Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2008.584.590Indigofera tinctoria is Through Cell Cycle Arrest and Apoptotic Pathway in A-549 Cells]]>Ravichandran KameswaranThiruvanmiyoor RamanibaiRavichandran 3200883The aerial parts of the plant was investigated for its
antiproliferative activity in human Non Small Cell Lung Cancer cells A-549.
The results showed that the flavanoidal fraction of methanolic extract
of the aerial parts of the plant inhibited the proliferation of A-549
cells as measured by MTT assay. Flow cytometric analysis showed that flavanoidal
fraction of methanolic extract of I. tinctoria blocked cell cycle
progression in G0/G1 phase. In addition flavanoidal fraction of methanolic
extract of I. tinctoria induced A-549 cell apoptosis as determined
by propidium iodide staining. We suggests that flavanoidal fraction of
methanolic extract of I. tinctoria activity might be potentially
contribute to its overall chemo preventive effect against lung cancer
and can possibly be considered for future therapeutic application.]]>Belloc, F., P. Dumain, M.R. Boisseau, C. Jalloustre, J. Reiffers, P. Bernard and D.F. Laeombe,199417159165Brown, J.M. and B.G. Wooters,199953 and tumor cell sensitivity to anticancer agents.]]>5913911399Chatterjee, A. and S.C. Pakrashi,1992Chen, Q., W. Peng and A. Xu,2002Thalictrum acutifolium (Hand.-Mazz) Bovin.]]>6313891396Cheng, Y.L., W.L. Chang, S.C. Lee, Y.G. Lio and H.C. Lin et al.,20037323832394Chopra,19568416420Chunekar, K.C. and B. Nighatu,19931993pp: 406pp: 406Han, R.,1994125363Hengartner, M.O.,2000407770776Kim, P.K., S.Y. Park, P.P. Koty, Y. Hua, J.D. Luketich and T.R. Billiar,200312513361342Kuo, S.M.,1996in situ perfused in liver.]]>454148Lieberthal, W., J.S. Koh and J.S. Levine,1998181505518May, P. and E. May,199953 research: Structural and functional aspects of the p53 protein.]]>1876217636Mosmann, T.,1983655563Nicoletti, I., G. Migliorati, M.C. Pagliacci, F. Grignani and C. Riccardi,1991139271279Price, R.M. and E. Jr. Middleton,19861986pp: 507-509pp: 507-509Han, R.,199496179Saija, A., M. Scalese, M. Lanza, D. Marzullo, F. Bonina and F. Castelli,199519481486Searle, J., T.A. Lawson, P.J. Abbott, B. Harmon and J.F.R. Kerr,1974116129138Singh, B., A.K. Saxena, B.K. Chandan, V. Bhardwaj, V.N. Gupta, O.P. Suri and S.S. Handa,2004Indigofera tinctoria Linn.]]>115274277Spinozzi, F., M.C. Pagliacci, G. Migliorati, R. Moraca, F. Grignani, C. Riccardi and I. Nicoletti,199418431439Sreepriya, H., T. Devaki and M. Nayeem,2001Indigofera tinctoria against D-galactosamine and carbon tetra chloride on in situ perfused in liver.]]>452834Steriti, R.,20027404409Surh, Y.J.,1999428305327Xiujuan,1981Indigofera tinctoria against Lewis lung carcinoma.]]>9431438Yanagihara, K., A. Ito, T. Toge and M. Numoto,19936358155821Zimmermann, K.C., C. Bonzon and D.R. Green,2001925770