Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2016.58.64Sargassum crassifolium]]>HusniAmir PurwantiDwi Ustadi 32016163The objective of this study was to evaluate the potential effect of sodium alginate from Sargassum crassifolium on glucose level and lipid profile in streptozotocin-induced diabetes rats. Sodium alginate extract of S. crassifolium 200, 400 and 600 mg kg1 was administered orally to streptozotocin-induced diabetes rats, once daily for 15 days. The result obtained were then compared with normal control (non-diabetic+normal saline 0.9% p.o), negative control (diabetes+CMC-Na 0.5% p.o) and positive control (diabetic+glibenclamide 5 mg kg1 p.o). The glucose level, lipid profile and body weight were measured on normal condition (baseline) on 0, 5th, 10th, 15th day and pancreatic histopathological study were done on 15th day. Sodium alginate extract of S. crassifolium had yield 23.82% db, viscosity of 521 cps and a water content of 16.18% db. Sodium alginate 600 mg kg1 significantly reduce level preprandial glucose, postprandial glucose and total cholesterol compared negative control and did not have significant difference with positive control. Levels of triglycerides and LDL-c throughout the treatment groups had significant differences with the negative control. Meanwhile, the levels of HDL-c throughout the treatment group did not have significant differences. Necrosis was found in all streptozotocin-induced rats. The higher alginate doses given, getting better lower the levels of glucose and total cholesterol.]]>Draget, K.I., B. Strand, M. Hartmann, S. Valla, O. Smidsrod and G. Skjak-Braek,200027117122El Gamal, A.A.,201018125Firdaus, M., M. Astawan, D. Muchtadi, T. Wresdiyati, S. Waspadji and S.S. Karyono,2010Sargassum echinocarpum extract.]]>193235Gandhi, G.R. and P. Sasikumar,2012Merremia emarginata Burm. F. in streptozotocin induced diabetic rats.]]>2281286Geloneze, B., R.N. Lamounier and O.R. Coelho,200687604613Husni, A., R. Wijayanti and Ustadi,2014Padina pavonica extracts.]]>14515520IDF.,20125th Edn.,Kavishankar, G.B. and N. Lakshmidevi,2014Cucumis prophetarum on streptozotocin-nicotinamide induced type 2 diabetic rats.]]>21624630Kavishankar, G.B., N. Lakshmidevi, S.M. Murthy, H.S. Prakash and S.R. Niranjana,201126580Leiter, L.A., J. Genest, S.B. Harris, G. Lewis and R. McPherson et al.,200630230240Matanjun, P., S. Mohamed, K. Muhammad and N.M. Mustapha,2010Kappaphycus alvarezii, Caulerpa lentillifera and Sargassum polycystum, on high-cholesterol/high-fat diet in rats.]]>13792800Mohamed, S., S.N. Hashim and H. Abdul Rahman,2012238396Moller, D.E.,2001414821827Moree, S.S., G.B. Kavishankar and J. Rajesha,201320237245Noiraksar, T. and T. Ajisaka,2008Sargassum (Phaeophyceae) in the gulf of Thailand.]]>20963977Patel, R., A. Shervington, J.A. Pariente, M.A. Martinez-Burgos, G.M. Salido, E. Adeghate and J. Singh,200610847188Rasyid, A.,2010Sargassum echinocarphum].]]>36393400, (In Indonesian)Tomkin, G.H.,200831S241S248WHO.,19851985WHO.,1999pp: 1-58pp: 1-58Yavorska, N.,201266669