Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2013.924.928OtutuJ.O. EfurhievweE.M. 62013136The quinazoline skeleton is an important part of many alkaloids and has been isolated from some plants such as those obtained from the Rutacea family. The quinazoline moieties have been found to exhibit many pharmacological properties and such when used to prepare dyes could show some friendly influence on humans. In view of these, this study described the synthesis of monoazo dyes from 4-amino-2-chloro-6,7-dimethoxyquinazoline. The 4-amino-2-chloro-6,7-dimethoxyquinazoline was diazotized and coupled with arylamine and phenolic coupling compounds to afford six monoazo disperse dyes. The results of the absorption maxima of the dyes were found to depend on the substituents in the diazo and coupling components and varied from 370 nm to 517 nm and 704 nm in dimethylformamide (DMF). The dyes on polyester fabrics and acrylics fabrics showed good fastness to light and washing but excellent fastness to sublimation. Thus, the results of the investigation revealed that the dyes have affinity for the two substrates (polyester fibre and acrylic fibre). The dyes were characterized, using IR, 1H NMR, 13C NMR and UV-Visible analysis.]]>AATCC,1993 1993 Burkinshaw, S.M.,19941994pp: 326-331pp: 326-331Campbell, S.F., M.J. Davey, J.D. Hardstone, B.N. Lewis and M.J. Palmer,1987304957Giles, C.H.,1974pp: 93-101pp: 93-101ISO,19931993ISO,19941994Joseph, A., P. Aravinda, K.K. Srinivasan, K. Tukaram, T.T. Angel, E.M. Jessy and K.S. Rajeev,20102158167Karci, F.,2005121275280Otutu, J.O., E. Osabohien and E.M. Efurhievwe,20112713691396Paula, Y.B.,19951st Edn.,pp: 658-659pp: 658-659Samieh, F., M.T. Ahmad, H. Hoosbang and K. Hojatollah,200815115123Shuttleworth, L. and M.A. Weaver,19901990Suwanruji, P., H.S. Freeman and D. Zhao,2004120220225Zollinger, H.,20033rd Edn.,pp: 68-69pp: 68-69Evans, N.A. and I.W. Stapleton,19781978pp: 221-227pp: 221-227