Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2010.373.385GoharAli Vaziri 52010105The best characterized of epigenetic is the modifications that occur on DNA and histones that can specify regulate transcriptional activity. Since discovery of cancer epigenetic in 1983, there is an explosion of interest in the epigenetic of cancer study. The epigenetic of cancer has been associated with all stages of tumor formation and progression. DNA methylation and histone acetylation are important epigenetic mechanisms of gene regulation and play essential roles in tumor initiation and progression. Also, epigenetic alterations are potentially reversible, but epigenetic events can facilitate genetic damage by the increased mutagenicity of 5-methylcytosine by DNA methylation. The advantages of epigenetic changes can be used as powerful marker to detect cancer cells or cancer-derived and have made the way of innovative diagnostic and therapeutic strategies, although only a few genes have given promising results as potential tumor biomarkers.]]>Ahrendt, S.A., J.T. Chow, L.H. Xu, S.C. Yang and C.F. Eisenberger et al.,199991332339Antequera, F. and A. Bird,19999R661667Banwell, C.M., R. Singh, P.M. Stewart, M.R. Uskokovic and M.J. Campbell,20031648398Bartling, B., H.S. Hofmann, T. Boettger, G. Hansen, S. Burdach, R.E. Silber and A. Simm,200549145154Battagli, C., R.G. Uzzo, E. Dulaimi, I.I. de Caceres and R. Krassenstein et al.,20036386958699Baylin, S.B., M. Makos, J.J. Wu, R.W. Yen and A. De Bustros et al.,19913383390Baylin, S.B., S.A. Belinsky and J.G. Herman,20009214601461Belinsky, S.A., D.M. Klinge, C.A. Stidley, J.P. Issa, J.G. Herman, T.H. March and S.B. Baylin,20036370897093Belinsky, S.A., K.J. Nikula, W.A. Palmisano, R. Michels and G. Saccomanno et al.,1998951189111896Belinsky, S.A., W.A. Palmisano, F.D. Gilliland, L.A. Crooks and K.K. Divine et al.,20016223702377Bird, A.P.,1986321209213Blaheta, R.A., M. Michaelis, P.H. Driever and J. Cinatl,200525383397Brueckner, B., R.G. Boy, P. Siedlecki, T. Musch and H.C. Kliem et al.,20056563056311Burkitt, K. and M. Ljungman,200872424Butler, L.M., Y. Webb, D. B. Agus, B. Higgins and T.R. Tolentino et al.,20017962970Cairn, P., M. Esteller, J.G. Herman, M. Schoenberg and C. Jeronimo et al.,2001727272730Camacho, L.H., J. Olson, W.P. Tong, C.W. Young, D.R. Spriggs and M.G. Malkin,200725131138Cameron, E.E., K.E. Bachman, S. Myohanen, J.G. Herman and S.B. Baylin,199921103107Camphausen, K., T. Scott, M. Sproull and P.J. Tofilon,20041060666071Cao, R., L. Wang, H. Wang, L. Xia and H. Erdjument-Bromage et al.,200229810391043Chan, M.W., L.W. Chan, N.L. Tang, J.H. Tong and K.W. Lo et al.,20028464470Chuang, J.C., C.B. Yoo, J.M. Kwan, T.W. Li, G. Liang, A.S. Yang and P.A. Jones,2005415151520Cinatl, J., R. Kotchetkov, R. Blaheta, P.H. Driever, J.U. Vogel and J. Cinatl,20022097106Cormier, R.T. and W.F. Dove,20006039653970Costello, J.F., C. Plass and W.K. Cavenee,2000174956Cravo, M., R. Pinto, P. Fidalgo, P. Chaves and L. Gloria et al.,199639434438Cui, H., I.L. Horon, R. Ohlsson, S.R. Hamilton