Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2012.385.392Nephelium lappaceum Rind Extract against Collagen-induced Arthritis in Dark Agouti Rats]]>KumarShashi ChakravarthiSrikumar ChiewGan Seng SubramaniamThavamanithevi PalanisamyUmadevi RadhakrishnanAmmu HaleagraharaNagaraja 72012127Pathogenic mechanisms of arthritis are studied using Collagen-Induced
Arthritis (CIA) animal models. Plant derived antioxidants are known to reduce
the inflammatory response in CIA. The aim of the study was to assess the protective
efficacy of Nephelium lappaceum ethanol extract against Collagen-Induced
Arthritis (CIA) in dark agouti rats. Arthritis was induced with 4 mg kg-1
of collagen in complete Freund's adjuvant. CIA rats were orally treated with
100 and 200 mg kg-1 per oral of N. lappaceum from day 25-50.
Changes in body weight, joint thickness, C-reactive protein were recorded and
immunohistochemistry for matrix metalloproteinase-13 (MMP-13) and tissue inhibitor
of matrix metalloproteinase-1 (TIMP-1) was done. N. lappaceum (100 and
200 mg kg-1) significantly reduced (p<0.05) the arthritis-induced
changes in body weight and paw edema. There was a significant reduction (p<0.05)
in the C-reactive protein in the treatment groups. A significant reduction (p<0.05)
in the arthritis-induced histopathological changes was seen after treatment
with N. lappaceum. Treatment with N. lappaceum showed dose dependent
effects on MMP-13 and TIMP-1 levels. N. lappaceum rind extract significantly
suppressed the physiological, biochemical and histopathological changes produced
during collagen-induced arthritis in dark Agouti rats. N. lappaceum extract
supplementation may be beneficial in preventing the tissue damage and inflammatory
conditions in arthritis.]]>Asquith, D.L., A.M. Miller, I.B. McInnes and F.Y. Liew,20093920402044Brand, D.D., K.A. Latham and E.F. Rosloniec,2007212691275Buchanan, H.M., S.J. Preston, P.M. Brooks and W.W. Buchanan,199130125134Choy, E.H.S. and G.S. Panayi,2001Rheumatoid arthritis.]]>344907916Dembitsky, V.M., S. Poovarodom, H. Leontowicz, M. Leontowicz, S. Vearasilp, S. Trakhtenberg and S. Gorinstein,20114416711701Hagfors, L., P. Leanderson, L. Skoldstam, J. Andersson and G. Johansson,20032003Halliwell, B., J.R. Hoult and D.R. Blake,1988228672873Jones, N.R., M.A. Pegues, M.A. McCrory, S.W. Kerr and H. Jiang et al.,20116326412650Kumar, N., S. Singh, N. Patro and I. Patro,2009Spirulina platensis against collagen-induced arthritis in rats.]]>17181190Lee, D.M. and M.E. Weinblatt,2001358903911Mahajan, A. and V.R. Tandon,200412139142Mangge, H., J. Hermann and K. Schauenstein,199928201209Martinez-Castellanos, G., K. Shirai, C. Pelayo-Zaldivar, L.J. Perez-Flores and J.D. Sepulveda-Sanchez,2009Nephelium lappaceum).]]>26444449McInnes, I.B. and G. Schett,20077429442Nagatomo, F., N. Gu, H. Fujino, T. Okiura, F. Morimatsu, I. Takeda and A. Ishihara,201010713Navarro-Cano, G., I. del Rincon, S. Pogosian, J.F. Roldan and A. Escalante,20034824252433Palanisamy, U., H.M. Cheng, T. Masilamani, T. Subramaniam, L.T. Ling and A.K. Radhakrishnan,2008Nephelium lappaceum, a potential source of natural antioxidants.]]>1095463Palanisamy, U.D., L.T. Ling, T. Manaharan and D. Appleton,2011Nephelium lappaceum rind waste and its anti-hyperglycemic activity.]]>1272127Panush, R.S.,199117259272Poole, C.D., P. Conway, A. Reynolds and C.J. Currie,20082008Rhodes, B., B.G. Furnrohra nd T.J. Vyse,20117282289Sato, M., T. Miyazaki, T. Nagaya, Y. Murata, N. Ida, K. Maeda and H. Seo, 199623432438Shukla, M., K. Gupta, Z. Rasheed, K.A. Khan and T.M. Haqqi,200824733743Thitilertdecha, N., A. Teerawutgulrag, J.D. Kilburn and N. Rakariyatham,2010Nephelium lappaceum L. and their antioxidant activities.]]>1514531465Thitilertdecha, N., A. Teerawutgulrag and N. Rakariyatham,2008Nephelium lappaceum L. extracts.]]>4120292035Trentham, D.E., A.S. Townes and A.H. Kang,1977146857868Tudave, D., A. Radhakrishnan, S. Chakravathi and N. Haleagrahara,201160897907Uchida, M., M. Shima, T. Shimoaka, A. Fujieda and K. Obara et al.,2000185207214Holmdahl, R.,199542104109Lee, K.H., Y.S. Chen, J.P. Judson, S. Chakravarthi, Y.M. Sim and H.M. Er,2008Euphorbia hirta on cartilage degeneration in arthritic rats.]]>3095102Van den Berg, W.B.,20092009