Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2018.65.70Z. HamzaReham A. Al-SalmiFawziah S. El-ShenawyNahla 22018182Background and Objective: The potential benefit of green synthesis zinc oxide nanoparticles (ZnO NPs) is still a deprecatory issue. The aim of the present research was to elucidate the anti-hyperlipidemia of green tea leaves extract (GTE)/ZnO NPs complex against monosodium glutamate (MSG). Materials and Methods: Eight different groups of male rats were used: Group I was the control, group II received GTE (1 mg mL1), group III was treated with ZnO NPs (10 mg kg1), groups IV and V received MSG in two different doses (6.0 and 17.5 mg kg1), group VI treated with ZnO NPs/GTE complex, groups VII and VIII were given ZnO NPs/GTE complex plus MSG in different doses. The effect of ZnO NPs/GTE complex against MSG toxicity through studying the alteration of enzyme activity of liver functions [alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), alkaline phosphatase (ALK) and γ-glutamyl transferase (γ-GT)] and lipid profile alternation have been described. The rats that were given MSG only had a highly significant elevation in liver enzymes and severe lipid metabolism changes. Results: The findings for group VII and VIII clarify the efficacy of ZnO NPs/GTE complex as a hepato-protectant on MSG alone through improving the liver enzyme activity along with the lipid profile. The activities of ALT, AST, LDH, ALP and γ-GT in the serum were significantly reduced. Conclusion: ZnO NPs/GTE complex was proved to be a potential hepatoprotective as it significantly ameliorates the hepatotoxicity induced by MSG through hyperlipidemia reducing effect.]]>Khan, S.T., J. Musarrat and A.A. Al-Khedhairy,20161467083Ali, K., S. Dwivedi, A. Azam, Q. Saquib, M.S. Al-Said, A.A. Alkhedhairy and J. Musarrat,2016Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates.]]>472145156Al-Salmi, F.A., R.Z. Hamza and N.S. El-Shenawy,20182018Kuriyama, S.,201074248249Deka, A. and J.A. Vita,201164136145Suzuki, Y., N. Miyoshi and M. Isemura,20128888101Ryu, S.D. and W.G. Chung,200341861866Islam, M.A.,201278899Cabrera, C., R. Artacho and R. Gimenez,2006257999Speciale, A., J. Chirafisi, A. Saija and F. Cimino,201111770789Diniz, Y.S., A.A.H. Fernandes, K.E. Campos, F. Mani, B.O. Ribas and E.L.B. Novelli,200442313319Husarova, V. and D. Ostatnikova,20132013Burtis, C.A. and E.R. Ashwood,19993th Edn.,Hung, M.T., C.T. Ho, Z.Y. Wang, T. Ferraro and T. Finnegan-Olive et al.,199213947954Hamza, R.Z. and M.S. Al-Harbi,2014110371045Ben-Slama, I., I. Mrad, N. Rihane, L.E. Mir, M. Sakly and S. Amara,20152015Carr, T.P., C.J. Andresen and L.L. Rudel,1993263942Warnick, G.R., J. Benderson and J.J. Albers,1983Vol. 10,pp: 91-99pp: 91-99Friedewald, W.T., R.I. Levy and D.S. Fredrickson,197218499502Al-Harbi, M.S., N.S. El-Shenawy and N.O.S. Al-Weail,201436167176Inuwa, H.M., V.O. Aina, B. Gabi, I. Aim Ola and L. Ja'afaru,20112148153Singh, K., J. Sharma, A. Kaur and P. Ahluwalia,201131721Amanolahi, F. and H. Rakhshande,2013398105Zulet, M.A., A. Barber, H. Garcin, P. Higueret and J.A. Martinez,1999183642Yost, T.J., K.K. Froyd, D.R. Jensen and R.H. Eckel,199544786790Egbuonu, A.C.C., O. Obidoa, C.A. Ezeokonkwo, L.U.S. Ezeanyika and P.M. Ejikeme,2009830313035Akanya, H.O., S. Peter, I.F. Ossamulu, F.I. Oibiokpa and H.Y. Adeyemi,20156113120Bain, P.J.,20032003pp: 193-214pp: 193-214El-Shenawy, N.S.,20102411481157Poupon, R.,20156120802090Rahmani, A.H., K.S. Allemailem, S.M. Aly and M.A. Khan,20152015