International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2022.994.1003in silico Modeling Studies of Febuxostat in Gentamicin Induced Nephrotoxic Rats]]>AlqahtaniAli ChidambaramKumarappan AsseriKhalid VenkatesanKrishnaraju Ahmed QureshiAbsar AldahishAfaf AlqahtaniTaha AlghazwaniYahia Bin EmranTalha HassanHesham M. AsiriSaeed A. Abdulla KhanNoohu BalakumarPitchai 52022185Background and Objective: Febuxostat is used for the treatment of hyperuricemia that improves renal function in CKD patients, but its renal protective effect has not been fully studied. This study has been undertaken to evaluate the potential modulatory effects of febuxostat on renal dysfunction and kidney injury in an experimental model of gentamicin-induced nephrotoxicity in rats. Materials and Methods: These effects were assessed in terms of analysing biochemical (creatinine, urea, blood urea nitrogen, uric acid, serum electrolytes, alanine aminotransferase, aspartate transaminase and alkaline phosphatase, among others) parameters, total histological kidney score, as well as the histological assay of kidney and liver tissues. Results: As compared to gentamicin control (100 mg kg1) groups, the febuxostat (10 mg kg1, i.p.) pre/post-treatment was significantly preventive in terms of biochemical parameters and the total histological score of kidney tissue. Either pre/post-treatment markedly reduced the changes of glomerular enlargement, degeneration tubular hyaline casts and tubular degeneration, while the liver showed no remarkable changes in hepatocytes or liver architecture. Conclusion: This observation may have a great impact on the use of aminoglycosides, whereas febuxostat may have a key potential to prevent the associated renal toxicity induced by the administration of gentamicin.]]>Rosenberg, C.R., X. Fang and K.R. Allison,20202020Udupa, V. and V. Prakash,201969199Medić, B., M. Stojanović, B. Rovčanin, D. Kekić and S.R. Škodrić et al.,20192019Al-Azzam, S.I., K.K. Abdul-Razzak and M.W. Jaradat,2010228891Sun, B., X. Zhou, Z. Qu, L. Sun and G. Cheng et al.,20193007380Balakumar, P., A. Rohilla and A. Thangathirupathi,201062179186El-Moduem, M., G. Laurent, M.P. Mingeot-Leclercq, H.S. Taper, J. Cumps and P.M. Tulkens, 200044665675Pakfetrat, Z., S. Janfeshan, F. Masjedi, M. Rafiei and Z. Karimi,20211918Fan, X., W. Gu, Y. Gao, N. Ma, C. Fan and X. Ci,20212021Tomşa, A., A. Răchişan, S. Pandrea, A. Benea, A. Uifălean, A. Parvu and L. Junie,20212021Abdel-Fattah, M.M., A.N.A.M. Elgendy and W.R. Mohamed,20212021Babaeenezhad, E., N. Nouryazdan, M. Nasri, H. Ahmadvand and M.M. Sarabi,20212021Manikandan, R., M. Beulaja, R. Thiagarajan, A. Priyadarsini, R. Saravanan and M. Arumugam,2011670578585Randjelovic, P., S. Veljkovic, N. Stojiljkovic, L. Jankovic-Velickovic, D. Sokolovic, M. Stoiljkovic and I. Ilic,20122012El-Kashef, D.H., A.E. El-Kenawi, M.A. Rahim, G.M. Suddek and H.A. Salem,201694278286Okamoto, K., B.T. Eger, T. Nishino, S. Kondo, E.F. Pai and T. Nishino,200327818481855Faruque, L.I., A. Ehteshami-Afshar, N. Wiebe, L. Tjosvold, J. Homik and M. Tonelli,201343367375Liu, X., K. Liu, Q. Sun, Y. Wang, J. Meng, Z. Xu and Z. Shi,20181618591865Fahmi, A.N.A., G.S.G. Shehatou, A.M. Shebl and H.A. Salem,2016389269278Maresh, M.M., R.R. Abdelaziz and T.M. Ibrahim,2020via modulation of MCP-1, IL-1β, TNF-α, neutrophil infiltration, and apoptosis in mice.]]