International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2021.400.407Basheeruddin AsdaqSyed Mohammed Abdulaziz MannasahebBasheerahmed AlanaziAhmad AlmusharrafBader AlanaziNaif SaadKhalid AlanaziSami AbduallahKhalid AlrashidSaad AlanaziFaisal S. AlamriAbdulhakeem F. AlsanieWalaa AlhomraniMajid 62021176Background and Objective: Numerous natural bioactive compounds have demonstrated functional activity, implying that they could play a significant role in the treatment and management of a variety of chronic illnesses. Flavonoids, which include apigenin, make up the biggest group of naturally occurring polyphenols. Skeletal muscle relaxants are medications that relieve undesired spasms without impairing consciousness or reflexes. This study was done to evaluate the skeletal muscle relaxant property of Apigenin (APG) in experimental animal models. Materials and Methods: Three doses of apigenin (10, 25 and 25 mg kg1) were selected and their muscle relaxant activity was compared against standard diazepam 5 mg kg1 using climbing, chimney and modified Kondziela's inverted tests. The results obtained were analyzed using an analysis of variance (ANOVA) and a post-ANOVA Tukey multiple comparisons test. Results: Animals treated with 25 and 50 mg kg1 of APG exhibited significant difficulty in climbing up the chain, possibly due to relaxation of the muscles. Similarly, response time in the chimney test was significantly increased in those animals who received a high dose of APG (50 mg kg1) demonstrating the loss of alertness and retarded muscle tone resulting in difficulty with muscle coordination. Additionally, in inverted tests, animals treated with a high dose of APG had a significantly decreased duration of holding capacity on the mesh. A fall in muscle contraction leads to a decrease in holding time. Conclusion: Thus, our findings demonstrate that apigenin, when given orally to mice, has a dose-dependent skeletal muscle relaxant effect.]]>Naidu, S.V. and V. Rani,2019813811386Veena, N.S., K. Sivaji, G.V. Benerji, M.F. Babu and D.R. Kumari,20154714721George, M., L. Joseph and A. Sharma,2012Prosopis cineraria.]]>48577581Charles, R.C. and E.S. Robert,20036th Edn.,Pages: 832Pages: 832Chou, R., A. Qaseem, V. Snow, D. Casey, J.T. Cross, P. Shekelle and D.K. Owens,2007147478491van Tulder, M.W., T. Touray, A.D. Furlan, S. Solway and L.M. Bouter,20032819781992Münch, G., M. Venigalla and E. Gyengesi,20151011811185Salehi, B., A. Venditti, M. Sharifi-Rad, D. Kręgiel and J. Sharifi-Rad et al.,20192019Benavente-Garcia, O. and J. Castillo,20085661856205Hansen, E., M. Krautwald, A.E. Maczurek, G. Stuchbury and P. Fromm et al.,201019451464Myhrstad, M.C.W., H. Carlsen, O. Nordstrom, R. Blomhoff and J.O. Moskaug,200232386393Zheng, P.W., L.C. Chiang and C.C. Lin,20057613671379Shukla, S. and S. Gupta,20065843852Liu, X., L. Li, L. Lv, D. Chen, L. Shen and Z. Xie,20153410351041Nakazawa, T., T. Yasuda, J. Ueda and K. Ohsawa,200326474480Kopustinskiene, D.M., V. Jakstas, A. Savickas and J. Bernatoniene,20202020Sadraei, H., M. Ghanadian, G. Asghari and N. Sekhavati,20187100105Ali, F., Rahul, F. Naz, S. Jyoti and Y.H. Siddique,20172011971238Zhao, L., J.L. Wang, R. Liu, X.X. Li, J.F. Li and L. Zhang,20131899499965Adebesin, I.F., A.J. Akindele and O.O. Adeyemi,2015Albizia glaberrima (Leguminosae) in mice.]]>160101108El Shoubaky, G.A., M.M. Abdel-Daim, M.H. Mansour and E.A. Salem,2016102129Yemitan, O.K. and O.O. Adeyemi,2003Dalbergia saxatilis.]]>194246Ahmad, S.S., S. Priyambada and P. Vijayalakshmi,2019583944Adeyemi, O.O., O.K. Yemitan and A.E. Taiwo,2006Baphia nitida AFZEL.]]>106312316Vogel, H.G.,20022nd Edn.,Pages: 1408Pages: 1408Deacon, R.M.J.,20132013Bawazeer, S., A. Rauf and S. Bawazeer,2020Datura metel Linnaeus (Angel’s trumpet) fruits.]]>2020Luong, T.N., H.J. Carlisle, A. Southwell and P.H. Patterson,20112011Muhammad, N., M. Saeed, H. Khan and I. Haq,20132013García-Campos, P., X. Báez-Matus, C. Jara-Gutiérrez, M. Paz-Araos and C. Astorga et al.,20202020Kumar, S., R. Madaan and A. Sharma,200870847851Rotondo, A., R. Serio and F. Mulè,2009858590Losi, G., G. Puia, G. Garzon, M.C. de Vuono and M. Baraldi,20045024146Avallone, R., P. Zanoli, G. Puia, M. Kleinschnitz, P. Schreier and M. Baraldi,2000Matricaria chamomilla.]]>5913871394Huang, Y., X. Zhao, Y. Zu, L. Wang, Y. Deng, M. Wu and H. Wang,201918168182Alshehri, S.M., F. Shakeel, M.A. Ibrahim, E.M. Elzayat and M. Altamimi et al.,201927264273Durazzo, A., M. Lucarini, E. Camilli, S. Marconi and P. Gabrielli et al.,20182018