Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2009.333.338RezaieA. TavasoliA. BahonarA. MehrazmaM. 4200994Objectives of this study were to describe classification and grading in canine mammary carcinoma. The histological diagnosis was made on the basis of the current WHO classification for canine mammary tumors and then tumors were graded histologically in accordance with the Elston and Ellis method for human breast tumors and based on the assessment of three morphological features: tubule formation, nuclear pleomorphism and mitotic counts. The mammary carcinomas of 33 cases were classified to 17 (51.5%) simple carcinoma, 12 (36.4%) complex carcinoma and 4 (12.1%) carcinoma arising in benign tumor. The histological grade of these cases were as follows: grade I, 11 (33.3%); grade II, 7 (21.2%); Grade III, 15 (45.5%). Present results illustrated good relationship between tumors grading and histological type also revealed that most grade II and III of these tumors were classified as simple one. Despite of many methods for grading such as Gilbertson and Misdorp method used in this research was less complicated and more comparable with human medicine. So, this routine use of this method would help the pathologist and clinician for more accurate prognosis and treatment in canine mammary carcinoma and facilitate comparative studies of canine and human researches.]]>Antuofermo, E., M.A. Miller, S. Pirino, J. Xie, S. Badve and S.I. Mohammed,20071622472256Benjamin, S.A., A.C. Lee and W.J. Saunders,199936423436Cadieu, E. and E.A. Ostrander,20071621812183Castagnaro, M., C. Casalone, E. Bozzetta, R. De Maria, B. Biolatti and M. Caramelli,1998119263275Dutra, A.P., N.V.M. Granja, F.C. Schmitt and G.D. Cassali,20043716731681Elston, C.W., G.A. Gresham, G.S. Rao, T. Zebro, J.L. Haybittle and J. Houghton,198245655669Elston, C.W. and I.O. Ellis,199119403410Elston, C.W. and I.O. Ellis,19981998pp: 365-384pp: 365-384Elston, C.W. and I.O. Ellis,199119403410Gama, A., J. Paredes, F. Albergaria and F. Schmitt,20041301320Gartner, F., M. Geraldes, G. Cassali, A. Rema and F. Schmitt,19991583947Gilbertson, S.R., I.D. Kurzman, R.E. Zachrau, A.I. Hurvitz and M.M. Black,198320127142Karayannopoulou, M., E. Kaldrymidou, T.C. Constantinidis and A. Dessiris,2005133246252Martin De Las Mulas, J., Y. Millan and R. Dios,200542200212Millanta, F., G. Lazzeri, I. Vannozzi, P. Viacava and A. Poli,200239690696Misdorp, W., R.W. Else, E. Hellmen and T.P. Lipscomb,19992nd Edn.,Misdorp, W.,20022002Munson, L. and A. Moresco,200728712Nieto, A., M.D. Perez-Alenza and N.D. Castillo,2003128260268Pena, L.L., A.I. Nieto, D. Rerez-Alenza, P. Cuesta and M. Castano,199810237246Pena, L., M.D. Perez-Alenza, A. Rodriguez-Bertos and A. Nieto,200378141148Preziosi, R., G. Sarli, C. Benazzi and P.S. Marcato,1995113301313Restucci, B., G. De Vico and P. Maiolino,200037297301Sarli, G., R. Preziosi, C. Benazzi, G. Castellani and P.S. Marcato,2002142534