Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2019.303.310Chrozophora tinctoria as Hepatoprotective Potential in CCl4 Induced Liver Damage in Rat]]>MauryaHarikesh UpadhyayGaurav 42019194Background and Objective:Chrozophora tinctoria is a monoecious shrubby herb traditionally used as food supplement and in the treatment of various infectious diseases. Leaves were shown high content diterpenes, flavonoids and chromone glycosides possessing antioxidant potential. The study was designed to evaluate hepatoprotective effect of Chrozophora tinctoria leaves in carbon tetrachloride (CCl4) induced liver damage in Wistar rats and to validate its traditional claims. Materials and Methods: Thirty Wistar rats (180-200 g) of either sex were randomly divided into 5 groups (n = 6) such as Group 1 served as the normal control (0.9% Saline); Group 2 rats were administered with CCl4 1.5 mL kg1 i.p. prepared in 20% olive oil for induction of hepatotoxicity, Group 3 and 4 rats were orally administered with the hydro-alcoholic leaves extract of C. tinctoria at a low dose 50 mg kg1 and a high dose 100 mg kg1, respectively; Group 5 rats treated with Silymarin 25 mg kg1 orally as standard drug for a period of 28 days. At the end of the study, the blood samples were collected for biochemical parameters in liver, antioxidant analysis and the liver tissue for histological analysis. Results: The CCl4 treated rats developed hepatotoxicity that evident by the elevated level of AST, ALT, ALP, bilirubin, proteins, albumin and the antioxidant enzymes like CAT, SOD, GGT and GST. 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