Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2010.1802.1805SohrabiM.R. EmrarianM. JavanbakhtM. 1220101016The H-Point Standard Addition Method (HPSAM) has been applied for simultaneous determination of levonorgestrel (LEV) and ethinylestradiol (ETE) in contraceptive LD pill. LEV and ETE can be determined simultaneously in the range of 0.50-5.00 and 0.20-8.00 μg mL-1, respectively with satisfactory accuracy and precision. The proposed method has successfully been applied for the simultaneous determination of both compounds in several synthetic samples and Iranian commercial low-dose oral contraceptives. A Limit of Detection (LOD) of LEV and ETE was obtained 0.011 and 0.010 μg mL-1, respectively for synthetic samples. The standard error (Er) of LEV and ETE was obtained 3.33 and 4.16%, respectively. This procedure for simultaneous determination of LEV and ETE is sensitive and easy to perform.]]>Pollow, K., R. Sinnecker and B.J. Pollow,197490402404Verna, P., C. Curry, C. Crocker, T.P. Dillon and B. Ahluwalia,197563363368Penzes, L.P. and G.W. Oertel,197274359363Eldawy, M.A., A.S. Tawfik and S.R. Elshabouri,19756412211223Lisboa, B.P. and M. Strassner,1975111159163Graham, R.E. and C.T. Kenner,19736218451849Berzas, J.J., J. Rodriguez and G. Castaneda,19971224144Gustafsson, K.H. and C.H. Fallgren,198331461463Bosch-Reig, F. and P. Campins-Falco,198811310111016Bosch-Reig, F., P. Campins-Falco and M.J. Cardone,1990115111113Bosch-Reig, F., P. Campins-Falco and J. Verdu-Andres,1992270253265Sun, L., W. Yong, X. Chu and J.M. Lin,2009121654165423Nevado, J.J.B., J.R. Flores and G.C. Penalvo,1997340257265Prabhakar, B. and S.G. Deshpande,1999611215