Journal of Biological Sciences1727-30481812-5719Asian Network for Scientific Information10.3923/jbs.2007.161.168Piper longum (Linn.)Dried Fruits in Alloxan Induced Diabetic Rat]]>ManoharanShanmugam SilvanSimon VasudevanKrishnamoorthi BalakrishnanSubramanian 1200771Piper longum (Piperaceae family) is used in Indian traditional medicine as a remedy for various disorders including diabetes mellitus. The aim of the present study was to investigate the antihyperglycemic and antilipidperoxidative effects of ethanolic extract of Piper longum dried fruits (PLEFet) in alloxan induced diabetic rats. Diabetes mellitus was induced in overnight fasted (12 h) Wistar rats by single intraperitoneal injection of freshly prepared solution of alloxan monohydrate (150 mg kg-1 bw) in physiological saline. The blood glucose level, carbohydrate metabolizing enzymes and the status of lipid peroxidation and antioxidants were assayed using specific colorimetric methods. Oral administration of PLEFet hasshown significantantihyperglycemic, antilipidperoxidative and antioxidant effects in diabetic rats. PLEFet also corrected the metabolic alterations observed by the activities of several carbohydrate metabolizing enzymes (hexokinase, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, fructose 1.6-bisphosphatase and glycogen phosphorylase) in alloxan induced diabetic rats. The antihyperglycemic effect of PLEFetis comparable to that of the standard reference drug, glibenclamide. Present results indicate that PLEFet has potent antihyperglycemic and antilipidperoxidative effects in alloxan induced diabetic rats. PLEFet can therefore be used as an alternative remedy for diabetes and oxidative stress associated diabetic complications.]]>Al-Shamaony, L., S.M. Al-Khazraji and H.A.A. Twaiji,1994Artemisia herba alba. II. Effect of a valuable extract on some blood parameters in diabetic animals.]]>43167171Anderson, L., B. Dinesen, P.N. Jorgesen, F. Poulsen and M.F. Roder,199339578582Atal, C.K., R.K. Dubey and J. Singh,1985232258262Atlanta, G.A.,20022002Beutler, E. and B.M. Kelley,1963299697Boyle, J.P., A.A. Honrycult, K.M. Narayan, T.J. Hoerger, L.S. Geiss, H. Chen and T.J. Thompson, 20012419361940Brandstrup, N., J.E. Kirk and C. Bruni,195712166171Ceriello, A.,2000492729Clement, K., M.E. Pneyo, M. Vaxillaire, Rako B. Toambina, F. Thuillier and P. Passa,1996398290Dodge, J.T., C. Mitchell and D.J. Hanahan,1963100119130Donnan, S.K.,19501982415419Drabkin, D.L. and J.M. Austin,193298719733Ellis, H.A. and H.N. Kirkman,1961106607609Gancedo, J.M. and C. Gancedo,197176132138Grankvist, K., S. Marklund, J. Sehlin and I.B. Taljedal,1979in vitro.]]>1821725Halliwell, B. and J.M.C. Gutteridge,198432313961397Jiang, Z.Y., J.V. Hunt and S.P. Wolff,1932202384387Joshi, S.G.,2000pp: 281-282pp: 281-282Kakkar, P., B. Das and P.N. Viswanathan,198421130132King, H., R.E. Aubert and W.H. Herman,19982114141431Kirkman, H.M., S. Galiano and G.F. Gaetani,1987262660665Koenig, R.J., C.M. Peterson, R.L. Jones, C. Saudek, M. Lehrman and A. Cerami,19761C in diabetes mellitus.]]>295417420Koida, H. and T. Oda,19594554561Mahdi, A.A.,20022002pp: 545-555pp: 545-555Malaisse, W.J., F. Malaisse-Lagae, A. Sener and D.G. Pipeleers,198279927930Malaisse, W.J.,19823135273534McCord, J.M., B.B. Keele Jr. and I. Fridovich,19716810241027Morales, M.A., A.J. Jobbagy and H.F. Terenzi,1973202425Ohkawa, H., N. Ohishi and K. Yagi,197995351358Omaye, S.T., J.D. Turnbull and H.E. Sauberlich,197962311Punitha, R. and S. Manoharan,2006Pongamia pinnata (Linn.) Pierre flowers in alloxan induced diabetic rats.]]>1053946Punitha, R., K. Vasudevan and S. Manoharan,2006386263Quist, E.H., 19802+.]]>92631637Ravi, K., B. Ramachandran and S. Subramanian,2004Eugenia jambolana seed kernel on tissue antioxidants in streptozotocin-induced diabetic rats.]]>2712121217Rotruck, J.T., A.L. Pope, H.E. Ganther, A.B. Swanson, D.G. Hafeman and W.G. Hoekstra,1973179588590Sakurai, K. and T. Ogiso,199139737742Sasaki, T., S. Matsy and A. Sonae,19721346353Seghrouchni, I., J. Drai, E. Bannier, J. Riviere, P. Clamard, I. Garcia, J. Orgiazzi and A. Revolm,20023218996Selvendiran, K., J. Prince Vijeya Singh, K. Baba Krishnan and D. Sakthisekaran,200374109115Shull, K.H., J. Ashmore and J. Mayer,195662210216Sies, H.,1993215213219Sinha, A.K.,197247389394Slater, T.F.,1984222115Nayak, S.S. and T.N. Pattabiraman,1981109267274Sunila, E.S. and G. Kuttan, 2004Piper longum Linn. and piperine.]]>90339346Tannaka, Y., P.O. Tran, J. Harmon and R.P. Robertson,2002991236312368Urger, R.H. and D.W. Foster,19981998pp: 973-1060pp: 973-1060Yagi, K.,198745337351