Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2013.123.130Sesbania sesban L.(Merr) On Acute And Chronic Inflammation in Experimental Induced Animals]]>TatiyaAnil U. DandePayal R. MuthaRakesh E. SuranaSanjay J. 32013133Sesbania sesban L. Merr (Leguminosae) is an important medicinal plant in India, used by indigenous people to relieve rheumatic pains. The anti-inflammatory activity of Sesbania sesban L. Merr. (Leguminosae) crude saponin (SAP) was investigated for the first time. The SAP was tested for the presence of triterpenoid and steroids. The diosgenin and oleanolic acid were isolated from saponin fraction and characterized by using HPTLC and GC-MS. The anti-inflammatory activity of crude saponin was studied by in vivo animal models like carrageenan and histamine induced rat paw edema, cotton pellet granuloma, acetic acid induced vascular permeability and oxazolone induced delayed type hypersensitivity. Mechanism action of inflammation was also observed by in vitro heat induced haemolysis and inhibition of protein denaturation assay. The crude saponin (SAP) extract showed significant activity in the in vivo and in vitro model at the dose of 500 mg kg-1 body weight orally, when compared to control and standard drug. These findings showed that the crude saponin contains triterpenoid and steroidal moiety which may be contributes to the observed anti-inflammatory activity.]]>Anonymous,1958pp: 293-302pp: 293-302Bhaduri, B., C.R. Ghosh, A.N. Bose, B.K. Moza and B.P. Basu,19686252253Chatterjee, S. and S.N. Das,199628116119D'Arcy, P.F., E.M. Howard, P.W. Muggleton and S.B. Townsend,196012659665Dingle, T.J.,196179509512Dorsaz, A.C., M. Hostettmann and K. Hostettmann,1988Sesbania sesban.]]>54225257Fang, Q.M., H. Zhang, Y. Cao and C. Wang,20071146165Giner-Larza, E.M., S. Manez, M.C. Recio, R.M. Giner, J.M. Prieto, M. Cerda-Nicolas and J.L. Rios,2001Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.]]>428137143Wang, J.R. H. Zhou, Z.H. Jiang, Y.F. Wong and L. Liu,2008In vivo anti-inflammatory and analgesic activities of a purified saponin fraction derived from the root of Ilex pubescens.]]>31643643Kaskiw, M.J., M.L. Tassotto, J. Th'ng and Z.H. Jiang,20081632093217Khare, C.P.,20042004pp: 423pp: 423Kim, K.A., J.S. Lee, H.J. Park, J.W. Kim and C.J. Kim et al.,20047427692779Kirtikar, K.R. and B.D. Basu,19962nd Edn.,Pages: 733Pages: 733Kou, J., M. Si, G. Dai, Y. Lin and D. Zhu,2006Polygala japonica extract.]]>77411415Mazumder, U.K., M. Gupta, L. Manikandan, S. Bhattacharya, P.K. Haldar and S. Roy,2003Vernonia cinerea Less. extract in rats.]]>10185188Miller, LC. and M.L. Tainter,194450 and its error means of logarithmic probit graph paper.]]>57261264Mohammad, A.,2005pp: 345-447, 472-529pp: 345-447, 472-529Moodley, I., Y. Sotsios and B. Bertin,19954112116Okoli, C.O. and P.A. Akah,2004Culcasia scandens P. Beauv (Araceae).]]>79473481Olajide, O.A., S.O. Awe, J.M. Mikinde, A.I. Ekhler, A. Olusola, O. Morebise and D.T. Okpako, 2000Alstonia boonei stem bark.]]>71179186Rajpal, V.,20021st Edn.,Sasikumar, J.M., M. Palniswamy, A. Doss, P.A. Doss and V. Geetha,2005Sesbania aegyptiaca Pers. leaves.]]>11765767Saso, L., G. Valentin, M.L. Casini, E. Grippa, M.T. Gatto, M.G. Leone and B. Silvestrini,200124150158Shen, T.Y.,1967pp: 1-29pp: 1-29Shinde, U.A., A.S. Phadke, A.M. Nair, A.A. Mungantiwar, V.J. Dikshit and M.N. Saraf,1999Cedrus deodara wood oil.]]>70251257Spector, W.G. and D.A. Willoughby,1998Pages: 815Pages: 815Haraguchi, M., Y. Mimaki, M.M. Braggio, W.O. Santiago, A. Yokosuka and Y. Sashida,2000Sesbania sesban.]]>54350350Trease, G.E. and W.C. Evans,198913th Edn.,pp: 582-591pp: 582-591Varshney, I.P., M.O. Farooq and S.Y. Khan,1959Sesbania aegyptiaca Pers.]]>48466468Vogel, H.G. and W.H. Vogel,1997pp: 696-716pp: 696-716Whittle, B.A.,196422246253Winter, C.A., E.A. Risley and G.W. Nuss,1962111544547