Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2008.940.944MaryamTehranipour 5200885Structural brain abnormalities are more frequent in
diabetes. Cerebrospinal fluid (CSF) is vital in controlling development
of the nervous system along the whole length of the neural tube and the
externalization of CSF during development is essential for the formation
of the layers of neurons in the cerebral cortex. Previous studies have
shown diabetes change CSF composition. In this study, we investigated
the effect of maternal diabetes on lateral ventricle volume in developmental
stages (embryonic, neonatal and adulthood). Diabetes was induced in female
Wistar rats by intraperitoneal injection of STZ (55 mg kg-1
in citrate buffer, confirmed by glucose analysis: 100 ±5 mg dL-1
control, 470 ±18 mg dL-1 diabetic rats). At the 15, 1
and 30 day after birth, embryos and infants were anesthetized, brain were
rapidly removed and fixed. Paraffin embedded tissue blocks were sectioned
serially and stained with H.E. Then the volume of the lateral ventricle
were measured with stereological methods. Results show in all stage of
developing diabetic groups had significantly larger ventricle volume than
controls (p<0.01). Therefore pregnant women who suffer from diabetes
more likely to have a child with central nervous system problems, according
to a new study.]]>Arvanitakis, Z., R.S. Wilson, J.L. Bienias, D.A. Evans and D.A. Bennett,200461661666Banks, W.A.,2006291H2595H2596Brown, P.D., S.L. Davies, T. Speake and I.D. Millar,2004129957970Doublier, S., C. Duyckaerts, D. Seurin and M.O. Binoux, 200010267274Egleton, R.D., C. Campos, J. Huber, R. Brown and T. Davis,20035214961501Flanagan, M.,2002202641Gundersen, H.J.G., T.F. Bendtsen, L. Korbo, N. Marcussen and A. Moller et al.,198896379394Jarvis, J.P., H.J. Kenney, T.H. Ehrich, L.S. Pletscher, C.F. Semenkovich and J.M. Cheverud,20054616921702Malcolm B.S.,200020183196Miyan, J., M. Nabiyouni and M. Zendah,200381317328Nabiyouni, M., C. Storey, J. Owen and J. Miyan,20041529529Last, D., D.C. Alsop, A.M. Abduljalil, R.P. Marquis and C. De Bazelaire et al.,20073011931199Pérez-Fígares, J.M., A.J. Jimenez and E.M. Rodríguez, 200152591607Quarantelli, M., A. Ciarmiello, V.B. Morra, G. Orefice and M. Larobina et al.,200318360366Ristow, M.,200482510529Calvo, R., G. Morreale de Escobar, F. Escobar del Rey and M.J. Obregon,199713811591169Spijkeman, A.M. and J.M. Dekker,20032626042608Tarnaris, A., L.D. Watkins and N.D. Kitchen,200641111Tehranipour, M., H.R. Ali, B.R. Morteza, P. Kazem and R. Amin,20077969972De Wit, O.A., W.F.A. den Dunnen, K.M. Sollie, R.I. Munoz and L.C. Meiners et al.,20082008