International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2022.1126.1136Younis OmarTahani H. AbdelazizMennatallah Ahmed AbdelfattahMarwa Ahmed BahaaeldineManar Allah Abdelnabi Eid MohamedHeba Nasser MohammedEsraa Mohamed FathiWalaa Ramadan RashedAya Saber MohamedAyman FahmySohair R. Mohamed ElbatranMay 62022186Background and Objective: Earthworms are oligochaete soil macroinvertebrates that play an essential role in soil fertility and production throughout time. In the present study, an attempt has been made to assess the therapeutic effects of earthworm extract against myocardial infarction induced by epinephrine injection in rats. Materials and Methods: Myocardial infarction was induced in rats by injecting 2 mg kg1 epinephrine subcutaneously daily for 2 days. The rats were split into three groups: Control, MI and MI were given earthworm extract (60 mg kg1, orally) for 7 days. 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