and A.P. Feinberg,1998412761280Cui, H., M. Cruz-Correa, F.M. Giardiello, D.F. Hutcheon and D.R. Kafonek et al.,200329917531755Dulaimi, E., R.G. Uzzo, R.E. Greenberg, T. Al-Saleem and P. Cairns,20041018871893Dunn, B.K.,20039832842Dyer, E.S., M.T. Paulsen, S.M. Markwart, M. Goh, D.L. Livant and M. Ljungman,2002101496499Ehrlich, M.,20022154005413El-Osta, A.,20032510711084Esteller, M., J. Garcia-Foncillas, E. Andion, S.N. Goodman and O.F. Hidalgo et al.,200034313501354Esteller, M., J.M. Silva, G. Dominguez, F. Bonilla and Xavier Matias-Guiu et al.,200092564569Evron, E., W.C. Dooley, C.B. Umbricht, D. Rosenthal and N. Sacchi et al.,200135713351336Fang, M.Z., Y. Wang, N. Ai, Z. Hou and Y. Sun et al.,20036375637570Feinberg, A.P. and B. Tycko,20044143153Feinberg, A.P., C.W. Gehrke, K.C Kuo and M. Ehrlich,19884811591161Fischle, W., Y. Wang and C.D. Allis,2003425475479Fruhwald, M.C. and C. Plass,200275116Fuks, F., P.J. Hurd, D. Wolf, X. Nan, A.P. Bird and T. Kouzarides,200327840354040Gardiner-Garden, M. and M. Frommer,1987196261282Gaudet, F., J.G. Hodgson, A. Eden, L. Jackson-Grusby and J. Dausman et al.,2003300489492Ghoshal, K., J. Datta, S. Majumder, S. Bai and X. Dong et al.,20022283028319Ghoshal, K. and S. Bai,200743395422Glaser, K.B.,200774659671Goessl, C., H. Krause, M. Muller, R. Heicappell and M. Schrader et al.,20006059415945Goffin, J. and E. Eisenhauer,20021316991716Goldsmith, M.E., M. Kitazono, P. Fok, T. Aikou, S. Bates and T. Fojo,2003953945401Gore, S.D., L.J. Weng, W.D. Figg, S. Zhai and R.C. Donehower et al.,20028963970Gore, S.D., S. Baylin, E. Sugar, H. Carraway and C.B. Miller et al.,20066663616369Gray, S.G. and T.J. Ekstrom,20012627583Gronbaek, K., C. Hother and P.A. Jones,200711510391059Hagihara, A., K. Miyamoto, J. Furuta, N. Hiraoka and K. Wakazono et al.,20042387058710Halkidou, K., L. Gaughan, S. Cook, H.Y. Leung, D.E. Neal and C.N. Robson,200459177189Hebbes, T.R., A.W. Thorne, A.L. Clayton and C. Crane-Robinson,19922010171022Herman, J.G. and S.B. Baylin,200334920422054Herman, J.G., J.R. Graff, S. Myohanen, B.D. Nelkin and S.B. Baylin,19969398219826Hibi, K., M. Taguchi, H. Nakayama, T. Takase and Y. Kasai et al.,2001731353138Huang, H., C.P. Reed, J.S. Zhang, V. Shridhar, L. Wang and D.I. Smith,19995929812988Ikeda, N., H. Uemura, H. Ishiguro, M. Hori and M. Hosaka et al.,20032739746Issa, J.P., G. Garcia-Manero, F.J. Giles, R. Mannari and D. Thomas et al.,200410316351640Jackson-Grusby, L., P.W. Laird, S.N. Magge, B.J. Moeller and R. Jaenisch,19979446814685Jaenisch, R. and A. Bird,200333245254Jenuwein, T. and C.D. Allis,200129310741080Johnstone, R.W.,20021287299Jones, P.A. and S.B. Baylin,20023415428Jones, P.A. and S.M. Taylor,1980208593Jones, P.A. and S.B. Baylin,2007128683692Kaneda, A., M. Kaminishi, K. Yanagihara, T. Sugimura and T. Ushijima,20026266456650Kantarjian, H.M., S. O'Brien, J. Shan, A. Aribi and G. Garcia-Manero et al.,2007109265273Kawakami, K., J. Brabender, R.V. Lord, S. Groshen and B.D. Greenwald et al.,20009218051811Kersting, M., C. Friedl, A. Kraus, M. Behn, W. Pankow and