Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2008.789.793HanachiP. GolkhoS. 4200884The purpose of this study was to determine the effect
of soy phytoestrogens and exercise on lipid profiles and menopausal symptoms
in menopausal women. In this study, 37 postmenopausal women (mean age
= 52.2 ± 4.6 years) were randomly assigned to soymilk (n = 15),
exercise+soymilk (n = 12) and control (n = 10) which were provided daily
for 3 months. Subjects were given soymilk (Maxsoy, Co.) which contained
12.5 g of soy protein with Genistein, 13 mg and Daidzein, 4.13 mg day-1.
Menopausal symptoms was measured using the Kupperman index, a standard
measure of climacteric symptoms that has been validated in menopausal
women at baseline and 3 months of daily use. Total Antioxidant Status
(TAS) of serum was measured using the Ferric Reducing Ability of Plasma
(FRAP) assay. Soymilk supplementation, Soymilk and moderate exercise significantly
(p<0.05) improved TAC level. Vasomotor symptoms were improved (p<0.05)
in soymilk consumption and moderate exercise and soymilk groups compared
with control group. Vaginal problem, sexual symptoms and vasomotor significantly
reduced (p<0.05) after soymilk consumption. The soymilk treatment and
exercise+soymilk decreased total cholesterol and triglyceride levels compared
with control group. This study suggests that soymilk isoflavones for 3
months treatment may be a safe and effective alternative therapy for menopausal
symptoms and may offer a benefit to enhance antioxidant status to improve
women health and quality of life.]]>Anderson, J.W., B.M. Johnstone and M.E. Cook-Newell,1995333276282Albright, C. and D.L. Thompson,200615271280Albertazzi, P., F. Pansini and G. Bonaccorsi et al.,199891611Adlercreutz, H.,1990201323Bonnier, P., S. Romain, P.L. Giacalone, F. Laffargue, P.M. Martin and L. Piana,1995851117Bernsen, R.M. and N.J. Nagelkerke,200760309317Boroditsky, R.S.,200045273284Benzie, I.F.F. and J.J. Strain,19962397076Crawford, L.E., E.E. Milliken, K. Irani, J.L. Zweier, L.C. Becker and T.M. Johnson et al.,19962712686326867Diplock, A.T., 19963410131020Dalais, F.S., G.E. Rice, M.L. Wahlqvist, M. Grehan, A.L. Murkies, G. Medley, R. Ayton and B.J. Strauss,19981124129Elavsky, S. and E. McAuley,2007228392Glazier, M.G. and M.A. Bowman,200116111611172Hanachi, P., O. Fauziah, L.T. Peng, L.C. Wei, L.L. Nam and T.S. Tai,2004Azadirachta indica) on distribution of antioxidant elements and glutathione S-transferase activity in liver of rats during hepatocarcinogenesis.]]>13S170S170Hanachi, P., S.H. Kua, R. Asmah, G. Motalleb and O. Fauziah,2006Berberis vulgaris fruit extract on the proliferation of human liver cancer cell line (HepG2) and its antioxidant properties.]]>219Ji, L.L.,199325225231Kokkinos, P.F., P. Narayan and V. Papademetriou,200119507516Kupperman, H.S., B.B. Wetchler and M.H.G. Blatt,195917116271637Kurzer, M.S. and X. Xu,199717353381Larun, L., L.V. Nordheim, E. Ekeland, K.B. Hagen and F. Heian,20063CD004691CD004691Lock, M.,1986102346Nemoto, K., H. Gen-no, S. Masuki, K. Okazaki and H. Nose,200782803811North American Menopause Society,20007215229Nestel, P.J., S. Pomeroy, S. Kay, P. Komesaroff, J. Behrsing and J.D. Cameron,199984895898Rose, D.P., A.P. Boyar and E.L. Wynder,19865823632371Scambia, G., D. Mango, P.G. Signorile, R.A.A. Anselmi and C. Palena et al.,20007105111Scharbo-Dehaan, M.,199621113This, P., A. De La Rochefordiere, K. Clough, A. Fourquet and H. Magdelenat,20018129134Tikkanen, M.J., K. Wahala, S. Ojala, V. Vihma and H. Adlercreutz,19989531063110Upmalis, D.H., R. Lobo, L. Bradley, M. Warren, F.L. Cone and C.A. Lamia,20007236242Wei, H., R. Bowen, Q. Cai, S. Barnes and Y. Wang,1995208124130Willett, W.C.,19988245253