International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2022.869.876LiuWei LiJiehong WangJing SuYeqing LiYachai 52022185Background and Objective: Folic acid (FA) plays a vital part in pregnancy. This study analyzes the correlation of FA metabolism gene polymorphism with maternal delivery outcomes to provide reliable guidance for pregnant women. Materials and Methods: TaqMan-MGB was used to detect the C677T and A1298C loci of FA metabolism gene MTHFR and A66G locus of MTRR. The correlations of FA risk levels and metabolic gene polymorphism with adverse events (AEs) during pregnancy and final birth outcomes were discussed. Results: Significant differences were observed in the risk levels of FA disorders between normal pregnant women and those with oligohydramnios (OH), gestational diabetes mellitus (GDM) or gestational hypertension (GH), same results between pregnant women with the termination of pregnancy, premature birth, dystocia and congenital diseases in the newborn and those with normal delivery, the genotype of MTHFR C677T, MTHFR A1298C and MTRR A66G showed no difference, but the allele of MTHFR C677T differed evidently. Significant differences were also present in the risk levels of FA disorders. Conclusion: The risk levels of FA metabolism disorders are strongly related to AEs during pregnancy and adverse pregnancy outcomes.]]>van Gool, J.D., H. Hirche, H. Lax and L. de Schaepdrijver,2018807384Field, M.S. and P.J. Stover,201814145971Ferrazzi, E., G. Tiso and D.D. Martino,2020253312319Sijilmassi, O.,201925715731580Schisterman, E.F., L.A. Sjaarda, T. Clemons, D.T. Carrell and N.J. Perkins et al.,20203233548McNulty, H., M. Rollins, T. Cassidy, A. Caffrey and B. Marshall et al.,20192019Liu, H.Y., S.M. Liu and Y.Z. Zhang,202027963976Hiraoka, M. and Y. Kagawa,201757142149Wan, L., Y. Li, Z. Zhang, Z. Sun, Y. He and R. Li,20182018Vieira, D., C. Florindo, I.T. de Almeida and M.C. Macário,20202020Lean, S.C., H. Derricott, R.L. Jones and A.E.P. Heazell,20172017Frick, A.P.,20217092100Siekmans, K., M. Roche, J.K. Kungu, R.E. Desrochers and L.M. De-Regil,20172017Ziuo, F.Y.M., A. Alfituri, S. Elzwei and A.H.M. Senussi,2020747704777Levine, S.Z., A. Kodesh, A. Viktorin, L. Smith, R. Uher, A. Reichenberg and S. Sandin,2018Autism spectrum disorder in offspring.]]>75176184Wang, Y., Y. Jin, Y. Wang, L. Li, Y. Liao, Y. Zhang and D. Yu,20192019Servy, E.J., L. Jacquesson-Fournols, M. Cohen and Y.J.R. Menezo,20183514311435Valentin, M., P.C. Mazeau, M. Zerah, P.F. Ceccaldi, A. Benachi and D. Luton,2018799194Huang, W., X. Lu, J. Li and J. Zhang,20198110116Najafipour, R., S. Moghbelinejad, A. Aleyasin and A. Jalilvand,20175704710Clark, D.F., R. Schmelz, N. Rogers, N.E. Smith and K.R. Shorter,20212021Page, R., A. Wong, T.E. Arbuckle and A.J. MacFarlane,2019MTHFR 677c>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of canadian women.]]>110401409Qin, X., J.D. Spence, J. Li, Y. Zhang and Y. Li et al.,202012 and folate with MTHFR genotypes on risk of ischemic stroke.]]>94e1126e1136Bulloch, R.E., C.R. Wall, L.M.E. McCowan, R.S. Taylor, C.T. Roberts and J.M.D. Thompson,20202020Lin, Z., Q. Li, Y. Sun, J. Huang and W. Wang et al.,20192019Zhang, Y., X. He, X. Xiong, J. Chuan, L. Zhong, G. Chen and D. Yu,20193939