M. Schuermann,20001832213229Kim, M.S., M. Blake, J.H. Baek, G. Kohlhagen, Y. Pommier and F. Carrier,20036372917300Kingston, R.E., C.A. Bunker and A.N. Imbalzano,199610905920Kleer, C.G., Q. Cao, S. Varambally, R. Shen and I. Ota et al.,20031001160611611Klisovic, R.B., W. Stock, S. Cataland, M.I. Klisovic and S. Liu et al.,20081424442449Kouraklis, G. and S. Theocharis,200615489494Kouzarides, T.,2007128693705Krassenstein, R., E. Sauter, E. Dulaimi, C. Battagli and H. Ehya et al.,2004102832Krivtsov, A.V. and S.A. Armstrong,20077823833Lai, M.T., C.C. Yang, T.Y. Lin, F.J. Tsai and W.C. Chen,200826182189Laird, C.D., N.D. Pleasant, A.D. Clark, J.L. Sneeden and K.M. Hassan et al.,2004101204209Laird, P.W.,20033253266Laird, P., L. Jackson-Grusby, A. Fazeli, S. Dickinson, W. Jung, R. Weinberg and R. Jaenisch,199581197205Langer, F., J. Dingemann, H. Kreipe and U. Lehmann,200529325329Lau, K.M., M. LaSpina, J. Long and S.M. Ho,20006031753182Lengauer, C.,2003300442443Li, E.,20023662673Liang, G., M.F. Chan, Y. Tomigahara, Y.C. Tsai and F.A. Gonzales et al.,200222480491Lin, X., K. Asgari, M.J. Putzi, W.R. Gage and X. Yu et al.,20016186118616Marks, P.A., V.M. Richon and R.A. Rifkind,20009212101216Marks, P.A., V.M. Richon, T. Miller, W.K. Kelly,200491137168Marquez, V.E., J.J. Barchi, J.A. Kelley, K.V. Rao and R. Agbaria et al.,200524305318Miyamoto, K., K. Asada, T. Fukutomi, E. Okochi and Y. Yagi et al.,200322274280Moffatt, K.A., W.U. Johannes and G.J. Miller,19995695703Momparler, R.L.,200532443451Muller, H.M., M. Oberwalder, H. Fiegl, M. Morandell and G. Goebel et al.,200436312831285Nguyen, C.T., D.J. Weisenberger, M. Velicescu, F.A. Gonzales and J.C. Lin et al.,20026264566461Nishigaki, M., K. Aoyagi, I. Danjoh, M. Fukaya and K. Yanagihara et al.,20056521152124Okano, M., D.W. Bell, D.A. Haber and E. Li,199999247257Okochi-Takada, E., S. Ichimura, A. Kaneda, T. Sugimura and T. Ushijima,2004568187194Olsen, E.A., Y.H. Kim, T.M. Kuzel, T.R. Pacheco and F.M. Foss et al.,20072531093115Palmisano, W.A., K.K. Divine, G. Saccomanno, F.D. Gilliland and S.B. Baylin et al.,20006059545958Pan, L., A.F. Matloob, J. Du, H. Pan and Z. Donget al.,2010277989999Patra, S.K., A. Patra, H. Zhao and R. Dahiya,200233163171Pauer, L.R., J. Olivares, C. Cunningham, A. Williams and W. Grove et al.,200422886896Pong, R.C., Y.J. Lai, H. Chen, T. Okegawa and E. Frenkel et al.,20036386808686Pradhan, S., A. Bacolla, R.D. Wells and R.J. Roberts,19992743300233010Prakash, S., B.J. Foster, M. Meyer, A. Wozniak and L.K. Heilbrun et al.,200119111Qian, D.Z., Y.F. Wei, X. Wang, Y. Kato, L. Cheng and R. Pili,20076711821193Ransohoff, D.F.,200329916791680Ricciardiello, L., A. Goel, V. Mantovani, T. Fiorini and S. Fossi et al.,200363787792Robertson, K.D.,20012031393155Rosas, S.L., W. Koch, M.G. da Costa Carvalho, L. Wu and J. Califano et al.,200161939942Sakatani, T., A. Kaneda, C.A. Iacobuzio-Donahue, M.G. Carter and S. de Boom Witzel, et al.,200530719761978Sakuma, T., K. Uzawa, T. Onda, M. Shiiba, H. Yokoe, T. Shibahara and H. Tanzawa,200629117124Santos-Rosa, H. and