Journal of Applied Sciences1812-56541812-5662Asian Network for Scientific Information10.3923/jas.2006.988.992In vitro Antimicrobial and in vivo Cytotoxic Activity of Some Ferrocene Derivative Bioactive Metal Complexes of First Transition Series]]>HaqueM.E. RahmanM.Z. HossenM. Faruk PervinM.M. KabirM.H. FerdausK.M.K.B. BariLuthfunnesa ZakariaC.M. HassanPervez KhalekuzzamanM. 5200665The aim of the present study was to investigate the antimicrobial and cytotoxic activities of five newly synthesized ferrocene based complexes [Mn(FcCOO)2, A], [Co(FcCOO)2, B], [Ni(FcCOO)2, C], [Cu(FcCOO)2, D] and [Zn(FcCOO)2, E]. The maximum antibacterial (at the concentration 100 μg disc-1) and antifungal (at the concentration 200 μg disc-1) activities were shown by the manganese complex A followed by cobalt complex B. The minimum activites were shown by Zink complex E. The minimum inhibitory concentration of the complexes was determined against four pathogenic bacteria Bacillus subtilis, Bacillus megaterinum, Escherichia coli and Shigella shiga and the values of complex A were found between 16-32 μg mL-1. Brine shirmp lethality bioassay was carried out and all the complexes also showed cytotoxic effect compared with the standard bleomycin (0.41 μg mL-1).]]>Bacchi, A., M. Careelli, P. Pelagatti, C. Pelizzi, G. Pelizzi and F. Zani,199915123133Bauer, A.W., W.M.M. Kirby, J.C. Sherris and M. Turck,196645493496Biswas, M.H.U., S.A.H. Zakaria, A. Farooque, C.M. Zakaria, S.M. Zakir, S. Sadik and S.M.A. Bhuiyan,2002In vitro antibacterial and cytotoxic activity of a benzene sulfonic acid derivative complex compound.]]>14346Chaudhary, A., N. Bansal, A. Gajraj and R.V. Singh,200396393400Dendrinou-Samara, C., L. Alevizopoulou, L. lordanldis, E. Samaras and D.P. Kessissoglou,2002898996Finney, D.J.,19713rd Edn.,pp: 76-80pp: 76-80Islam, M.R.,20002000Islam, M.S., M.A. Farooque, M.A.K. Bodruddoza, M.A. Mosaddik and M.S. Alam,20022797799Kamalakannan, P. and D. Venkappayya,2002212237Meyer, B.N., N.R. Ferrigni, J.E. Putnam, L.B. Jacobsen, D.E. Nichols and J.L. McLaughlin,1982453134McLaughlin, J.L. and J.E. Anderson,19881988pp: 2224McLaughlin, J.L.,19901990Mishra, L., M.K. Said, H. Itokawa and K. Takcya,1995312411245Persoone, G.,1980Artemia saline.]]>1980Reiner, R.,198222125Reich, J.W. and A.R., Gennaro,19908th Edn.,Rios, J.L., M.C. Recio and A. Villar,198823127149Saglam, N., A. Colak, K. Serbest, S. Dulger, S. Guner, S. Karabocck and A.O. Belduz,200215357364Sultana, C., M.A.A. Rahman, M.A.A.A. Bari, M.L.A. Banu, M.S. Islam, N.A. Khatune and G. Sadik,2003In vitro antimicrobial screening of three cadmium complexes and two addition compounds of antimony and arsenic.]]>6525527Zakaria, C.M., A. Farroque, M.R. Islam, M.A. Islam and M.H. Biswas,2000168590Zakaria, C.M., A. Farroque, M.R. Islam, M.A. Islam and M.H. Biswas,2001174750