International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2022.1500.1508XianchuLiu 72022187Background and Objective: Diabetes is closely connected with abnormity of cognitive performance. Asiatic acid (AA) has various bioactivities and possesses preventive, protective and therapeutic functions in diabetic progression. However, no research has implied the prevention and treatment of AA on cognitive performance in diabetes. Materials and Methods: In this research, the diabetic rat model was established by STZ to appraise potentially therapeutic options of AA (30 mg/kg/day for 45 days) on diabetes-associated cognitive decline (DACD). After the last treatment, rats were euthanized to collect the hippocampus for mechanism research. Results: Current research demonstrated AA decreased escape latency and enhanced times of crossing platform to protect against diabetic-evoked cognitive dysfunctions. In the hippocampus, AA remarkably restricted AChE and GFAP expressions, while promoting ChAT, BDNF, Nrf-2 and HO-1 expressions. Moreover, AA remarkably augmented SOD, CAT and GSH contents and restrained MDA concentration to alleviate oxidative stress. Additionally, AA remarkably inhibited TNF-α and IL-1β productions to mitigate inflammatory response. Lastly, AA remarkably reduced Bax expression and increased Bcl-2 expression to relieve apoptosis. Conclusion: AA protected the hippocampus from diabetic-evoked cognitive dysfunctions through its bioactivities of anti-oxidation, anti-inflammation and anti-apoptosis and could be a powerful remedy approach in the ameliorations of DACD.]]>Moheet, A., S. Mangia and E.R. Seaquist,201513536071Wanrooy, B.J., K.P. Kumar, S.W. Wen, C.X. Qin, R.H. Ritchie and C.H.Y. Wong,20182018Yaribeygi, H., M. Ashrafizadeh, N.C. Henney, T. Sathyapalan, T. Jamialahmadi and A. Sahebkar,20202020Maresch, C.C., D.C. Stute, M.G. Alves, P.F. Oliveira, D.M. de Kretser and T. Linn,20182486105Zilliox, L.A., K. Chadrasekaran, J.Y. Kwan and J.W. Russell,20162016Ramachandran, V., R. Saravanan and P. Senthilraja,2014In vivo and in silico approaches.]]>21225232Hung, Y.C., H.T. Yang and M.C. Yin,2015via anti-glycative and anti-coagulatory activities in diabetic mice.]]>629672974Xu, M.F., Y.Y. Xiong, J.K. Liu, J.J. Qian, L. Zhu and J. Gao,2012Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells.]]>33578587Kaur, H., I. Patro, K. Tikoo and R. Sandhir,2015894050Xianchu, L., C. Changhao, D. Beiwang, P. Huan and L. Ming,202117370379Zhang, X.X., Y. Liu, S.S. Xu, R. Yang and C.H. Jiang et al.,2022Cyclocarya paliurus regulates the autophagy-lysosome system via directly inhibiting TGF-β type I receptor and ameliorates diabetic nephropathy fibrosis.]]>1355365546Wright, K.M., M. Bollen, J. David, A.B. Speers and M.S. Brandes et al.,2022Centella asiatica product in cognitively impaired older adults: A phase 1, double-blind, randomized clinical trial.]]>2022Kalidhindi, S., V.V.S. Uddandrao, V. Sasikumar, N. Raveendran and S. Ganapathy,2020183744Suryavanshi, J., C. Prakash and D. Sharma,20223717731785Lu, C.W., T.Y. Lin, T.L. Pan, P.W. Wang, K.M. Chiu, M.Y. Lee and S.J. Wang,20212021Loganathan, C. and P. Thayumanavan,201833151159Rakonczay, Z., Z. Horváth, A. Juhász and J. Kálmán,2005157-158233238Rather, M.A., A. Justin-Thenmozhi, T. Manivasagam, C. Saravanababu, G.J. Guillemin and M.M. Essa,201935955968ALmohaimeed, H.M., Z.M. Mohammedsaleh, A.H. Batawi, M.J. Balgoon and O.I. Ramadan et al.,2021Cinnamomum cassia and Zingiber officinale alleviate diabetes-induced hippocampal changes in male albino rats: Structural and molecular evidence.]]>2021Chao, P.C., M.C. Yin and M.C. Mong,2015D-galactose treated mice.]]>6542548Zhang, X., M. Ding, P. Zhu, H. Huang and Q. Zhuang et al.,20192019Jiang, W., M. Li, F. He, Z. Bian and Q. He et al.,20161574551Lee, J.W., H.A. Park, O.K. Kwon, Y.G. Jang and J.Y. Kim et al.,201639208217Qi, Z., X. Ci, J. Huang, Q. Liu, Q. Yu, J. Zhou and X. Deng,201788252259Rather, M.A., A.J. Thenmozhi, T. Manivasagam, M.D. Bharathi, M.M. Essa and G.J. Guillemin,201810262275Ha, J.S., J.Y. Kang, J.E. Kang, S.K. Park and J.M. Kim et al.,2020Actinidia arguta) improves brain dysfunction in high fat diet-induced obese mice.]]>2020Yan, S.L., Z.H. Wang, M.C. Mong, Y.C. Yang and M.C. Yin,2019126192198