International Journal of Pharmacology1811-77751812-5700Asian Network for Scientific Information10.3923/ijp.2019.759.765HaoYi WuBin LiChunguang 62019156Background and Objective: Heart attack or Myocardial infarct (MI) is one of the serious health issue as it claims many lives than any other heart disease. The present experiment was framed to explore the cardioprotective efficacy of naringenin (NG) against isoproterenol (ISO) induced heart failure (cardiotoxicity) in a rat model. Materials and Methods: A total of 32 male albino rats were procured and segregated into 4 groups as control-rats treated with saline (14 days), NG alone group- rats were treated orally with 50 mg kg1 of NG for 14 days, ISO induced-MI group-rats were injected intraperitoneally (i.p.) with ISO (85 mg kg1) for 2 days, NG+ISO induced group-rats orally treated with NG for 14 days followed by 2 days of ISO induction. Results: Rats pre-treated with NG for 14 days before ISO induction showed a significantly improvement in antioxidant status (Catalase, CAT, superoxide dismutase, SOD) and hemodynamic parameters (Systolic/diastolic arterial blood pressure). However, the levels of inflammatory markers (Nuclear factor kappa bp65 subunit, NF-κb p65 subunit, Tumor necrosis factor alpha, TNF-α, Interleukin 1 beta/six, IL-1β/6), cardiac markers (troponin C, cTn C, creatine kinase, CPK, lactate dehydrogenase, LDH), heart to body weight ratio and lipid peroxidation products (MDA) were considerably abolished upon NG supplemented rats as compared with ISO-induced rats. Moreover, the protein expression of NF-κb p65 subunit and IL-1β were substantially down regulated in rats that supplemented with NG. Conclusion: Taking together, that pretreatment with NG could significantly improve the antioxidant status and attenuate inflammatory response via down regulating NF-κb signaling pathway.]]>Xu, H., W. Li, J. Yang, S.D. Wiviott and M.S. Sabatine et al.,2016175193201Rossello, X., Y. Huo, S. Pocock, F. Van de Werf and C.T. Chin et al.,20172452734Kumar, M., E.R. Kasala, L.N. Bodduluru, V. Dahiya and M. Lahkar,201665613622Othman, A.I., M.M. Elkomy, M.A. El-Missiry and M. Dardor,20177942736Goyal, S.N., C. Sharma, U.B. Mahajan, C.R. Patil and Y.O. Agrawal et al.,2015162745727469Sagor, M., A. Taher, N. Tabassum, M. Potol and M. Alam,20152015Liu, Y.T., H.M. Jia, X. Chang, G. Ding, H.W. Zhang and Z.M. Zou,2013928232834Rajadurai, M. and P.S.M. Prince,2006228259268Karthick, M. and P.S.M. Prince,200658701707Heusch, G. and B.J. Gersh,201638774784Gu, M., A.B. Zheng, J. Jin, Y. Cui and N. Zhang et al.,20162016Jeon, S.M., H.K. Kim, H.J. Kim, G.M. Do, T.S. Jeong, Y.B. Park and M.S. Choi,20071491521Zaidun, N.H., Z.C. Thent and A.A. Latiff,2018208111122Rani, N., S. Bharti, B. Krishnamurthy, J. Bhatia and C. Sharma et al.,20162243414359Chtourou, Y., A.B. Slima, M. Makni, R. Gdoura and H. Fetoui,20156710901097Chtourou, Y., H. Fetoui, R. Jemai, A.B. Slima, M. Makni and R. Gdoura,201574696105Goyal, S.N., S. Arora, A.K. Sharma, S. Joshi and R. Ray et al.,2010Crocus sativus on hemodynamic, biochemical, histopathological and ultrastuctural alterations in isoproterenol-induced cardiotoxicity in rats.]]>17227232Zhang, N., Z. Yang, Y. Yuan, F. Li and Y. Liu et al.,20151022062212Tsutsui, H., T. Ide, S. Hayashidani, N. Suematsu and H. Utsumi et al.,200149103109Li, T.R., Z.Y. Yang and B.D. Wang,2007552628Lu, H., Y. Tan, L. Yang, H. Dong, Y. Liao, S. Cao and S. Fu,20181411451152Subburaman, S., K. Ganesan and M. Ramachandran,201433363376