International Journal of Zoological Research1811-97781811-9786Academic Journals Inc.10.3923/ijzr.2013.58.65Rosa canina
L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar
Rats]]>GholampourF. OwjiS.M. 2201392Recent studies have shown remote effects of renal Ischemia/Reperfusion (I/R)
injury on the liver. Furthermore, I/R injury is correlated with the generation
of Reactive Oxygen Species (ROS). This study investigated the effect of Rosa
canina on the hepatic dysfunction and histological damage induced by renal
ischaemia/ reperfusion at an early stage. There were three groups (n = 10),
in which rats received orally 7 days before induction of ischemia, extract of
Rosa canina (500 mg kg-1) in RC+I/R group and distilled water
in I/R group. In sham group, the renal arteries were not occluded and distilled
water was administered orally 7 days before surgery. Renal ischemia was induced
by both renal arteries occlusion for 45 min followed by 24 h of reperfusion.
Blood samples were collected for biochemical analysis and finally liver samples
were preserved for future histological examination. The renal ischaemic challenge
resulted in major histological damages of the liver (p<0.001), which were
associated with increased levels of creatinine, Blood Urea Nitrogen (BUN), alanine
aminotransferase (ALT) and aspartate aminotransferase (AST) during reperfusion
period (all p<0.001). In RC+I/R group, the histological damage to the liver
was improved (p<0.001) along with increased in plasma creatinine, BUN, ALT
and AST being smaller than those of the non-treated rats (p<0.001). Rosa
canina exhibited a hepatoameliorative effect against renal ischemia/reperfusion-induced
lesions.]]>Edelstein, C.L. and R.W. Schrier,20072007pp: 930-961pp: 930-961Kadkhodaee, M., G.R. Hanson, R.A. Towner and Z.H. Endre,1996253142Kadkhodaee M., M. Hemmati, M. Zahmatkesh, R. Ghaznavi and F. Mirershadi et al.,200812147151Sudha, A., K. Sumathi, S. Manikandaselvi, N.M. Prabhu and P. Srinivasan,20137113Noori, S., N. Rehman, M. Qureshi and T. Mahboob,20098452458Almansour, M.I.,20084165175Ahmed, R.G.,20062150168Cadenas, E.,19976391397Hajipour, B., M.H. Somi, F. Dibazar, N.A. Asi and A.M. Vatankhah,2010106670Pham-Huy, L.A., H. He and C. Pham-Huy,200848996Momtaz, S. and M. Abdollahi,2012 7119Ramchoun, M., H. Harnafi, C. Alem, M. Benlys and L. Elrhaffari et al.,2009Thymus vulgaris and Lavendula multifida.]]>1106112Nwaehujor, C.O., F.C. Nwinyi and O.O. Julius,20127182193Hussein, H.K. and O.A. Abu-Zinadah,20106266276Rein, E., A. Kharazmi and K. Winther,2004Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis-a double‐blind, placebo‐controlled, randomized trial.]]>11383391Orhan, D.D., A. Hartevioglu, E. Kupeli and E. Yesilada,2007In vivo anti inflammatory and antinociceptive activity of the crude extract and fractions from Rosa canina L. fruits.]]>112394400Wenzig, E.M., U. Widowitz, O. Kunert, S. Chrubasikc and F. Bucara et al.,2008in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations.]]>15826835Winther, K.,2008Rosa canina L.) improves function and reduces pain and the consumption of rescue medication in osteoarthritis.]]>16S8S9Tayefi‐Nasrabadi, H., S. Sadigh‐Eteghad and Z. Aghdam,2012Rosa canina L. fruit on experimentally nephrolithiasic Wistar rats.]]>267885Gholampour, F., T. Javadifar, S. Karimi, T. Eslam-Zadeh and S.M. Owji,2012Rosa canina L. fruit on ischemic acute renal failure in Wistar rats.]]>2114331438Kelly, K.J.,20031415491558Bhalodia, Y.S., N.R. Sheth, J.D. Vaghasiya and N.P. Jivani,201062530Pawliczak, R.,200314493496Cuzzocrea, S., M.C. McDonald, H.M. Filipe, G. Costantino and E. Mazzon et al.,2000390209222Leiro, J., E. Alvarez, J.A. Arranz, R. Laguna, E. Uriarte E and F. Orallo,20047511561165Los, M., M. Mozoluk, D. Ferrari, A. Stepczynska and C. Stroh et al.,200213978988Lin, Y., S. Choksi, H.M. Shen, Q.F. Yang and G.M. Hur et al.,20042791082210828Takeda, M., I. Shirato, M. Kobayashi and H. Endou,199981234238Renz, A., W.E. Berdel, M. Kreuter, C. Belka, K. Schulze-Osthoff and M. Los,2001in vivo.]]>9815421548Wolfreys, K. and D.B. Oliveira,199727297306Dabrowski, A., S.J. Konturek, J.W. Konturek and A. Gabryelewicz,1999377111Park, S.W., S.W.C. Chen, M. Kim, K.M. Brown and J.K. Kolls et al.,2011916384Kharazmi, A. and K. Winther,1999in vitro and reduces certain inflammatory parameters in vivo.]]>7377386Larsen, E., A. Kharazmi, L.P. Christensen and S.B. Christensen,2003Rosa canina) that inhibits chemotaxis of human peripheral blood neutrophils in vitro.]]>66994995Serteser, A., M. Kargioglu, V. Gok, Y. Bagci, M.M. Ozcan and D. Arslan,200859643651Kilicgun, H. and A. Dehen,2009In vitro antioxidant effect of Rosa canina in different antioxidant test systems.]]>1417420