C. Caldas,20054123812402Sasakawa, Y., Y. Naoe, T. Noto, T. Inoue and T. Sasakawa et al.,200366897906Scheinbart, L.S., M.A. Johnson, L.A. Gross, S.R. Edelstein and B.C. Richardson,199118530534Silverman, L.R., E.P. Demakos, B.L. Peterson, A.B. Kornblith and J.C. Holland et al.,20022024292440Song, J., J.H. Noh, J.H. Lee, J.W. Eun and Y.M. Ahn et al.,2005113264268Soria, J.C., M. Rodriguez, D.D. Liu and J.J. Lee et al.,200262351355Stearns, V., Q. Zhou and N.E. Davidson,200725659665Steele, N.L., J.A. Plumb, L. Vidal, J. Tjornelund and P. Knoblauch et al.,200814804810Stewart, D.J., R.C. Donehower, E.A. Eisenhauer, N. Wainman and A.K. Shah et al.,200314766774Stirzaker, C., J.Z. Song, B. Davidson and S.J. Clark,20046438713877Suenaga, M., H. Soda, M. Oka, A. Yamaguchi and K. Nakatomi et al.,200297621625Tao, L., S. Yang, M. Xie, P.M. Kramer and M.A. Pereira,2000158185193Thelen, P., S. Schweyer, B. Hemmerlein, W. Wuttke, F. Seseke and R.H. Ringert,2004242531 Thibault, A., W.D. Figg, R.C. Bergan, R.M. Lush and C.E. Myers et al.,1998848789Tonini, T., G. D'Andrilli, A. Fucito, L. Gaspa and L. Bagella,2008214295300Tsubaki, J., V. Hwa, S.M. Twigg and R.G. Rosenfeld,200214317781788Tsujiuchi, T., M. Tsutsumi, Y. Sasaki, M. Takahama and Y. Konishi,199990909913Turner, B.M.,19937558Urnov, F.D.,20021322450S2456SUshijima, T., N. Watanabe, E. Okochi, A. Kaneda, T. Sugimura and K. Miyamoto,200313868874Van Leenders, G.J., D. Dukers, D. Hessels, S.W. Van den Kieboom and C.A. Hulsbergen et al.,200752455463Van Veldhuizen, P.J., R. Sadasivan, R. Cherian and A. Wyatt,1996312811Gohar, A.V. and A. Mohammadi,201010200208Vaziri Gohar, A., A. Mohammadi and M. Heidari,2007Villar-Garea, A., M.F. Fraga, J. Espada and M. Esteller,20036349844989Visser, H.P., M.J. Gunster, H.C. Kluin-Nelemans, E.M. Manders and F.M. Raaphorst et al.,2001112950958Weiser, T.S., Z.S. Guo, G.A. Ohnmacht, M.L. Parkhurst and P. Tong-On et al.,200124151161Wilson, C.A., L. Ramos, M.R. Villasenor, K.H. Anders and M.F. Press et al.,199921236240Winquist, E., J. Knox, J.P. Ayoub, L. Wood and N. Wainman et al.,200624159167Wolffe, A.P. and M.A. Matzke,1999286481486Woodson, K., A. Flood, L. Green, J.A. Tangrea and J. Hanson et al.,200496407410Wu, L.P., X. Wang, L. Li, Y. Zhao and S. Lu et al.,20082832193235Xu, W.S., R.B. Parmigiani and P.A. Marks,20072655415552Tada, Y., M. Wada, K. Taguchi, Y. Mochida and N. Kinugawa et al.,20026240484053Yang, A.S., M.R. Estecio, G. Garcia-Manero, H.M. Kantarjian and J.P. Issa,200330211531153Yang, E.S. and K.L. Burnstein,20032784686246868Yao, X., J.F. Hu, M. Daniels, H. Shiran and X. Zhou et al.,2003111265273Yegnasubramanian, S., J. Kowalski, M.L. Gonzalgo, M. Zahurak and S. Piantadosi et al.,20046419751986Yoo, C.B., J.C. Chuang, H. Byun, G. Egger and A.S. Yang et al.,20084233240Yoo, C.B. and P.A. Jones,200653750Yoshida, M., R. Furumai, M. Nishiyama, Y. Komatsu, N. Nishino and S. Horinouchi,200148S20S26Zhang, Y. and D. Reinberg,20011523432360Zhao, X.Y., D.M. Peehl, N.M. Navone and D. Feldman,200014125482556Zheng, Y.G., J. Wu, Z. Chen and M. Goodman,200828645687