Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2009.381.384Khaksary MahabadyM. Najafzadeh VarziH. 4200994In this study, the prophylactic effects of vitamin E and silymarin
on teratogenic effects of phenytoin was compared. This study was performed on
32 pregnant rats that were divided into four groups. The first group (control
group) received normal saline intraperitonealy and the other groups (test groups)
received phenytoin (75 mg kg-1 b.wt.) intraperitonealy) at 10-11th
day of gestation. Vitamin E and silymarin were administrated at dose of 100
mg kg-1 b.wt. intraperitonealy, respectively, in along with, in two
groups. Fetuses were carried out in 20th day of gestation and after determination
of weight and length; they were stained by Alizarin Red-Alcian Blue method.
Cleft palate incidence was 16.66, 5.55 and 2.77% in fetuses of rats that received
only phenytoin, phenytoin with silymarin and phenytoin with vitamin E, respectively.
Mean weight and length of fetuses of animals that received normal saline was
significantly greater than those received vitamin E and silymarin. It is concluded
that vitamin E can decrease oxidative stress more than silymarin and has better
prophylactic effect on incidence of phenytoin- induced cleft palate.]]>Boskovic, R., L. Gargaun, D. Oren, J. Djulus and G. Koren,20052048485Brogaard, B. and J. Clausen,1997in vitro system for evaluation of oxidative stress and effects of antioxidants.]]>25279287Capper, J.L., R.G. Wilkinson, E. Kasapidou, S.E. Pattison, A.M. Mackenzie and L.A. Sinclair,200593549557Cohen â€`Kerem, R. and G. Koren,20032519 Danielsson, B.R., F. Azarbayjani, A.C. Skold and W.S. Webster,199756271281De Santis, M., G. Straface, B. Carducci, A.F. Cavaliere, L. De santis, A. Lu echese, A.M. Merola and A. Caruso,20041171019Finnell, R.H.,1999103337342 Giavini, E. and E. Menegola,2004857381Kappus, H. and A.T. Diplock,1992135574Kimmel, C.A. and C. Trammel,198156271273Oliveira, C., F.P. Lopasso, F. Laurindo, R.M. Leitao and A.A. Laundanna,20013330103014Orup, H.J.R., L.B. Holmes, D.A. Keith and B.A. Coull,20036219Prater, M.R., K.L. Zimmerman, D. Lee Ward and S.D. Holladay,200470862869Syska, E., R. Schmidt and J. Schubert,20043224Viana, M., E. Herrera and B. Bonet,19963910411061Wells, P.G., P.M. Kim, R.R. Laposa, C.J. Nicol, T. Parman and L.M. Winn,19973966578Wells, P.G. and L.M. Winn,199631140Winn, L.M. and P.G. Wells,199622607621Winn, L.M. and P.G. Wells,199926266274Zhu, M.X. and S.S. Zhou,198930246251