International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2021.130.137Nicotiana plumbaginifolia Linn against CCl4 Induced Oxidative Stress in Gallus gallusdomesticus]]>Saboor ShahAbdus AhmedMushtaq ul HaqNoor Ali KhanRahmat 32021173Background and Objective: Oxidative stress that may be the source of different disorders is caused by reactive oxygen species. CCl4 may cause oxidative stress. Antioxidant enzymes that are created by the body may scavenge the reactive oxygen species. The protective effects of Nicotiana plumbaginifolia (Linn) methanolic extract (NPME) against CCl4 induced oxidative damage in the kidneys and lungs of chicks were determined in this study. Materials and Methods: Two months old male Gallus gallusdomesticus chicks were subjected to this experiment. Total 36 chicks were divided into six groups i.e., Group I to VI were subjected under control, DMSO (1 mL kg1 b.wt.), 1 mL kg1 b.wt. CCl4 (50% in olive oil), silymarin (50 mg kg1 b.wt.) after 24 hrs of CCl4 administration, 100 and 200 mg kg1 b.wt. NPME after 24 hrs of CCl4 administration for three weeks. Results: The results revealed that CCl4 induced oxidative stress was more pronounced in the kidneys as compared to the lungs. CCl4 caused a significant decrease in the activity of kidney antioxidant enzymes (CAT, POD, GSH-Px) and glutathione (GSH), while an increase in the levels of TBARS, creatinine and urea than that of lungs samples. Conclusion: Since NPME treatment recovered towards normal conditions directly proportional to the dose applied and thus it was concluded that Nicotiana plumbaginifolia (Linn) methanolic extract can protect the kidneys more significantly than lungs tissues against CCl4 oxidative stress.]]>Covarrubias, L., D. Hernandez-Garcia, D. Schnabel, E. Salas-Vidal and S. Castro-Obregon,2008320111Gruber, J., S. Schaffer and B. Halliwell,20081365546579Tsai, J.C., C.S. Chiu, Y.C. Chen, M.S. Lee and X.Y. Hao et al.,2017Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice.]]>2017McGregor, D. and M. Lang,1996366181195Lee, T.Y., G.J. Wang, J.H. Chiu and H.C. Lin,2003Salvia miltiorrhiza ameliorates carbon tetrachloride-induced hepatic fibrosis in rats.]]>5515611568Khan, R.A., M.R. Khan and S. Sahreen,2010Launaea procumbens use in renal disorders: A rat model.]]>128452461Dogukan, A., N. Akpolat, H. Celiker, N. Ilhan, I.H. Bahcecioglu and A.I. Gunal,2003168184Adewole, S.O., A.A. Salako, O.W. Doherty and T. Naicker,200710153164Weber, L.W.D., M. Boll and A. Stampfl,200333105136Brautbar, N. and J. Williams,2002205479491Fruhwirth, G.O. and A. Hermetter,20082008pp: 351-367pp: 351-367Khan, M.R., W. Rizvi, G.N. Khan, R.A. Khan and S. Shaheen,2009Digera muricata.]]>1229199Rajesh, M.G. and M.S. Latha,2004Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage.]]>36284287Mizuguchi, S., S. Takemura, Y. Minamiyama, S. Kodai and T. Tsukioka et al.,20064-induced oxidative stress and pulmonary fibrosis in rats.]]>268192Zhang, H.Q., Y.F. Yau, K.Y. Szeto, W.T. Chan, J. Wong and M. Li,2007109543546Hwang, Y.P., C.Y. Choi, Y.C. Chung, S.S. Jeon and H.G. Jeong,20073013091317Fu, Y., S. Zheng, J. Lin, J. Ryerse and A. Chen,20084-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.]]>73399409Kuleci, S., I. Hanta, A. Kocabas and N. Canacankatan,200825710717Suzuki, S., S. Matsukura, H. Takeuchi, M. Kawaguchi and K. Ieki et al.,20081466772Sackesen, C., H. Ercan, E. Dizdar, O. Soyer and P. Gumus et al.,20081227885Niki, E.,2010in vitro and in vivo.]]>49503515Shah, A.S., M. Ahmed, H.M. Alkreathy, M.R. Khan, R.A. Khan and S. Khan,2014Trifolium alexandrinum (L.) against free radical-induced stress in rats.]]>2751757Lowry, O.H., N.J. Rosebrough, A.L. Farr and R.J. Randall,1951193265275Manna, P., M. Sinha and P.C. Sil,2006Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders.]]>2006Chance, B. and A.C. Maehly,19552764775Carlberg, I. and B. Mannervik,19751975Mohandas, J., J.J. Marshall, G.G. Duggin, J.S. Horvath and D.J. Tiller,19843318011807Habig, W.H., M.J. Pabst and W.B. Jakoby,197424971307139Wright, J.R., H.D. Colby and P.R. Miles,1981206296304Shah, A.S., R.A. Khan, M. Ahmed and N. Muhammad,2016Nicotiana plumbaginifolia Linn. against carbon tetrachloride-induced injuries.]]>32292298Khan, R.A., M.R. Khan and S. Sahreen,2012Sonchus asper extracts against experimentally induced lung injuries in rats: A novel study.]]>64725731Ajuwon, O.R. and O.M. Idowu,2010975257530Solcan, C., M. Gogu and G. Solcan,2011Hypophae rhamnoides oil against ochratoxicosis in chickens.]]>2011Lakshmi, D.U., K. Adilaxmamma, A.G. Reddy and V.V. Rao,2011Mangifera indica against lead-induced organ toxicity in broilers.]]>185861