J. Magdalou, G. Siest, M. Ban and D. Zissu,19831 and ethynylestradiol interaction.]]>672640Marczuk-Krynicka, D., T. Hryniewiecki, J. Piatek and J. Paluszak,20039131135Marvan, F., E. Vernerova, M. Samek, H. Reisnervov, J. Nemec and R. Martakova,19831 residues in the organs of young poultry.]]>248592Mohamed, A.M. and N.S. Metwally,20094116Roebuck, B.D. and Y.Y. Maxuitenko,1994Smela, M.E., S.S. Currier, E.A. Bailey and J.M. Essigmann,20011: From mutational spectrometry to carcinogenesis.]]>22535545Stresser, D.M., G.S. Bailey and D.E. Williams,19941 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat.]]>22383391Yarru, L.P., R.S. Settivari, N.K.S. Gowda, E. Antoniou, D.R. Ledoux and G.E. Rottinghaus,2009Curcuma longa) on the expression of hepatic genes associated with biotransformation, antioxidant and immune systems in broiler chicks fed aflatoxin.]]>8826202627SAS.,20021st Edn.,