Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2014.20.37MansourianAzad Reza12014141The definition of non-thyroidal illness arises from the fact that thyroid hormones
within blood circulation is reduced not due to the malfunction of thyroid organ,
but it is mamifested from disorders of other organs. Clinical conditions such
as cardiovascular diseases mainly myocardial infraction, sepsis, surgery and many
other chronic and sever diseases are associated with thyroid hormones reduction.
Serum T3 concentration is reduced during non-thyroidal illness, but serum T4 concentration
is seemed to be raised in most of the cases, which is due to the inhibition of
T4 conversion into T3 as result of reduced activity of deidoniase enzyme. It seems
the reduction in the T3 concentration do not exhibit neither any negative side
effects in metabolism nor any irreversible harm in patient involved. There is
not any suggestion that hypothyroidism originated from non-thyroidal illness can
be rapidly leads to fatal outcome but such low reduction in thyrod hormones and
particularly T3 can be considered as a key factor for the initiating the medical
attendance and the necessary steps to prevent further clinical complication.]]>Abozenah, H., S. Shoeb, A. Sabry and H. Ismail,200821623Acker, C.G., A.R. Singh, R.P. Flick, J. Bernardini, A. Greenberg and J.P. Johnson,200057293298Acker, C.G., R. Flick, R. Shapiro, V.P. Scantlebury and M.L. Jordan et al.,200225761Arem, R., G.J. Wiener, S.G. Kaplan, H.S. Kim, S. Reichlin and M.M. Kaplan,19934211021108Afandi, B., G.C. Schussler, A.H. Arafeh, A. Boutros, M.G. Yap and A. Finkelstein,200049270274Arem, R. and S. Deppe,199088258262Boelen, A., M.C. Platvoet-ter Schiphorst and W.M. Wiersinga,1997153115122Bartalena, L., S. Brogioni, L. Grasso, F. Velluzzi and E. Martino,199417269274Boelen, A., M.C. Platvoet-Ter Schiphorst and W.M. Wiersinga,19937716951699Boelen, A., M.C. Schiphorst and W.M. Wiersinga,199619480483Brent, G.A. and J.M. Hershman,19866318Boelen, A., M.C. Platvoet-Ter Schiphorst and W.M. Wiersinga,199580971976Burman, K.D., L. Wartofsky, R.E. Dinterman, P. Kesler and R.W. 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