Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2008.1235.1241Saif DehwahMustafa Abdo ShuangZhang YanWang ChanPeng HuangQing-Yang 7200887The aim of this study was to investigate the association between Pro12Ala polymorphism in the PPARγ2 gene and type 2 diabetes mellitus in Han Chinese in Hubei. Peroxisome proliferator activated receptorγ2 (PPARγ2) is a nuclear receptor plays a key role in regulation of adipocyte differentiation, lipid metabolism, insulin sensitivity and the development of type 2 diabetes mellitus (T2DM). There are various studies have provided evidence for the association between common Pro12Ala polymorphism in the PPARγ2 gene and type 2 diabetes mellitus, but the results are controversial and depend on ethnicity. So we conducted a case-control association study among 330 T2DM patients and 212 controls with family-based and random case-control designs. The genotypes of the PPARγ2 Pro12Ala polymorphism were detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFL) method. The result indicated that the Pro12 allele was associated with type 2 diabetes in this study population.]]>Altshuler, D., J.N. Hirschhorn, M. Klannemark, C.M. Lindgren and M.C. Vohl et al.,2000267680Beamer, B.A., C. Negri, C.J. Yen, O. Gavrilova and J.M. Rumberger et al.,1997233756759Deeb, S.S., L. Fajas, M. Nemoto, J. Pihlajamaki and L. Mykkanen et al.,199820284287Douglas, J.A., M.R. Erdos, R.M. Watanabe, A. Braun and C.L. Johnston et al.,200150886890Fajas, L., D. Auboeuf, E. Raspe, K. Schoonjans and A.M. Lefebvre et al.,19972721877918789Fajas, L., J.C. Fruchart and J. Auwerx,19984385560Frederiksen, L., K. Brodbaek, M. Fenger, T. Jorgensen, K. Borch-Johnsen, S. Madsbad and S.A. Urhammer,20028739893992Ghoussaini, M., D. Meyre, S. Lobbens, G. Charpentier and K. Clement et al.,2005618Gonzalez-Sanchez, J.L., M. Serrano-Rios, C. Fernandez-Perez, M. Laakso and M.T. Martinez-Larrad,2002147495501Hegele, R.A., H. Cao, S.B. Harris, B. Zinman, A.J. Hanley and C.M. Anderson,20008520142019Issemann, I. and S. Green,1990347645650King, H., R.E. Aubert and W.H. Herman,19982114141431Latruffe, N. and J. Vamecq,1997798194Lindi, V.I., M.I. Uusitupa, J. Lindstrom, A. Louheranta and J.G. Eriksson et al.,20025125812586Mancini, F.P., O. Vaccaro, L. Sabatino, A. Tufano and A.A. Rivellese et al.,19994814661468McCarthy, M. and S. Menzel,200151195199Meirhaeghe, A. and P. Amouyel,20048393102Mori, H., H. Ikegami, Y. Kawaguchi, S. Seino and N. Yokoi et al.,200150891894Oh, E.Y., K.M. Min, J.H. Chung, Y.K. Min and M.S. Lee et al.,20008518011804Ringel, J., S. Engeli, A. Distler and A.M. Sharma,1999254450453Soriguer, F., S. Morcillo, F. Cardona, G. Rojo-Martinez and M. de-la-Cruz-Almaraz et al.,200613623252330Spiegelman, B.M.,199847507514Sundvold, H. and S. Lien,2001287383390Tavares, V., R.D. Hirata, A.C. Rodrigues, O. Monte and J.E. Salles et al.,20057605611Vigouroux, C., L. Fajas, E. Khallouf, M. Meier and G. Gyapay et al.,199847490492Yen, C.J., B.A. Beamer, C. Negri, K. Silver and K.A. Brown et al.,1997241270274