>2020Kimura, K., T. Hosoya, S. Uchida, M. Inaba and H. Makino et al.,201872798810Bardin, T. and P. Richette,201931152158Lee, J.W. and K.H. Lee,201951467473Kim, S., H.J. Kim, H.S. Ahn, S.W. Oh and K.H. Han et al.,201736274281Kwak, C.H., M. Sohn, N. Han, Y.S. Cho, Y.S. Kim and J.M. Oh,201856321327Chewcharat, A., Y. Chen, C. Thongprayoon, A.M. Harrison, M.A. Mao and W. Cheungpasitporn,202151752762Fahmi, A.N.A., G.S.G. Shehatou, A.M. Shebl and H.A. Salem,2016389819830Komers, R., B. Xu, J. Schneider and T.T. Oyama,201617325732588Khames, A., M.M. khalaf, A.M. Gad and O.M.A. El-Raouf,2017805118124Lee, H.J., K.H. Jeong, Y.G. Kim, J.Y. Moon and S.H. Lee et al.,2014405663Fukui, T., M. Maruyama, K. Yamauchi, S. Yoshitaka, T. Yasuda and Y. Abe,20153713961401Steubl, D. and M.C. Michel,2016389815817Alshahawey, M., S.M. Shaheen, T. Elsaid and N.A. Sabri,20195116491657Sircar, D., S. Chatterjee, R. Waikhom, V. Golay, A. Raychaudhury, S. Chatterjee and R. Pandey,201566945950Tanaka, K., M. Nakayama, M. Kanno, H. Kimura and K. Watanabe et al.,20151910441053Khaksari, M., S. Esmaili, R. Abedloo and H. Khastar,2021127273278Omori, H., N. Kawada, K. Inoue, Y. Ueda and R. Yamamoto et al.,201216549556Elsisi, A.E.E., S.S. Sokar, M.F. Shalaby and S.E.S. Abu-Risha,20211410391050Kent, A.L., L.E. Maxwell, M.E. Koina, M.C. Falk, D. Willenborg and J.E. Dahlstrom,200762307312Daina, A., O. Michielin and V. Zoete,20172017Yang, H., C. Lou, L. Sun, J. Li and Y. Cai et al.,20193510671069Lopez-Novoa, J.M., Y. Quiros, L. Vicente, A.I. Morales and F.J. Lopez-Hernandez,2011793345Bove, M., A.F.G. Cicero and C. Borghi,20172017Kielstein, J.T., R. Pontremoli and M. Burnier,20202020Frezzatti, R. and P.F. Silveira,2011Crotalus durissus terrificus snake venom: Comparison with probenecid.]]>2011Biagioni, E., M. Marietta, S. Busani, L. Rinaldi and M. Girardis,201240190192Hu, A.M. and J.N. Brown,20203932873294Yang, A.Y.,2020582128Malik, U.Z., N.J. Hundley, G. Romero, R. Radi, B.A. Freeman, M.M. Tarpey and E.E. Kelley,201151179184Sezai, A., M. Soma, K.I. Nakata, S. Osaka and Y. Ishii et al.,201566298303Omizo, H., Y. Tamura, C. Morimoto, M. Ueno and Y. Hayama et al.,20202020Lin, T.C., L.Y. Hung, Y.C. Chen, W.C. Lo, C.H. Lin, K.W. Tam and M.Y. Wu,20192019Tsuda, H., N. Kawada, J.Y. Kaimori, H. Kitamura and T. Moriyama et al.,2012427266272Edeogu, C.O., M.E. Kalu, A.C. Famurewa, N.T. Asogwa, G.N. Onyeji and K.O. Ikpemo,2020Moringa oleifera seed oil on gentamicin-induced nephrotoxicity in rats: Biochemical evaluation of antioxidant, anti-inflammatory, and antiapoptotic pathways.]]>39307315Sharma, V.C., A. Kaushik, Y.N. Dey, B. Srivastava, M. Wanjari, S. Pawar and S. Chougule,2021Anogeissus latifolia Roxb. (Dhava) against gentamicin-induced nephrotoxicity in rats.]]>2021Vega, M.W., S.J. Swartz, S. Devaraj and S. Poyyapakkam,20202020Gowda, S., P.B. Desai, S.S. Kulkarni, V.V. Hull, A.A.K. Math and S.N. Vernekar,20102170173Giordano, C., O. Karasik, K. King-Morris and A. Asmar,20152015Wu, H. and J. Huang,201819559567Cheng, F., W. Li, G. Liu and Y. Tang,2013In silico ADMET prediction: Recent advances, current challenges and future trends.]]>1312731289Lipinski, C.A., F. Lombardo, B.W. Dominy and P.J. Feeney,200146326