Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2019.537.543atp/Bkca Ion Channels in Rats]]>E. NkanuEtah U. OwuDaniel E. OsimEme 62019196Background and Objective: Extra virgin olive oil is consumed in most areas of the Mediterranean and the tropics and has been reported to be involved in the lowering of arterial blood pressure. The aim of this study was to determine the possible mechanism of arterial blood lowering effect of extra virgin olive oil and palm oil diets. Materials and Methods: Male Wistar rats (10 rats per group) were fed on normal rat chow (control), Fresh Palm Oil (FPO), Extra Virgin Olive Oil EVOO) and Thermoxidized Palm Oil (TPO) groups. The oil-fed groups received 15% (weight/weight) of oil mixed with rat chow for 18 weeks. Blood pressure was measured by direct cannulation and blood samples, heart and kidney were collected for biochemical analysis. Results: The basal Systolic Blood Pressure (SBP) and after phenylephrine (106 mmol L1) infusion was significantly (p<0.01) elevated in EVOO, FPO and TPO compared with control. Levcromakalim (106 mmol L1) (a KATP-channel opener) and NS1619 (Bkca channel opener) infusion significantly (p<0.01) reduced mean arterial pressure (MAP) in FPO and EVOO compared with control and TPO. Heart and kidney SOD and catalase activities were significantly (p<0.05) increased in EVOO and FPO groups when compared with other groups but decreased in TPO. Conclusion: Long term intake of thermally oxidized palm oil may suppress potassium ion channel function thereby increasing blood pressure. Blood pressure reduction property in FPO and EVOO is via KATP and Bkca ion channels and the greater effect of EVOO is probably due to its high content of oleic acid and polyphenols.]]>Psaltopoulou, T., A. Naska, P. Orfanos, D. Trichopoulos, T. Mountokalakis and A. Trichopoulou,20048010121018Owen, R.W., W. Mier, A. Giacosa, W.E. Hull, B. Spiegelhalder and H. Bartsch,200038647659Covas, M.I., R. de la Torre and M. Fito,2015113S19S28Guasch-Ferre, M., F.B. Hu, M.A. Martinez-Gonzalez, M. Fito and M. Bullo et al.,20142014Leong, X.F., A. Aishah, U. Nor Aini, S. Das and K. Jaarin,200839567572Langley-Evans, S.C., A.G. Clamp, R.F. Grimble and A.A. Jackson,199647417425Lahoz, C., R. Alonso, J.M. Ordovas, A. Lopez-Farre, M. de Oya and P. Mata,199727780787Newaz, M.A., Z. Yousefipour, N. Nawal and N. Adeeb,200354319327Perona, J., R. Cabello-Moruno and V. Ruiz-Gutierrez,200617429445Gilani, A.H., A.U. Khan, A.J. Shah, J. Connor and Q. Jabeen,200556613620Edem, D.O.,200257319341Mukherjee, S. and A. Mitra,200926197203Adam, S.K., N.A. Sulaiman, A.G.M. Top and K. Jaarin,2007157679Manorama, R., N. Chinnasamy and C. Rukmini,199331583588Osim, E.E., D.U. Owu and K.M. Etta,199625335340Garrido-Polonio, C., M.C. Garcia-Linares, M.T. Garcia-Arias, S. Lopez-Varela, M.C. Garcia-Fernandez, A.H. Terpstra and F.J. Sanchez-Muniz,200492257265Owu, D.U., E.E. Osim and N.N. Orie,1997268386Iwata, N.G., M. Pham, N.O. Rizzo, A.M. Cheng, E. Maloney and F. Kim,20112011Sobey, C.G.,2001212838Nkanu, E.E., D.U. Owu and E.E. Osim,201815431444Owu, D.U., E.E. Osim and P.E. Ebong,1998696573Misra, H.P. and I. Fridovich,197224731703175Sinha, A.K.,197247389394Ohkawa, H., N. Ohishi and K. Yagi,197995351358Leong, X.F., M.N.M. Najib, S. Das, M.R. Mustafa and K. Jaarin,20092197178Storniolo, C.E., R. Casillas, M. Bullo, O. Castaner and E. Ros et al.,2017568997Zimmerman, J. and M. Cahalan,20132013pp: 390-404pp: 390-404Teres, S., G. Barcelo-Coblijn, M. Benet, R. Alvarez, R. Bressani, J.E. Halver and P.V. Escriba,20081051381113816Yang, Q., R. Alemany, J. Casas, K. Kitajka, S.M. Lanier and P.V. Escriba,200568210217Hansen, K. and O.A. Nedergaard,199941153159Ferrara, L.A., A.S. Raimondi, L. d'Episcopo, L. Guida, A.D. Russo and T. Marotta,2000160837842Visioli, F., A. Poli and C. Gall,2002226575Montoya, C., B. Cochard, A. Flori, D. Cros and R. Lopes et al.,2014Elaeis guineensis Jacq.) compared to its wild relative E. oleifera (HBK) Cortes.]]>2014Gao, Y.J. and R.M.K.W. Lee,20012 production.]]>13416391646Brakemeier, S., I. Eichler, A. Knorr, T. Fassheber, R. Kohler and J. Hoyer,20032+-activated K+ channel in renal artery endothelium in situ by nitric oxide and reactive oxygen species.]]>64199207McGahon, M.K., D.P. Dash, A. Arora, N. Wall and J. Dawicki et al.,20072+-activated potassium β1 channel subunit in retinal arteriolar smooth muscle.]]>100703711Boon, C.M., M.H. Ng, Y.M. Choo and S.L. Mok,20132013Jaarin, K., M.R. Mustafa and X.F. Leong,20116621252132Villarejo, A.B., M. Ramirez-Sanchez, A.B. Segarra, M. Martinez-Canamero and I. Prieto,201581664669Leong, X.F., M.R. Mustafa, S. Das and K. Jaarin,20102010Gonzalez-Correa, J.A., J. Munoz-Marin, M.M. Arrebola, A. Guerrero, F. Narbona, J.A. Lopez‐Villodres and J.P. de la Cruz,200742921929