Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2013.722.728XiaoKefeng HaoZhihui HuDedong WangLeilei 52013135Solution Enhanced Dispersion by Supercritical fluid (SEDS)
process is utilized more and more widely for preparing nano-drug. Nozzle is
the key component in SEDS process. In this study, the flow in jet-swirl nozzle
for preparing nano-drug in SEDS process was analyzed by Computational Fluid
Dynamics (CFD). It can be concluded from the results that the jet mixing length
was found to be a strong function of the volume flow of supercritical CO2
(SC-CO2) at the inlet of the swirl chamber. When the volume flow
of SC-CO2 was equal to or greater than 25 mL min-1, methylene
chloride and SC-CO2 mixed completely in the nozzle. These results
were coincident with the results obtained from experiments in literature. In
additional, it also was indicated that the turbulent intensity at the outlet
was all even in different volume flow of SC-CO2 and with the increase
of volume flow of SC-CO2, the turbulent intensities at the outlet
become greater and greater. These results were similar with the results obtained
from experiments in literature. By these CFD analysis and comparison with literature,
the flow parameters in jet-swirl nozzle were revealed and the method of CFD
analysis for SEDS process was validated.]]>Baldyga, J., D. Kubicki, B.Y. Shekunov and K.B. Smith,20108811311141He, W.Z., Q.L. Suo, Z.H. Jiang, S. Ab and H.L. Hong,200431101110Jarmer, D.J., C.S. Lengsfeld and T.W. Randolph,200327317336Leybros, A., R. Piolet, M. Ariane, H. Muhr, F. Bernard and F. Demoisson,2012701726Liu, Y., Y. P. Qu and W.Q. Wang,20112011Moussiere, S., A. Roubaud, O. Boutin, P. Guichardon, B. Fournel and C. Joussot-Dubien,2012652531Reverchon, E., G. Della Porta, I. De Rosa, P. Subra and D. Letourneur,200018239245Shekunov, B.Y., M. Hanna and P. York,1999198-19913451351Subramaniam, B.,19981998Thiering, R., F. Dehghani and N.R. Foster,200121159177Xiao, K.F. and X. Ma,200736486488