Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2008.591.597NaseriFatemeh Mahdavi ShahriNasser SardariKamran MoghimiAli Reza BahramiAhmad KheirabadiMasoumeh Amin EdalatmaneshMohamad 3200883The aim of this study was to clarify whether of Bone
Marrow Myeloid tissue decreases the period of regeneration of tendon and
enhances healing. Fifteen New Zealand white rabbits, with body
weight ranging from 2.5 to 3 kg were used in this study, divided into
three groups, five of each. The Achilles tendons were damaged by collagenase
injection. Bone Marrow aspirated from the iliac crest and were injected
to the injured tendon of the right leg and normal saline into the control
leg. The animals were euthenized after 10, 20 and 30 days, respectively
and tendon samples were taken for histopathologic examinations. Histopathologic
observation demonstrated that Bone Marrow injections resolved edema, swelling
and inflammatory cell infiltration in injured tendons. Also different
degrees of increased fibroblast hypercellularity and vascularity were
seen. In this experiment, the cellularity, vascularity, collagen density
and collagen fibril organization were examined within and between the
groups 10, 20 and 30 days after collagenase injection (p>0.05). The
results showed no significant differences within the control and treatment
groups and also between the control groups (p>0.05). However, significant
differences were obvious between the treatment groups of 10, 20 and 30
days after collagenase injection (p<0.05). According to the results
of the present study, injection of the bone marrow myeloid tissue may
have effects on tendon healing in rabbit, as assessed by histopathological
examination, compared to control group.]]>Ackermann, P., W.L.J.T. Lundeberg and A. Kreicbergs,200321432441Anaguchi, Y., K. Yasuda, T. Majima, H. Tohyama, A. Minami and K. Hayashi,200520959965Atasoyn, N., M. Genccelep, A. Tas and M.Y. Gulbahar,2001121619Awad, H.A., D.L. Butler and G.P. Boivin et al.,19995267277Awad, H.A., G.P. Boivin, M.R. Dressler, F.N.L. Smith, R.G. Young and D.L. Butler,200321420431Becker, H., M.F. Graham, I.K. Cohen and R.F. Diegelmann,19816616619Butler, D. and H. Awad,1999367324332Chbinou, N. and J. Frenette,2003286R952R957Chen, Y.J., C.J. Wang, K.D. Yang, Y.R. Kuo, H.C. Huang and Y.T. Huang et al.,200422854861Cherdchutham, W., C.K. Becker, R.K. Smith, A. Barneveld and P.R. Van Weeren,1999318694Chhabra, A., D. Tsou, R.T. Clark, V. Gaschen, E.B. Hunziker and B. Mikic,200321826835Cohen, I.K.,198525410412Cribb, A.M. and J.E. Scott,1995187423428Dahlgren, L.A., M.CH. Meulen, J.E.A. Bertram, G.S. Starrak and A.J. Nixon,200220910919Dow, S.M., A. Wilson and A.E. Goodship,1996139413416Dowling, B.A. and A.J. Dart,2005170184192Fenwick, S.A., B.L. Hazleman and G.P. Riley,20024252260Forslund, C.,200374130Garner, W.L., J.A. McDonald, C. Kuhn III and P.M. Weeks,1988in vitro.]]>13697700Garneti, N., C. Holton and A. Shenolikar,200513220223Gibson, K.T., H.M. Burbidge and I.D. Robertson,200250186194Harris, M.T., D.L. Butler, G.P. Boivin, G.B. Florer, E.J. Schantz and R.J. Wenstrup,2004229981003Haupt, J.L., B.P. Donnelly and A.J. Nixon,20066715951600Hefti, F. and T.M. Stoll,199524237245Hosaka, Y., R. Kirisawa, M. Yamaguchi and K. Takehana,200567985991Howard, R.D. and C.M. Mcllwraith,19961996Juncosa, N., J.R. West, M.T. Galloway, G.P. Boivin and D.L. Butler, 2003In vivo forces used to develop design parameters for tissue engineered implants for rabbit patellar tendon repair.]]>36483488Kawamura, S., L. Ying, H.J. Kim, C.h. Dynybil and S.A. Rodeo,20052314251432Koike, Y., G. Trudel and H.K. Uhtho,20052314331440Koob, T.J.,200213311711192Leung, K.S., L. Qin, L.K. Fu and C.W. Chan,200217594602Lundborg, G. and F. Rank,198012311Marxen, S., J.C. de Lacerda-Neto, J.R.E. de Moraes, G. Ribeiro and A. de Queiroz-Neto,2003204346Moyer, K.E., A.A. Saba, R.M. Hauck and H.P. Ehrlich,2003758088Ouyang, H.W., G.C.H. Goh and E.H. Lee,200432321327Young, R.G., D.L. Butler, W. Weber, A.I. Caplan, S.L. Gordon and D.J. Fink,199816406413Sardari, K., E.G. Kakhki and M. Mohri,200716197200Stashak, T.S.,19911991pp: 238-257pp: 238-257Wang, C.J., F.SH. Wang, K.D. Yang and L.H. Weng,200321984989Wang, C.J., F.SH. Wang, K.D. Yang, L.H. Weng, Y.C. Sun and Y.J. Yang,200623274280Watkins, J.P., J.A. Aure, S.J. Morgan and S. Gay,19854620972103Weiler, A., F.N. Unterhauser, H.J. Bail, M. Huning and N.P. Haas,200220310317Willmen, M.A., H.H.C.M. Savelberg and A. Barnveld,1999312530Woo, S.L.Y., K. Hildebrand, N. Watanabe, J.A. Renwick, C.D. Papageorgiou and J.H.C. Wang,1999367312323Yamamoto, E., D. Hata, A. Kobayashi, H. Ueda and P. Tangkawattana,2002126161170Young, R.G., D.L. Butler, W. Weber, A.I. Caplan, S.L. Gordon and D.J. Fink,199816406413